Tune deafness: processing melodic errors outside of conscious awareness as reflected by components of the auditory ERP.

Tune deafness (TD) is a central auditory processing disorder characterized by the inability to discriminate pitch, reproduce melodies or to recognize deviations in melodic structure, in spite of normal hearing. The cause of the disorder is unknown. To identify a pathophysiological marker, we ascerta...

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Autores principales:	Allen Braun, Joe McArdle, Jennifer Jones, Vladimir Nechaev, Christopher Zalewski, Carmen Brewer, Dennis Drayna
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca2ecc8dbd92489f8d53a5d320c3a0c7
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spelling	oai:doaj.org-article:ca2ecc8dbd92489f8d53a5d320c3a0c72021-11-25T06:12:08ZTune deafness: processing melodic errors outside of conscious awareness as reflected by components of the auditory ERP.1932-620310.1371/journal.pone.0002349https://doaj.org/article/ca2ecc8dbd92489f8d53a5d320c3a0c72008-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18545651/?tool=EBIhttps://doaj.org/toc/1932-6203Tune deafness (TD) is a central auditory processing disorder characterized by the inability to discriminate pitch, reproduce melodies or to recognize deviations in melodic structure, in spite of normal hearing. The cause of the disorder is unknown. To identify a pathophysiological marker, we ascertained a group of severely affected TD patients using the Distorted Tunes Test, an ecologically valid task with a longstanding history, and used electrophysiological methods to characterize the brain's responses to correct and incorrect melodic sequences. As expected, we identified a neural correlate of patients' unawareness of melodic distortions: deviant notes modulated long-latency auditory evoked potentials and elicited a mismatch negativity in controls but not in affected subjects. However a robust P300 was elicited by deviant notes, suggesting that, as in blindsight, TD subjects process stimuli that they cannot consciously perceive. Given the high heritability of TD, these patients may make it possible to use genetic methods to study cellular and molecular mechanisms underlying conscious awareness.Allen BraunJoe McArdleJennifer JonesVladimir NechaevChristopher ZalewskiCarmen BrewerDennis DraynaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 6, p e2349 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Allen Braun Joe McArdle Jennifer Jones Vladimir Nechaev Christopher Zalewski Carmen Brewer Dennis Drayna Tune deafness: processing melodic errors outside of conscious awareness as reflected by components of the auditory ERP.
description	Tune deafness (TD) is a central auditory processing disorder characterized by the inability to discriminate pitch, reproduce melodies or to recognize deviations in melodic structure, in spite of normal hearing. The cause of the disorder is unknown. To identify a pathophysiological marker, we ascertained a group of severely affected TD patients using the Distorted Tunes Test, an ecologically valid task with a longstanding history, and used electrophysiological methods to characterize the brain's responses to correct and incorrect melodic sequences. As expected, we identified a neural correlate of patients' unawareness of melodic distortions: deviant notes modulated long-latency auditory evoked potentials and elicited a mismatch negativity in controls but not in affected subjects. However a robust P300 was elicited by deviant notes, suggesting that, as in blindsight, TD subjects process stimuli that they cannot consciously perceive. Given the high heritability of TD, these patients may make it possible to use genetic methods to study cellular and molecular mechanisms underlying conscious awareness.
format	article
author	Allen Braun Joe McArdle Jennifer Jones Vladimir Nechaev Christopher Zalewski Carmen Brewer Dennis Drayna
author_facet	Allen Braun Joe McArdle Jennifer Jones Vladimir Nechaev Christopher Zalewski Carmen Brewer Dennis Drayna
author_sort	Allen Braun
title	Tune deafness: processing melodic errors outside of conscious awareness as reflected by components of the auditory ERP.
title_short	Tune deafness: processing melodic errors outside of conscious awareness as reflected by components of the auditory ERP.
title_full	Tune deafness: processing melodic errors outside of conscious awareness as reflected by components of the auditory ERP.
title_fullStr	Tune deafness: processing melodic errors outside of conscious awareness as reflected by components of the auditory ERP.
title_full_unstemmed	Tune deafness: processing melodic errors outside of conscious awareness as reflected by components of the auditory ERP.
title_sort	tune deafness: processing melodic errors outside of conscious awareness as reflected by components of the auditory erp.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/ca2ecc8dbd92489f8d53a5d320c3a0c7
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Tune deafness: processing melodic errors outside of conscious awareness as reflected by components of the auditory ERP.

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