Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects

One challenge in drug screening for neurological disorders is how to accurately capture disease pathology and side effects. Here, the authors developed a multi-channel recording platform based on a zebrafish genetic model of epilepsy to screen for antiepileptic drugs.

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Autores principales:	Peter M. Eimon, Mostafa Ghannad-Rezaie, Gianluca De Rienzo, Amin Allalou, Yuelong Wu, Mu Gao, Ambrish Roy, Jeffrey Skolnick, Mehmet Fatih Yanik
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ca48ead3c4314e8da4bd2a2868831cfd
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spelling	oai:doaj.org-article:ca48ead3c4314e8da4bd2a2868831cfd2021-12-02T15:33:46ZBrain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects10.1038/s41467-017-02404-42041-1723https://doaj.org/article/ca48ead3c4314e8da4bd2a2868831cfd2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02404-4https://doaj.org/toc/2041-1723One challenge in drug screening for neurological disorders is how to accurately capture disease pathology and side effects. Here, the authors developed a multi-channel recording platform based on a zebrafish genetic model of epilepsy to screen for antiepileptic drugs.Peter M. EimonMostafa Ghannad-RezaieGianluca De RienzoAmin AllalouYuelong WuMu GaoAmbrish RoyJeffrey SkolnickMehmet Fatih YanikNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peter M. Eimon Mostafa Ghannad-Rezaie Gianluca De Rienzo Amin Allalou Yuelong Wu Mu Gao Ambrish Roy Jeffrey Skolnick Mehmet Fatih Yanik Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects
description	One challenge in drug screening for neurological disorders is how to accurately capture disease pathology and side effects. Here, the authors developed a multi-channel recording platform based on a zebrafish genetic model of epilepsy to screen for antiepileptic drugs.
format	article
author	Peter M. Eimon Mostafa Ghannad-Rezaie Gianluca De Rienzo Amin Allalou Yuelong Wu Mu Gao Ambrish Roy Jeffrey Skolnick Mehmet Fatih Yanik
author_facet	Peter M. Eimon Mostafa Ghannad-Rezaie Gianluca De Rienzo Amin Allalou Yuelong Wu Mu Gao Ambrish Roy Jeffrey Skolnick Mehmet Fatih Yanik
author_sort	Peter M. Eimon
title	Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects
title_short	Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects
title_full	Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects
title_fullStr	Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects
title_full_unstemmed	Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects
title_sort	brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ca48ead3c4314e8da4bd2a2868831cfd
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Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects

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