Host- and Strain-Specific Regulation of Influenza Virus Polymerase Activity by Interacting Cellular Proteins

ABSTRACT Highly pathogenic avian influenza A (HPAI) viruses of the H5N1 subtype have recently emerged from avian zoonotic reservoirs to cause fatal human disease. Adaptation of HPAI virus RNA-dependent RNA polymerase (PB1, PB2, and PA proteins) and nucleoprotein (NP) to interactions with mammalian h...

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Autores principales: Eric Bortz, Liset Westera, Jad Maamary, John Steel, Randy A. Albrecht, Balaji Manicassamy, Geoffrey Chase, Luis Martínez-Sobrido, Martin Schwemmle, Adolfo García-Sastre
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2011
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Acceso en línea:https://doaj.org/article/ca34bbf134f14f6dabe7f0d60ab0c2a6
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