Abbreviated (8 hours) versus Traditional (24 hours) Postpartum MgSO4 Prophylaxis in Severe Preeclampsia: A Randomised Control Trial
Introduction: Preeclampsia is a multisystem disorder affecting pregnancy after 20 weeks of gestation featured by hypertension and proteinuria. Magnesium Sulphate (MgSO4 ) has been used for 24 hours following delivery to prevent eclampsia in patients with severe preeclampsia. Aim: To determine...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
JCDR Research and Publications Private Limited
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/ca41bc70f6514b9487317e7e74805862 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| Sumario: | Introduction: Preeclampsia is a multisystem disorder affecting
pregnancy after 20 weeks of gestation featured by hypertension
and proteinuria. Magnesium Sulphate (MgSO4
) has been used
for 24 hours following delivery to prevent eclampsia in patients
with severe preeclampsia.
Aim: To determine the need to continue magnesium sulphate
therapy 8 hours following delivery.
Materials and Methods: The double blinded randomised controlled
study was performed in the Department of Gynaecology and
Obstetrics at R.G. Kar Medical College, Kolkata, West Bengal,
India, from 1st July 2015 to 30th June 2016. Total 90 patients with
severe preeclampsia were randomised in two group. In group A
MgSO4
was discontinued 8 hours following delivery (abbreviated
group) and in the group B it was continued for 24 hours following
delivery (traditional group). The primary objective of study was to
determine the need to continue MgSO4 therapy 8 hours following
delivery. Secondary objectives were monitoring time by doctors,
nursing care time, postpartum ambulation time, duration of urinary
catheterisation, minor complication like urinary tract infection,
duration and total dose of MgSO4
therapy. In order to calculate
statistical significance of the different variables in between two
groups, Student’s independent sample’s t-test was used for
normally distributed numerical values and Chi-square test or
Fischer’s-exact test was used for unpaired proportion data.
Results: In abbreviated group, the number of patients (n=1) who
did not need to continue MgSO4
therapy beyond 8 hours following
delivery as safety measures were statistically significant (p-value
<0.0001) in comparison to traditional group. Total duration and
dose of MgSO4
therapy were significantly less (p-value <0.0001)
in the abbreviated group. There was statistically significant
reduction in time from delivery to postpartum ambulation and
duration of indwelling urinary catheter in the abbreviated group.
Conclusion: The abbreviated (8 hours) regime of postpartum
MgSO4
for seizure prophylaxis is a suitable alternative to the
traditional (24 hours) regime. |
|---|