MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists

MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists

MicroRNAs play an important role in stem cell fate and tumorigenesis. In this work, the authors show that miR-31 controls mammary stem cell self-renewal and tumorigenesis by simultaneously activating Wnt/β-catenin and repressing TGFβ signaling pathways.

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Autores principales: Cong Lv, Fengyin Li, Xiang Li, Yuhua Tian, Yue Zhang, Xiaole Sheng, Yongli Song, Qingyong Meng, Shukai Yuan, Liming Luan, Thomas Andl, Xu Feng, Baowei Jiao, Mingang Xu, Maksim V. Plikus, Xing Dai, Christopher Lengner, Wei Cui, Fazheng Ren, Jianwei Shuai, Sarah E. Millar, Zhengquan Yu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
Q
Acceso en línea:https://doaj.org/article/ca55349c2f9c4d529171e92fed21d469
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spelling oai:doaj.org-article:ca55349c2f9c4d529171e92fed21d4692021-12-02T14:42:17ZMiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists10.1038/s41467-017-01059-52041-1723https://doaj.org/article/ca55349c2f9c4d529171e92fed21d4692017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01059-5https://doaj.org/toc/2041-1723MicroRNAs play an important role in stem cell fate and tumorigenesis. In this work, the authors show that miR-31 controls mammary stem cell self-renewal and tumorigenesis by simultaneously activating Wnt/β-catenin and repressing TGFβ signaling pathways.Cong LvFengyin LiXiang LiYuhua TianYue ZhangXiaole ShengYongli SongQingyong MengShukai YuanLiming LuanThomas AndlXu FengBaowei JiaoMingang XuMaksim V. PlikusXing DaiChristopher LengnerWei CuiFazheng RenJianwei ShuaiSarah E. MillarZhengquan YuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Cong Lv
Fengyin Li
Xiang Li
Yuhua Tian
Yue Zhang
Xiaole Sheng
Yongli Song
Qingyong Meng
Shukai Yuan
Liming Luan
Thomas Andl
Xu Feng
Baowei Jiao
Mingang Xu
Maksim V. Plikus
Xing Dai
Christopher Lengner
Wei Cui
Fazheng Ren
Jianwei Shuai
Sarah E. Millar
Zhengquan Yu
MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists
description MicroRNAs play an important role in stem cell fate and tumorigenesis. In this work, the authors show that miR-31 controls mammary stem cell self-renewal and tumorigenesis by simultaneously activating Wnt/β-catenin and repressing TGFβ signaling pathways.
format article
author Cong Lv
Fengyin Li
Xiang Li
Yuhua Tian
Yue Zhang
Xiaole Sheng
Yongli Song
Qingyong Meng
Shukai Yuan
Liming Luan
Thomas Andl
Xu Feng
Baowei Jiao
Mingang Xu
Maksim V. Plikus
Xing Dai
Christopher Lengner
Wei Cui
Fazheng Ren
Jianwei Shuai
Sarah E. Millar
Zhengquan Yu
author_facet Cong Lv
Fengyin Li
Xiang Li
Yuhua Tian
Yue Zhang
Xiaole Sheng
Yongli Song
Qingyong Meng
Shukai Yuan
Liming Luan
Thomas Andl
Xu Feng
Baowei Jiao
Mingang Xu
Maksim V. Plikus
Xing Dai
Christopher Lengner
Wei Cui
Fazheng Ren
Jianwei Shuai
Sarah E. Millar
Zhengquan Yu
author_sort Cong Lv
title MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists
title_short MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists
title_full MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists
title_fullStr MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists
title_full_unstemmed MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists
title_sort mir-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing wnt signaling antagonists
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/ca55349c2f9c4d529171e92fed21d469
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