Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation

Interleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1 (IL-22R1) and the IL-10 receptor 2 (IL-10R2). As the IL-22R1/IL-10R2 heterodimer is preferentially expressed on border tissue betw...

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Autores principales:	Masutaka Furue, Mihoko Furue
Formato:	article
Lenguaje:	EN
Publicado:	Open Exploration Publishing Inc. 2021
Materias:	il-22 il-22 receptor aryl hydrocarbon receptor skin barrier keratinocyte atopic dermatitis psoriasis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ca334c05404a437f849d4dd89af3cb9a
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spelling	oai:doaj.org-article:ca334c05404a437f849d4dd89af3cb9a2021-11-24T01:43:11ZInterleukin-22 and keratinocytes; pathogenic implications in skin inflammation10.37349/ei.2021.000052768-6655https://doaj.org/article/ca334c05404a437f849d4dd89af3cb9a2021-04-01T00:00:00Zhttps://www.explorationpub.com/Journals/ei/Article/10035https://doaj.org/toc/2768-6655Interleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1 (IL-22R1) and the IL-10 receptor 2 (IL-10R2). As the IL-22R1/IL-10R2 heterodimer is preferentially expressed on border tissue between the host and the environment, IL-22 is believed to be involved in border defense. Epidermal keratinocytes are the first-line skin barrier and express IL-22R1/IL-10R2. IL-22 increases keratinocyte proliferation but inhibits differentiation. Aryl hydrocarbon receptor (AHR) is a chemical sensor and an essential transcription factor for IL-22 production. In addition, AHR also upregulates the production of barrier-related proteins such as filaggrin in keratinocytes, suggesting a pivotal role for the AHR-IL-22 axis in regulating the physiological skin barrier. Although IL-22 signatures are elevated in atopic dermatitis and psoriasis, their pathogenic and/or protective implications are not fully understood.Masutaka FurueMihoko FurueOpen Exploration Publishing Inc.articleil-22il-22 receptoraryl hydrocarbon receptorskin barrierkeratinocyteatopic dermatitispsoriasisImmunologic diseases. AllergyRC581-607ENExploration of Immunology, Vol 1, Iss 1, Pp 37-47 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	il-22 il-22 receptor aryl hydrocarbon receptor skin barrier keratinocyte atopic dermatitis psoriasis Immunologic diseases. Allergy RC581-607
spellingShingle	il-22 il-22 receptor aryl hydrocarbon receptor skin barrier keratinocyte atopic dermatitis psoriasis Immunologic diseases. Allergy RC581-607 Masutaka Furue Mihoko Furue Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
description	Interleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1 (IL-22R1) and the IL-10 receptor 2 (IL-10R2). As the IL-22R1/IL-10R2 heterodimer is preferentially expressed on border tissue between the host and the environment, IL-22 is believed to be involved in border defense. Epidermal keratinocytes are the first-line skin barrier and express IL-22R1/IL-10R2. IL-22 increases keratinocyte proliferation but inhibits differentiation. Aryl hydrocarbon receptor (AHR) is a chemical sensor and an essential transcription factor for IL-22 production. In addition, AHR also upregulates the production of barrier-related proteins such as filaggrin in keratinocytes, suggesting a pivotal role for the AHR-IL-22 axis in regulating the physiological skin barrier. Although IL-22 signatures are elevated in atopic dermatitis and psoriasis, their pathogenic and/or protective implications are not fully understood.
format	article
author	Masutaka Furue Mihoko Furue
author_facet	Masutaka Furue Mihoko Furue
author_sort	Masutaka Furue
title	Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
title_short	Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
title_full	Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
title_fullStr	Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
title_full_unstemmed	Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
title_sort	interleukin-22 and keratinocytes; pathogenic implications in skin inflammation
publisher	Open Exploration Publishing Inc.
publishDate	2021
url	https://doaj.org/article/ca334c05404a437f849d4dd89af3cb9a
work_keys_str_mv	AT masutakafurue interleukin22andkeratinocytespathogenicimplicationsinskininflammation AT mihokofurue interleukin22andkeratinocytespathogenicimplicationsinskininflammation
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Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation

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