A Review on P300 in Obsessive-Compulsive Disorder

Neuropsychological studies indicate the presence of cognitive changes in patients with obsessive-compulsive disorder (OCD). Indeed, OCD may be included among the dysfunctions of the frontal lobes and their connections with the limbic system, associative cortex, and basal ganglia. P300 is a positive...

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Autores principales:	Alberto Raggi, Giuseppe Lanza, Raffaele Ferri
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cortical hyperarousal information processing obsessive-compulsive disorder over-focused attention p300 translational neuroscience Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/ca369aabbc8449adac5c215eb24f23a0
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spelling	oai:doaj.org-article:ca369aabbc8449adac5c215eb24f23a02021-11-30T11:59:05ZA Review on P300 in Obsessive-Compulsive Disorder1664-064010.3389/fpsyt.2021.751215https://doaj.org/article/ca369aabbc8449adac5c215eb24f23a02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.751215/fullhttps://doaj.org/toc/1664-0640Neuropsychological studies indicate the presence of cognitive changes in patients with obsessive-compulsive disorder (OCD). Indeed, OCD may be included among the dysfunctions of the frontal lobes and their connections with the limbic system, associative cortex, and basal ganglia. P300 is a positive component of the human event-related potential (ERP); it is associated with processes of encoding, identification, and categorization constituting, as a whole, the superior cortical function of information processing. Thus, P300 explores several areas that are implicated in OCD pathophysiology. Our aim is to review all relevant studies on the P300 component of the human ERP in order to recognize any significant central nervous system (CNS) correlate of cognitive dysfunction in OCD. A PubMed-based literature search resulted in 35 articles assessing P300 in OCD and reporting neurophysiological correlates of response inhibition, cortical hyperarousal, and over-focused attention. A decreased P300 amplitude was reported in both adult and pediatric patients, with a trend toward normalization after pharmacological treatment. Source localization studies disclosed an association between P300 abnormalities and the functioning of brain regions involved in the pathophysiology of OCD. Moreover, studies converge on the evidence of neurophysiological dysfunction in the frontal areas with impairment of the normal inhibitory processes in OCD. At least some of these electrophysiological correlates might reflect the obsessive thoughts and compulsions that characterize this disorder. These findings may also support cognitive-behavioral therapy (CBT) approaches on over-focused attention and inflexibility of compulsive behaviors, which should be associated to pharmacological treatment in these patients.Alberto RaggiGiuseppe LanzaGiuseppe LanzaRaffaele FerriFrontiers Media S.A.articlecortical hyperarousalinformation processingobsessive-compulsive disorderover-focused attentionp300translational neurosciencePsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cortical hyperarousal information processing obsessive-compulsive disorder over-focused attention p300 translational neuroscience Psychiatry RC435-571
spellingShingle	cortical hyperarousal information processing obsessive-compulsive disorder over-focused attention p300 translational neuroscience Psychiatry RC435-571 Alberto Raggi Giuseppe Lanza Giuseppe Lanza Raffaele Ferri A Review on P300 in Obsessive-Compulsive Disorder
description	Neuropsychological studies indicate the presence of cognitive changes in patients with obsessive-compulsive disorder (OCD). Indeed, OCD may be included among the dysfunctions of the frontal lobes and their connections with the limbic system, associative cortex, and basal ganglia. P300 is a positive component of the human event-related potential (ERP); it is associated with processes of encoding, identification, and categorization constituting, as a whole, the superior cortical function of information processing. Thus, P300 explores several areas that are implicated in OCD pathophysiology. Our aim is to review all relevant studies on the P300 component of the human ERP in order to recognize any significant central nervous system (CNS) correlate of cognitive dysfunction in OCD. A PubMed-based literature search resulted in 35 articles assessing P300 in OCD and reporting neurophysiological correlates of response inhibition, cortical hyperarousal, and over-focused attention. A decreased P300 amplitude was reported in both adult and pediatric patients, with a trend toward normalization after pharmacological treatment. Source localization studies disclosed an association between P300 abnormalities and the functioning of brain regions involved in the pathophysiology of OCD. Moreover, studies converge on the evidence of neurophysiological dysfunction in the frontal areas with impairment of the normal inhibitory processes in OCD. At least some of these electrophysiological correlates might reflect the obsessive thoughts and compulsions that characterize this disorder. These findings may also support cognitive-behavioral therapy (CBT) approaches on over-focused attention and inflexibility of compulsive behaviors, which should be associated to pharmacological treatment in these patients.
format	article
author	Alberto Raggi Giuseppe Lanza Giuseppe Lanza Raffaele Ferri
author_facet	Alberto Raggi Giuseppe Lanza Giuseppe Lanza Raffaele Ferri
author_sort	Alberto Raggi
title	A Review on P300 in Obsessive-Compulsive Disorder
title_short	A Review on P300 in Obsessive-Compulsive Disorder
title_full	A Review on P300 in Obsessive-Compulsive Disorder
title_fullStr	A Review on P300 in Obsessive-Compulsive Disorder
title_full_unstemmed	A Review on P300 in Obsessive-Compulsive Disorder
title_sort	review on p300 in obsessive-compulsive disorder
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ca369aabbc8449adac5c215eb24f23a0
work_keys_str_mv	AT albertoraggi areviewonp300inobsessivecompulsivedisorder AT giuseppelanza areviewonp300inobsessivecompulsivedisorder AT giuseppelanza areviewonp300inobsessivecompulsivedisorder AT raffaeleferri areviewonp300inobsessivecompulsivedisorder AT albertoraggi reviewonp300inobsessivecompulsivedisorder AT giuseppelanza reviewonp300inobsessivecompulsivedisorder AT giuseppelanza reviewonp300inobsessivecompulsivedisorder AT raffaeleferri reviewonp300inobsessivecompulsivedisorder
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A Review on P300 in Obsessive-Compulsive Disorder

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