Coxiella burnetii in humans and ticks in rural Senegal.

<h4>Background</h4>Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Epidemiologically, animals are considered reservoirs and humans incidental hosts.<h4>Methodology/principal findings</h4>We investigated Q fever in rural Senegal. Human samples (e.g., sera,...

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Autores principales:	Oleg Mediannikov, Florence Fenollar, Cristina Socolovschi, Georges Diatta, Hubert Bassene, Jean-François Molez, Cheikh Sokhna, Jean-François Trape, Didier Raoult
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/ca30843d136849cb9446395532fa0cb0
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spelling	oai:doaj.org-article:ca30843d136849cb9446395532fa0cb02021-11-25T06:33:36ZCoxiella burnetii in humans and ticks in rural Senegal.1935-27271935-273510.1371/journal.pntd.0000654https://doaj.org/article/ca30843d136849cb9446395532fa0cb02010-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20386603/pdf/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Epidemiologically, animals are considered reservoirs and humans incidental hosts.<h4>Methodology/principal findings</h4>We investigated Q fever in rural Senegal. Human samples (e.g., sera, saliva, breast milk, feces) were screened in the generally healthy population of two villages of the Sine-Saloum region. Ticks were collected in four regions. Seroprevalence was studied by immunofluorescence, and all other samples were tested by two qPCR systems for detection of C. burnetii. Positive samples were genotyped (multispacer typing) by amplification and sequencing of three spacers. Strains were isolated by cell culture. We found that the seroprevalence may be as high as 24.5% (59 of 238 studied) in Dielmo village. We identified spontaneous excretion of C. burnetii by humans through faeces and milk. Hard and soft ticks (8 species) were infected in 0-37.6%. We identified three genotypes of C. burnetii. The previously identified genotype 6 was the most common in ticks in all studied regions and the only one found in human samples. Three strains of genotype 6 of C. burnetii were also recovered from soft tick Ornithodoros sonrai. Two other genotypes found in ticks, 35 and 36, were identified for the first time.<h4>Conclusions/significance</h4>Q fever should be considered a significant public health threat in Senegal. Humans, similar to other mammals, may continuously excrete C. burnetii.Oleg MediannikovFlorence FenollarCristina SocolovschiGeorges DiattaHubert BasseneJean-François MolezCheikh SokhnaJean-François TrapeDidier RaoultPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 4, Iss 4, p e654 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Oleg Mediannikov Florence Fenollar Cristina Socolovschi Georges Diatta Hubert Bassene Jean-François Molez Cheikh Sokhna Jean-François Trape Didier Raoult Coxiella burnetii in humans and ticks in rural Senegal.
description	<h4>Background</h4>Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Epidemiologically, animals are considered reservoirs and humans incidental hosts.<h4>Methodology/principal findings</h4>We investigated Q fever in rural Senegal. Human samples (e.g., sera, saliva, breast milk, feces) were screened in the generally healthy population of two villages of the Sine-Saloum region. Ticks were collected in four regions. Seroprevalence was studied by immunofluorescence, and all other samples were tested by two qPCR systems for detection of C. burnetii. Positive samples were genotyped (multispacer typing) by amplification and sequencing of three spacers. Strains were isolated by cell culture. We found that the seroprevalence may be as high as 24.5% (59 of 238 studied) in Dielmo village. We identified spontaneous excretion of C. burnetii by humans through faeces and milk. Hard and soft ticks (8 species) were infected in 0-37.6%. We identified three genotypes of C. burnetii. The previously identified genotype 6 was the most common in ticks in all studied regions and the only one found in human samples. Three strains of genotype 6 of C. burnetii were also recovered from soft tick Ornithodoros sonrai. Two other genotypes found in ticks, 35 and 36, were identified for the first time.<h4>Conclusions/significance</h4>Q fever should be considered a significant public health threat in Senegal. Humans, similar to other mammals, may continuously excrete C. burnetii.
format	article
author	Oleg Mediannikov Florence Fenollar Cristina Socolovschi Georges Diatta Hubert Bassene Jean-François Molez Cheikh Sokhna Jean-François Trape Didier Raoult
author_facet	Oleg Mediannikov Florence Fenollar Cristina Socolovschi Georges Diatta Hubert Bassene Jean-François Molez Cheikh Sokhna Jean-François Trape Didier Raoult
author_sort	Oleg Mediannikov
title	Coxiella burnetii in humans and ticks in rural Senegal.
title_short	Coxiella burnetii in humans and ticks in rural Senegal.
title_full	Coxiella burnetii in humans and ticks in rural Senegal.
title_fullStr	Coxiella burnetii in humans and ticks in rural Senegal.
title_full_unstemmed	Coxiella burnetii in humans and ticks in rural Senegal.
title_sort	coxiella burnetii in humans and ticks in rural senegal.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/ca30843d136849cb9446395532fa0cb0
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Coxiella burnetii in humans and ticks in rural Senegal.

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