Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation

Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation

Context Severe nephrotoxicity greatly limits the clinical use of the common effective chemotherapeutic agent cyclophosphamide (CYP). Huaiqihuang (HQH) is a Chinese herbal complex with various pharmacological activities, widely used for treating kidney disease. Objective This study estimates the prot...

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Autores principales: Yueming Zhang, Jian Chang, Huan Gao, Xiaoyu Qu, Jinghui Zhai, Lina Tao, Jingmeng Sun, Yanqing Song
Formato: article
Lenguaje:EN
Publicado: Taylor & Francis Group 2021
Materias:
chinese medicine
chemotherapeutic agent
oxidative stress
apoptosis
inflammation
Therapeutics. Pharmacology
RM1-950
Acceso en línea:https://doaj.org/article/ca57ac7432d9427d8ee9d317979cfbc5
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