Prognostic Value of Ventricular‐Arterial Coupling After Transcatheter Aortic Valve Replacement on Midterm Clinical Outcomes
Background Ventricular‐arterial coupling predicts outcomes in patients with heart failure. The arterial elastance to end‐systolic elastance ratio (Ea/Ees) is a noninvasively assessed index that reflects ventricular‐arterial coupling. We aimed to determine the prognostic value of ventricular‐arterial...
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2021
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oai:doaj.org-article:ca30b06d557f4681b1d5f50d74ef95fe2021-11-23T11:36:34ZPrognostic Value of Ventricular‐Arterial Coupling After Transcatheter Aortic Valve Replacement on Midterm Clinical Outcomes10.1161/JAHA.120.0192672047-9980https://doaj.org/article/ca30b06d557f4681b1d5f50d74ef95fe2021-09-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.120.019267https://doaj.org/toc/2047-9980Background Ventricular‐arterial coupling predicts outcomes in patients with heart failure. The arterial elastance to end‐systolic elastance ratio (Ea/Ees) is a noninvasively assessed index that reflects ventricular‐arterial coupling. We aimed to determine the prognostic value of ventricular‐arterial coupling assessed through Ea/Ees after transcatheter aortic valve replacement to predict clinical events. Methods and Results We retrieved data on 1378 patients (70% women) who underwent transcatheter aortic valve replacement between October 2013 and May 2017 from the OCEAN‐TAVI (Optimized transCathEter vAlvular iNtervention) Japanese multicenter registry. We determined the association between Ea/Ees and the composite end point of hospitalization for heart failure and cardiovascular death by classifying the patients into quartiles based on Ea/Ees values (group 1: <0.326; group 2: 0.326–0.453; group 3: 0.453–0.666; and group 4: >0.666) during the midterm follow‐up after transcatheter aortic valve replacement. During a median follow‐up period of 736 days (interquartile range, 414–956), there were 247 (17.9%) all‐cause deaths, 89 (6.5%) cardiovascular deaths, 130 (9.4%) hospitalizations for heart failure, and 199 (14.4%) composite events of hospitalization for heart failure and cardiovascular death. The incidence of the composite end point was significantly higher in group 2 (hazard ratio [HR], 1.76; 95% CI, 1.08–2.87 [P=0.024]), group 3 (HR, 2.43; 95% CI, 1.53–3.86 [P<0.001]), and group 4 (HR, 2.89; 95% CI, 1.83–4.57 [P<0.001]) than that in group 1. On adjusted multivariable Cox analysis, Ea/Ees was significantly associated with composite events (HR, 1.47 per 1‐unit increase; 95% CI, 1.08–2.01 [P=0.015]). Conclusions These findings suggest that a higher Ea/Ees at discharge after transcatheter aortic valve replacement is associated with adverse clinical outcomes during midterm follow‐up. Registration URL: https://www.upload.umin.ac.jp/. Unique identifier: UMIN000020423.Hiroaki YokoyamaFutoshi YamanakaKoki ShishidoTomoki OchiaiShohei YokotaNoriaki MoriyamaYusuke WatanabeShinichi ShiraiNorio TadaMotoharu ArakiFumiaki YashimaToru NaganumaHiroshi UenoMinoru TabataKazuki MizutaniKensuke TakagiMasanori YamamotoShigeru SaitoKentaro HayashidaWileyarticleheart failuretranscatheter aortic valve replacementventricular‐aortic couplingDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 18 (2021) |
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EN |
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heart failure transcatheter aortic valve replacement ventricular‐aortic coupling Diseases of the circulatory (Cardiovascular) system RC666-701 |
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heart failure transcatheter aortic valve replacement ventricular‐aortic coupling Diseases of the circulatory (Cardiovascular) system RC666-701 Hiroaki Yokoyama Futoshi Yamanaka Koki Shishido Tomoki Ochiai Shohei Yokota Noriaki Moriyama Yusuke Watanabe Shinichi Shirai Norio Tada Motoharu Araki Fumiaki Yashima Toru Naganuma Hiroshi Ueno Minoru Tabata Kazuki Mizutani Kensuke Takagi Masanori Yamamoto Shigeru Saito Kentaro Hayashida Prognostic Value of Ventricular‐Arterial Coupling After Transcatheter Aortic Valve Replacement on Midterm Clinical Outcomes |
| description |
Background Ventricular‐arterial coupling predicts outcomes in patients with heart failure. The arterial elastance to end‐systolic elastance ratio (Ea/Ees) is a noninvasively assessed index that reflects ventricular‐arterial coupling. We aimed to determine the prognostic value of ventricular‐arterial coupling assessed through Ea/Ees after transcatheter aortic valve replacement to predict clinical events. Methods and Results We retrieved data on 1378 patients (70% women) who underwent transcatheter aortic valve replacement between October 2013 and May 2017 from the OCEAN‐TAVI (Optimized transCathEter vAlvular iNtervention) Japanese multicenter registry. We determined the association between Ea/Ees and the composite end point of hospitalization for heart failure and cardiovascular death by classifying the patients into quartiles based on Ea/Ees values (group 1: <0.326; group 2: 0.326–0.453; group 3: 0.453–0.666; and group 4: >0.666) during the midterm follow‐up after transcatheter aortic valve replacement. During a median follow‐up period of 736 days (interquartile range, 414–956), there were 247 (17.9%) all‐cause deaths, 89 (6.5%) cardiovascular deaths, 130 (9.4%) hospitalizations for heart failure, and 199 (14.4%) composite events of hospitalization for heart failure and cardiovascular death. The incidence of the composite end point was significantly higher in group 2 (hazard ratio [HR], 1.76; 95% CI, 1.08–2.87 [P=0.024]), group 3 (HR, 2.43; 95% CI, 1.53–3.86 [P<0.001]), and group 4 (HR, 2.89; 95% CI, 1.83–4.57 [P<0.001]) than that in group 1. On adjusted multivariable Cox analysis, Ea/Ees was significantly associated with composite events (HR, 1.47 per 1‐unit increase; 95% CI, 1.08–2.01 [P=0.015]). Conclusions These findings suggest that a higher Ea/Ees at discharge after transcatheter aortic valve replacement is associated with adverse clinical outcomes during midterm follow‐up. Registration URL: https://www.upload.umin.ac.jp/. Unique identifier: UMIN000020423. |
| format |
article |
| author |
Hiroaki Yokoyama Futoshi Yamanaka Koki Shishido Tomoki Ochiai Shohei Yokota Noriaki Moriyama Yusuke Watanabe Shinichi Shirai Norio Tada Motoharu Araki Fumiaki Yashima Toru Naganuma Hiroshi Ueno Minoru Tabata Kazuki Mizutani Kensuke Takagi Masanori Yamamoto Shigeru Saito Kentaro Hayashida |
| author_facet |
Hiroaki Yokoyama Futoshi Yamanaka Koki Shishido Tomoki Ochiai Shohei Yokota Noriaki Moriyama Yusuke Watanabe Shinichi Shirai Norio Tada Motoharu Araki Fumiaki Yashima Toru Naganuma Hiroshi Ueno Minoru Tabata Kazuki Mizutani Kensuke Takagi Masanori Yamamoto Shigeru Saito Kentaro Hayashida |
| author_sort |
Hiroaki Yokoyama |
| title |
Prognostic Value of Ventricular‐Arterial Coupling After Transcatheter Aortic Valve Replacement on Midterm Clinical Outcomes |
| title_short |
Prognostic Value of Ventricular‐Arterial Coupling After Transcatheter Aortic Valve Replacement on Midterm Clinical Outcomes |
| title_full |
Prognostic Value of Ventricular‐Arterial Coupling After Transcatheter Aortic Valve Replacement on Midterm Clinical Outcomes |
| title_fullStr |
Prognostic Value of Ventricular‐Arterial Coupling After Transcatheter Aortic Valve Replacement on Midterm Clinical Outcomes |
| title_full_unstemmed |
Prognostic Value of Ventricular‐Arterial Coupling After Transcatheter Aortic Valve Replacement on Midterm Clinical Outcomes |
| title_sort |
prognostic value of ventricular‐arterial coupling after transcatheter aortic valve replacement on midterm clinical outcomes |
| publisher |
Wiley |
| publishDate |
2021 |
| url |
https://doaj.org/article/ca30b06d557f4681b1d5f50d74ef95fe |
| work_keys_str_mv |
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1718416791826333696 |