Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification

Neural stem and progenitor cells (NSPCs) encounter constant stresses during aging, such as elevated oxidative stress. Here the authors show that oxidative stress induced reduction in NSPC neural differentiation is mediated by a FOXO3-GNMT/SAM-lamin-cGAS/STING-IFN-I signalling cascade initiated by FO...

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Autores principales:	Inah Hwang, Hiroki Uchida, Ziwei Dai, Fei Li, Teresa Sanchez, Jason W. Locasale, Lewis C. Cantley, Hongwu Zheng, Jihye Paik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ca30ad5f34a0473993a7b4f89ef269d0
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spelling	oai:doaj.org-article:ca30ad5f34a0473993a7b4f89ef269d02021-12-02T14:16:14ZCellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification10.1038/s41467-020-20839-02041-1723https://doaj.org/article/ca30ad5f34a0473993a7b4f89ef269d02021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20839-0https://doaj.org/toc/2041-1723Neural stem and progenitor cells (NSPCs) encounter constant stresses during aging, such as elevated oxidative stress. Here the authors show that oxidative stress induced reduction in NSPC neural differentiation is mediated by a FOXO3-GNMT/SAM-lamin-cGAS/STING-IFN-I signalling cascade initiated by FOXO3 oxidation.Inah HwangHiroki UchidaZiwei DaiFei LiTeresa SanchezJason W. LocasaleLewis C. CantleyHongwu ZhengJihye PaikNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Inah Hwang Hiroki Uchida Ziwei Dai Fei Li Teresa Sanchez Jason W. Locasale Lewis C. Cantley Hongwu Zheng Jihye Paik Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification
description	Neural stem and progenitor cells (NSPCs) encounter constant stresses during aging, such as elevated oxidative stress. Here the authors show that oxidative stress induced reduction in NSPC neural differentiation is mediated by a FOXO3-GNMT/SAM-lamin-cGAS/STING-IFN-I signalling cascade initiated by FOXO3 oxidation.
format	article
author	Inah Hwang Hiroki Uchida Ziwei Dai Fei Li Teresa Sanchez Jason W. Locasale Lewis C. Cantley Hongwu Zheng Jihye Paik
author_facet	Inah Hwang Hiroki Uchida Ziwei Dai Fei Li Teresa Sanchez Jason W. Locasale Lewis C. Cantley Hongwu Zheng Jihye Paik
author_sort	Inah Hwang
title	Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification
title_short	Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification
title_full	Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification
title_fullStr	Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification
title_full_unstemmed	Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification
title_sort	cellular stress signaling activates type-i ifn response through foxo3-regulated lamin posttranslational modification
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ca30ad5f34a0473993a7b4f89ef269d0
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Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification

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