Evolutionary mode and functional divergence of vertebrate NMDA receptor subunit 2 genes.

<h4>Background</h4>Ionotropic glutamate receptors in the central nervous system play a major role in numerous brain functions including learning and memory in many vertebrate species. NR2 subunits have been regarded as rate-limiting molecules in controlling the optimal N-methyl-D-asparta...

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Autores principales:	Huajing Teng, Wanshi Cai, LingLin Zhou, Jing Zhang, Qi Liu, Yongqing Wang, Wei Dai, Mei Zhao, Zhongsheng Sun
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca4fd3ccf41d47268b58071897469b36
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spelling	oai:doaj.org-article:ca4fd3ccf41d47268b58071897469b362021-11-18T07:03:17ZEvolutionary mode and functional divergence of vertebrate NMDA receptor subunit 2 genes.1932-620310.1371/journal.pone.0013342https://doaj.org/article/ca4fd3ccf41d47268b58071897469b362010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20976280/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Ionotropic glutamate receptors in the central nervous system play a major role in numerous brain functions including learning and memory in many vertebrate species. NR2 subunits have been regarded as rate-limiting molecules in controlling the optimal N-methyl-D-aspartate (NMDA) receptor's coincidence-detection property and subsequent learning and memory function across multi-species. However, its evolutionary mode among vertebrate species remains unclear.<h4>Results</h4>With extensive analysis of phylogeny, exon structure, protein domain, paralogon and synteny, we demonstrated that two-round genome duplication generated quartet GRIN2 genes and the third-round fish-specific genome duplication generated extra copies of fish GRIN2 genes. In addition, in-depth investigation has enabled the identification of three novel genes, GRIN2C_Gg, GRIN2D-1_Ol and GRIN2D-2_Tr in the chicken, medaka and fugu genome, respectively. Furthermore, we showed functional divergence of NR2 genes mostly occurred at the first-round duplication, amino acid residues located at the N-terminal Lig_chan domain were responsible for type I functional divergence between these GRIN2 subfamilies and purifying selection has been the prominent natural pressure operating on these diversified GRIN2 genes.<h4>Conclusion and significance</h4>These findings provide intriguing subjects for testing the 2R and 3R hypothesis and we expect it could provide new insights into the underlying evolution mechanisms of cognition in vertebrate.Huajing TengWanshi CaiLingLin ZhouJing ZhangQi LiuYongqing WangWei DaiMei ZhaoZhongsheng SunPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 10, p e13342 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huajing Teng Wanshi Cai LingLin Zhou Jing Zhang Qi Liu Yongqing Wang Wei Dai Mei Zhao Zhongsheng Sun Evolutionary mode and functional divergence of vertebrate NMDA receptor subunit 2 genes.
description	<h4>Background</h4>Ionotropic glutamate receptors in the central nervous system play a major role in numerous brain functions including learning and memory in many vertebrate species. NR2 subunits have been regarded as rate-limiting molecules in controlling the optimal N-methyl-D-aspartate (NMDA) receptor's coincidence-detection property and subsequent learning and memory function across multi-species. However, its evolutionary mode among vertebrate species remains unclear.<h4>Results</h4>With extensive analysis of phylogeny, exon structure, protein domain, paralogon and synteny, we demonstrated that two-round genome duplication generated quartet GRIN2 genes and the third-round fish-specific genome duplication generated extra copies of fish GRIN2 genes. In addition, in-depth investigation has enabled the identification of three novel genes, GRIN2C_Gg, GRIN2D-1_Ol and GRIN2D-2_Tr in the chicken, medaka and fugu genome, respectively. Furthermore, we showed functional divergence of NR2 genes mostly occurred at the first-round duplication, amino acid residues located at the N-terminal Lig_chan domain were responsible for type I functional divergence between these GRIN2 subfamilies and purifying selection has been the prominent natural pressure operating on these diversified GRIN2 genes.<h4>Conclusion and significance</h4>These findings provide intriguing subjects for testing the 2R and 3R hypothesis and we expect it could provide new insights into the underlying evolution mechanisms of cognition in vertebrate.
format	article
author	Huajing Teng Wanshi Cai LingLin Zhou Jing Zhang Qi Liu Yongqing Wang Wei Dai Mei Zhao Zhongsheng Sun
author_facet	Huajing Teng Wanshi Cai LingLin Zhou Jing Zhang Qi Liu Yongqing Wang Wei Dai Mei Zhao Zhongsheng Sun
author_sort	Huajing Teng
title	Evolutionary mode and functional divergence of vertebrate NMDA receptor subunit 2 genes.
title_short	Evolutionary mode and functional divergence of vertebrate NMDA receptor subunit 2 genes.
title_full	Evolutionary mode and functional divergence of vertebrate NMDA receptor subunit 2 genes.
title_fullStr	Evolutionary mode and functional divergence of vertebrate NMDA receptor subunit 2 genes.
title_full_unstemmed	Evolutionary mode and functional divergence of vertebrate NMDA receptor subunit 2 genes.
title_sort	evolutionary mode and functional divergence of vertebrate nmda receptor subunit 2 genes.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/ca4fd3ccf41d47268b58071897469b36
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Evolutionary mode and functional divergence of vertebrate NMDA receptor subunit 2 genes.

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