PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland

The origin and source of mammary gland progenitors and how they interact with the adipose‐rich stroma is unclear. Here, the authors identify PDGFRα+ adipocyte progenitors in the murine mammary stroma as a mesenchymal cell lineage recruited into the expanding epithelium during development, hormone ex...

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Autores principales:	Purna A. Joshi, Paul D. Waterhouse, Katayoon Kasaian, Hui Fang, Olga Gulyaeva, Hei Sook Sul, Paul C. Boutros, Rama Khokha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ca3212bb13c842369939f7f12391cab1
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spelling	oai:doaj.org-article:ca3212bb13c842369939f7f12391cab12021-12-02T17:32:55ZPDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland10.1038/s41467-019-09748-z2041-1723https://doaj.org/article/ca3212bb13c842369939f7f12391cab12019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09748-zhttps://doaj.org/toc/2041-1723The origin and source of mammary gland progenitors and how they interact with the adipose‐rich stroma is unclear. Here, the authors identify PDGFRα+ adipocyte progenitors in the murine mammary stroma as a mesenchymal cell lineage recruited into the expanding epithelium during development, hormone exposure and pregnancy.Purna A. JoshiPaul D. WaterhouseKatayoon KasaianHui FangOlga GulyaevaHei Sook SulPaul C. BoutrosRama KhokhaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Purna A. Joshi Paul D. Waterhouse Katayoon Kasaian Hui Fang Olga Gulyaeva Hei Sook Sul Paul C. Boutros Rama Khokha PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland
description	The origin and source of mammary gland progenitors and how they interact with the adipose‐rich stroma is unclear. Here, the authors identify PDGFRα+ adipocyte progenitors in the murine mammary stroma as a mesenchymal cell lineage recruited into the expanding epithelium during development, hormone exposure and pregnancy.
format	article
author	Purna A. Joshi Paul D. Waterhouse Katayoon Kasaian Hui Fang Olga Gulyaeva Hei Sook Sul Paul C. Boutros Rama Khokha
author_facet	Purna A. Joshi Paul D. Waterhouse Katayoon Kasaian Hui Fang Olga Gulyaeva Hei Sook Sul Paul C. Boutros Rama Khokha
author_sort	Purna A. Joshi
title	PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland
title_short	PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland
title_full	PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland
title_fullStr	PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland
title_full_unstemmed	PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland
title_sort	pdgfrα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ca3212bb13c842369939f7f12391cab1
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PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland

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