Endoscopic filter fluorometer for emission detection of Protoporphyrin IX and its direct precursors in PDT and PDD

Photodynamic therapy (PDT) is a potential option for treatment of cancer since it can be performed non- invasive for superficial cancers or minimal-invasive with low traumatization. But PDT is intrinsically inefficient due to the complex accumulation of the photosensitizing drug inside the tumor and...

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Autores principales:	Boese Axel, Wagner Alexander, Friebe Michael, Bernd Liehr Uwe, Wendler Jakob Johann
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	photodynamic therapy endoscopic systems ppix cp-iii urology bladder cancer Medicine R
Acceso en línea:	https://doaj.org/article/ca2ef085657d4c61bd75744e54440c3e
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spelling	oai:doaj.org-article:ca2ef085657d4c61bd75744e54440c3e2021-12-05T14:10:43ZEndoscopic filter fluorometer for emission detection of Protoporphyrin IX and its direct precursors in PDT and PDD2364-550410.1515/cdbme-2020-3150https://doaj.org/article/ca2ef085657d4c61bd75744e54440c3e2020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3150https://doaj.org/toc/2364-5504Photodynamic therapy (PDT) is a potential option for treatment of cancer since it can be performed non- invasive for superficial cancers or minimal-invasive with low traumatization. But PDT is intrinsically inefficient due to the complex accumulation of the photosensitizing drug inside the tumor and the processes of heme syntheses to create the needed cell killing components. To optimize the outcome of PDT and increase acceptance as viable option it is necessary to predict the optimal time for the start of the treatment based on measurable precursors. A former cell study proposed a new filter fluorometer in a complex and sensitive setup. In this work we now designed and tested a simplified system that can be used in combination with standard endoscopic imaging systems. This system will be used as base to prove viability of this approach for a future clinical study.Boese AxelWagner AlexanderFriebe MichaelBernd Liehr UweWendler Jakob JohannDe Gruyterarticlephotodynamic therapyendoscopic systemsppixcp-iiiurologybladder cancerMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 587-590 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	photodynamic therapy endoscopic systems ppix cp-iii urology bladder cancer Medicine R
spellingShingle	photodynamic therapy endoscopic systems ppix cp-iii urology bladder cancer Medicine R Boese Axel Wagner Alexander Friebe Michael Bernd Liehr Uwe Wendler Jakob Johann Endoscopic filter fluorometer for emission detection of Protoporphyrin IX and its direct precursors in PDT and PDD
description	Photodynamic therapy (PDT) is a potential option for treatment of cancer since it can be performed non- invasive for superficial cancers or minimal-invasive with low traumatization. But PDT is intrinsically inefficient due to the complex accumulation of the photosensitizing drug inside the tumor and the processes of heme syntheses to create the needed cell killing components. To optimize the outcome of PDT and increase acceptance as viable option it is necessary to predict the optimal time for the start of the treatment based on measurable precursors. A former cell study proposed a new filter fluorometer in a complex and sensitive setup. In this work we now designed and tested a simplified system that can be used in combination with standard endoscopic imaging systems. This system will be used as base to prove viability of this approach for a future clinical study.
format	article
author	Boese Axel Wagner Alexander Friebe Michael Bernd Liehr Uwe Wendler Jakob Johann
author_facet	Boese Axel Wagner Alexander Friebe Michael Bernd Liehr Uwe Wendler Jakob Johann
author_sort	Boese Axel
title	Endoscopic filter fluorometer for emission detection of Protoporphyrin IX and its direct precursors in PDT and PDD
title_short	Endoscopic filter fluorometer for emission detection of Protoporphyrin IX and its direct precursors in PDT and PDD
title_full	Endoscopic filter fluorometer for emission detection of Protoporphyrin IX and its direct precursors in PDT and PDD
title_fullStr	Endoscopic filter fluorometer for emission detection of Protoporphyrin IX and its direct precursors in PDT and PDD
title_full_unstemmed	Endoscopic filter fluorometer for emission detection of Protoporphyrin IX and its direct precursors in PDT and PDD
title_sort	endoscopic filter fluorometer for emission detection of protoporphyrin ix and its direct precursors in pdt and pdd
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/ca2ef085657d4c61bd75744e54440c3e
work_keys_str_mv	AT boeseaxel endoscopicfilterfluorometerforemissiondetectionofprotoporphyrinixanditsdirectprecursorsinpdtandpdd AT wagneralexander endoscopicfilterfluorometerforemissiondetectionofprotoporphyrinixanditsdirectprecursorsinpdtandpdd AT friebemichael endoscopicfilterfluorometerforemissiondetectionofprotoporphyrinixanditsdirectprecursorsinpdtandpdd AT berndliehruwe endoscopicfilterfluorometerforemissiondetectionofprotoporphyrinixanditsdirectprecursorsinpdtandpdd AT wendlerjakobjohann endoscopicfilterfluorometerforemissiondetectionofprotoporphyrinixanditsdirectprecursorsinpdtandpdd
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Endoscopic filter fluorometer for emission detection of Protoporphyrin IX and its direct precursors in PDT and PDD

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