Mitochondrial Metabolism in Melanoma

Melanoma and its associated alterations in cellular pathways have been growing areas of interest in research, especially as specific biological pathways are being elucidated. Some of these alterations include changes in the mitochondrial metabolism in melanoma. Many mitochondrial metabolic changes l...

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Autores principales:	Christina Huang, Rakan H. Radi, Jack L. Arbiser
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	melanoma mitochondria SOX2 SIRT3 MCL1 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ca3f080f46114f289e311f38e48f9e2f
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spelling	oai:doaj.org-article:ca3f080f46114f289e311f38e48f9e2f2021-11-25T17:12:45ZMitochondrial Metabolism in Melanoma10.3390/cells101131972073-4409https://doaj.org/article/ca3f080f46114f289e311f38e48f9e2f2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3197https://doaj.org/toc/2073-4409Melanoma and its associated alterations in cellular pathways have been growing areas of interest in research, especially as specific biological pathways are being elucidated. Some of these alterations include changes in the mitochondrial metabolism in melanoma. Many mitochondrial metabolic changes lead to differences in the survivability of cancer cells and confer resistance to targeted therapies. While extensive work has gone into characterizing mechanisms of resistance, the role of mitochondrial adaptation as a mode of resistance is not completely understood. In this review, we wish to explore mitochondrial metabolism in melanoma and how it impacts modes of resistance. There are several genes that play a major role in melanoma mitochondrial metabolism which require a full understanding to optimally target melanoma. These include BRAF, CRAF, SOX2, MCL1, TRAP1, RHOA, SRF, SIRT3, PTEN, and AKT1. We will be discussing the role of these genes in melanoma in greater detail. An enhanced understanding of mitochondrial metabolism and these modes of resistance may result in novel combinatorial and sequential therapies that may lead to greater therapeutic benefit.Christina HuangRakan H. RadiJack L. ArbiserMDPI AGarticlemelanomamitochondriaSOX2SIRT3MCL1Biology (General)QH301-705.5ENCells, Vol 10, Iss 3197, p 3197 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	melanoma mitochondria SOX2 SIRT3 MCL1 Biology (General) QH301-705.5
spellingShingle	melanoma mitochondria SOX2 SIRT3 MCL1 Biology (General) QH301-705.5 Christina Huang Rakan H. Radi Jack L. Arbiser Mitochondrial Metabolism in Melanoma
description	Melanoma and its associated alterations in cellular pathways have been growing areas of interest in research, especially as specific biological pathways are being elucidated. Some of these alterations include changes in the mitochondrial metabolism in melanoma. Many mitochondrial metabolic changes lead to differences in the survivability of cancer cells and confer resistance to targeted therapies. While extensive work has gone into characterizing mechanisms of resistance, the role of mitochondrial adaptation as a mode of resistance is not completely understood. In this review, we wish to explore mitochondrial metabolism in melanoma and how it impacts modes of resistance. There are several genes that play a major role in melanoma mitochondrial metabolism which require a full understanding to optimally target melanoma. These include BRAF, CRAF, SOX2, MCL1, TRAP1, RHOA, SRF, SIRT3, PTEN, and AKT1. We will be discussing the role of these genes in melanoma in greater detail. An enhanced understanding of mitochondrial metabolism and these modes of resistance may result in novel combinatorial and sequential therapies that may lead to greater therapeutic benefit.
format	article
author	Christina Huang Rakan H. Radi Jack L. Arbiser
author_facet	Christina Huang Rakan H. Radi Jack L. Arbiser
author_sort	Christina Huang
title	Mitochondrial Metabolism in Melanoma
title_short	Mitochondrial Metabolism in Melanoma
title_full	Mitochondrial Metabolism in Melanoma
title_fullStr	Mitochondrial Metabolism in Melanoma
title_full_unstemmed	Mitochondrial Metabolism in Melanoma
title_sort	mitochondrial metabolism in melanoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ca3f080f46114f289e311f38e48f9e2f
work_keys_str_mv	AT christinahuang mitochondrialmetabolisminmelanoma AT rakanhradi mitochondrialmetabolisminmelanoma AT jacklarbiser mitochondrialmetabolisminmelanoma
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Mitochondrial Metabolism in Melanoma

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