Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen

There is a need forPlasmodium transmission blocking drugs for malaria elimination. Here, Miguel-Blanco et al. screen >10,000 compounds against stage V female gametocytes, identify active compounds belonging to 57 chemotypes and confirm transmission blocking activity of four selected compounds in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Celia Miguel-Blanco, Irene Molina, Ana I. Bardera, Beatriz Díaz, Laura de las Heras, Sonia Lozano, Carolina González, Janneth Rodrigues, Michael J. Delves, Andrea Ruecker, Gonzalo Colmenarejo, Sara Viera, María S. Martínez-Martínez, Esther Fernández, Jake Baum, Robert E. Sinden, Esperanza Herreros
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ca4505d3d02c492988049e0313f6978a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ca4505d3d02c492988049e0313f6978a
record_format	dspace
spelling	oai:doaj.org-article:ca4505d3d02c492988049e0313f6978a2021-12-02T15:37:05ZHundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen10.1038/ncomms151602041-1723https://doaj.org/article/ca4505d3d02c492988049e0313f6978a2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15160https://doaj.org/toc/2041-1723There is a need forPlasmodium transmission blocking drugs for malaria elimination. Here, Miguel-Blanco et al. screen >10,000 compounds against stage V female gametocytes, identify active compounds belonging to 57 chemotypes and confirm transmission blocking activity of four selected compounds in vitro.Celia Miguel-BlancoIrene MolinaAna I. BarderaBeatriz DíazLaura de las HerasSonia LozanoCarolina GonzálezJanneth RodriguesMichael J. DelvesAndrea RueckerGonzalo ColmenarejoSara VieraMaría S. Martínez-MartínezEsther FernándezJake BaumRobert E. SindenEsperanza HerrerosNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Celia Miguel-Blanco Irene Molina Ana I. Bardera Beatriz Díaz Laura de las Heras Sonia Lozano Carolina González Janneth Rodrigues Michael J. Delves Andrea Ruecker Gonzalo Colmenarejo Sara Viera María S. Martínez-Martínez Esther Fernández Jake Baum Robert E. Sinden Esperanza Herreros Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen
description	There is a need forPlasmodium transmission blocking drugs for malaria elimination. Here, Miguel-Blanco et al. screen >10,000 compounds against stage V female gametocytes, identify active compounds belonging to 57 chemotypes and confirm transmission blocking activity of four selected compounds in vitro.
format	article
author	Celia Miguel-Blanco Irene Molina Ana I. Bardera Beatriz Díaz Laura de las Heras Sonia Lozano Carolina González Janneth Rodrigues Michael J. Delves Andrea Ruecker Gonzalo Colmenarejo Sara Viera María S. Martínez-Martínez Esther Fernández Jake Baum Robert E. Sinden Esperanza Herreros
author_facet	Celia Miguel-Blanco Irene Molina Ana I. Bardera Beatriz Díaz Laura de las Heras Sonia Lozano Carolina González Janneth Rodrigues Michael J. Delves Andrea Ruecker Gonzalo Colmenarejo Sara Viera María S. Martínez-Martínez Esther Fernández Jake Baum Robert E. Sinden Esperanza Herreros
author_sort	Celia Miguel-Blanco
title	Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen
title_short	Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen
title_full	Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen
title_fullStr	Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen
title_full_unstemmed	Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen
title_sort	hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ca4505d3d02c492988049e0313f6978a
work_keys_str_mv	AT celiamiguelblanco hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT irenemolina hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT anaibardera hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT beatrizdiaz hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT lauradelasheras hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT sonialozano hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT carolinagonzalez hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT jannethrodrigues hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT michaeljdelves hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT andrearuecker hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT gonzalocolmenarejo hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT saraviera hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT mariasmartinezmartinez hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT estherfernandez hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT jakebaum hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT robertesinden hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen AT esperanzaherreros hundredsofdualstageantimalarialmoleculesdiscoveredbyafunctionalgametocytescreen
_version_	1718386258927943680

Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen

Ejemplares similares