Metagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants

Abstract Early childhood is a critical stage for the foundation and development of the gut microbiome, large amounts of essential nutrients are required such as vitamin D. Vitamin D plays an important role in regulating calcium homeostasis, and deficiency can impair bone mineralization. In addition,...

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Autores principales:	Wei-Te Lei, Kai-Yao Huang, Jhih-Hua Jhong, Chia-Hung Chen, Shun-Long Weng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca5bf07fa5b748719c9a2e85c55f255f
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spelling	oai:doaj.org-article:ca5bf07fa5b748719c9a2e85c55f255f2021-12-02T14:06:49ZMetagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants10.1038/s41598-021-82584-82045-2322https://doaj.org/article/ca5bf07fa5b748719c9a2e85c55f255f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82584-8https://doaj.org/toc/2045-2322Abstract Early childhood is a critical stage for the foundation and development of the gut microbiome, large amounts of essential nutrients are required such as vitamin D. Vitamin D plays an important role in regulating calcium homeostasis, and deficiency can impair bone mineralization. In addition, most people know that breastfeeding is advocated to be the best thing for a newborn; however, exclusively breastfeeding infants are not easily able to absorb an adequate amount of vitamin D from breast milk. Understanding the effects of vitamin D supplementation on gut microbiome can improve the knowledge of infant health and development. A total of 62 fecal sample from healthy infants were collected in Taiwan. Of the 62 infants, 31 were exclusively breastfed infants and 31 were mixed- or formula-fed infants. For each feeding type, one subgroup of infants received 400 IU of vitamin D per day, and the remaining infants received a placebo. In total, there are 15 breastfed and 20 formula-fed infants with additional vitamin D supplementation, and 16 breastfed and 11 formula-fed infants belong to control group, respectively. We performed a comparative metagenomic analysis to investigate the distribution and diversity of infant gut microbiota among different types of feeding regimes with and without vitamin D supplementation. Our results reveal that the characteristics of infant gut microbiota not only depend on the feeding types but also on nutrients intake, and demonstrated that the vitamin D plays an important role in modulating the infant gut microbiota, especially increase the proportion of probiotics in breast-fed infants.Wei-Te LeiKai-Yao HuangJhih-Hua JhongChia-Hung ChenShun-Long WengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wei-Te Lei Kai-Yao Huang Jhih-Hua Jhong Chia-Hung Chen Shun-Long Weng Metagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants
description	Abstract Early childhood is a critical stage for the foundation and development of the gut microbiome, large amounts of essential nutrients are required such as vitamin D. Vitamin D plays an important role in regulating calcium homeostasis, and deficiency can impair bone mineralization. In addition, most people know that breastfeeding is advocated to be the best thing for a newborn; however, exclusively breastfeeding infants are not easily able to absorb an adequate amount of vitamin D from breast milk. Understanding the effects of vitamin D supplementation on gut microbiome can improve the knowledge of infant health and development. A total of 62 fecal sample from healthy infants were collected in Taiwan. Of the 62 infants, 31 were exclusively breastfed infants and 31 were mixed- or formula-fed infants. For each feeding type, one subgroup of infants received 400 IU of vitamin D per day, and the remaining infants received a placebo. In total, there are 15 breastfed and 20 formula-fed infants with additional vitamin D supplementation, and 16 breastfed and 11 formula-fed infants belong to control group, respectively. We performed a comparative metagenomic analysis to investigate the distribution and diversity of infant gut microbiota among different types of feeding regimes with and without vitamin D supplementation. Our results reveal that the characteristics of infant gut microbiota not only depend on the feeding types but also on nutrients intake, and demonstrated that the vitamin D plays an important role in modulating the infant gut microbiota, especially increase the proportion of probiotics in breast-fed infants.
format	article
author	Wei-Te Lei Kai-Yao Huang Jhih-Hua Jhong Chia-Hung Chen Shun-Long Weng
author_facet	Wei-Te Lei Kai-Yao Huang Jhih-Hua Jhong Chia-Hung Chen Shun-Long Weng
author_sort	Wei-Te Lei
title	Metagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants
title_short	Metagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants
title_full	Metagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants
title_fullStr	Metagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants
title_full_unstemmed	Metagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants
title_sort	metagenomic analysis of the gut microbiome composition associated with vitamin d supplementation in taiwanese infants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ca5bf07fa5b748719c9a2e85c55f255f
work_keys_str_mv	AT weitelei metagenomicanalysisofthegutmicrobiomecompositionassociatedwithvitamindsupplementationintaiwaneseinfants AT kaiyaohuang metagenomicanalysisofthegutmicrobiomecompositionassociatedwithvitamindsupplementationintaiwaneseinfants AT jhihhuajhong metagenomicanalysisofthegutmicrobiomecompositionassociatedwithvitamindsupplementationintaiwaneseinfants AT chiahungchen metagenomicanalysisofthegutmicrobiomecompositionassociatedwithvitamindsupplementationintaiwaneseinfants AT shunlongweng metagenomicanalysisofthegutmicrobiomecompositionassociatedwithvitamindsupplementationintaiwaneseinfants
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Metagenomic analysis of the gut microbiome composition associated with vitamin D supplementation in Taiwanese infants

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