Optimizing Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction During Hospitalization

Heart failure remains a huge societal concern despite medical advancement, with an annual direct cost of over $30 billion. While guideline-directed medical therapy (GDMT) is proven to reduce morbidity and mortality, many eligible patients with heart failure with reduced ejection fraction (HFrEF) are...

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Autores principales:	Neal M Dixit, Shivani Shah, Boback Ziaeian, Gregg C Fonarow, Jeffrey J Hsu
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/ca54115097ca404abb834a9b50fca39c
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spelling	oai:doaj.org-article:ca54115097ca404abb834a9b50fca39c2021-12-04T16:04:21ZOptimizing Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction During Hospitalization10.15420/usc.2020.291758-390X1758-3896https://doaj.org/article/ca54115097ca404abb834a9b50fca39c2021-04-01T00:00:00Zhttps://www.uscjournal.com/articleindex/usc.2020.29https://doaj.org/toc/1758-3896https://doaj.org/toc/1758-390XHeart failure remains a huge societal concern despite medical advancement, with an annual direct cost of over $30 billion. While guideline-directed medical therapy (GDMT) is proven to reduce morbidity and mortality, many eligible patients with heart failure with reduced ejection fraction (HFrEF) are not receiving one or more of the recommended medications, often due to suboptimal initiation and titration in the outpatient setting. Hospitalization serves as a key point to initiate and titrate GDMT. Four evidence-based therapies have clinical benefit within 30 days of initiation and form a crucial foundation for HFrEF therapy: renin-angiotensin-aldosterone system inhibitors with or without a neprilysin inhibitor, β-blockers, mineralocorticoid-receptor-antagonists, and sodium-glucose cotransporter-2 inhibitors. The authors present a practical guide for the implementation of these four pillars of GDMT during a hospitalization for acute heart failure.Neal M DixitShivani ShahBoback ZiaeianGregg C FonarowJeffrey J HsuRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENUS Cardiology Review , Vol 15, Iss , Pp - (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Neal M Dixit Shivani Shah Boback Ziaeian Gregg C Fonarow Jeffrey J Hsu Optimizing Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction During Hospitalization
description	Heart failure remains a huge societal concern despite medical advancement, with an annual direct cost of over $30 billion. While guideline-directed medical therapy (GDMT) is proven to reduce morbidity and mortality, many eligible patients with heart failure with reduced ejection fraction (HFrEF) are not receiving one or more of the recommended medications, often due to suboptimal initiation and titration in the outpatient setting. Hospitalization serves as a key point to initiate and titrate GDMT. Four evidence-based therapies have clinical benefit within 30 days of initiation and form a crucial foundation for HFrEF therapy: renin-angiotensin-aldosterone system inhibitors with or without a neprilysin inhibitor, β-blockers, mineralocorticoid-receptor-antagonists, and sodium-glucose cotransporter-2 inhibitors. The authors present a practical guide for the implementation of these four pillars of GDMT during a hospitalization for acute heart failure.
format	article
author	Neal M Dixit Shivani Shah Boback Ziaeian Gregg C Fonarow Jeffrey J Hsu
author_facet	Neal M Dixit Shivani Shah Boback Ziaeian Gregg C Fonarow Jeffrey J Hsu
author_sort	Neal M Dixit
title	Optimizing Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction During Hospitalization
title_short	Optimizing Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction During Hospitalization
title_full	Optimizing Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction During Hospitalization
title_fullStr	Optimizing Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction During Hospitalization
title_full_unstemmed	Optimizing Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction During Hospitalization
title_sort	optimizing guideline-directed medical therapies for heart failure with reduced ejection fraction during hospitalization
publisher	Radcliffe Medical Media
publishDate	2021
url	https://doaj.org/article/ca54115097ca404abb834a9b50fca39c
work_keys_str_mv	AT nealmdixit optimizingguidelinedirectedmedicaltherapiesforheartfailurewithreducedejectionfractionduringhospitalization AT shivanishah optimizingguidelinedirectedmedicaltherapiesforheartfailurewithreducedejectionfractionduringhospitalization AT bobackziaeian optimizingguidelinedirectedmedicaltherapiesforheartfailurewithreducedejectionfractionduringhospitalization AT greggcfonarow optimizingguidelinedirectedmedicaltherapiesforheartfailurewithreducedejectionfractionduringhospitalization AT jeffreyjhsu optimizingguidelinedirectedmedicaltherapiesforheartfailurewithreducedejectionfractionduringhospitalization
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Optimizing Guideline-directed Medical Therapies for Heart Failure with Reduced Ejection Fraction During Hospitalization

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