Quantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects
Abstract We present a quantitative study of different molecular iron forms found in the temporal cortex of Alzheimer (AD) patients. Applying the methodology we developed in our previous work, we quantify the concentrations of non-heme Fe(III) by Electron Paramagnetic Resonance (EPR), magnetite/maghe...
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Nature Portfolio
2018
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oai:doaj.org-article:ca5d833c383f4fb99d830cbd3a160c332021-12-02T12:32:47ZQuantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects10.1038/s41598-018-25021-72045-2322https://doaj.org/article/ca5d833c383f4fb99d830cbd3a160c332018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25021-7https://doaj.org/toc/2045-2322Abstract We present a quantitative study of different molecular iron forms found in the temporal cortex of Alzheimer (AD) patients. Applying the methodology we developed in our previous work, we quantify the concentrations of non-heme Fe(III) by Electron Paramagnetic Resonance (EPR), magnetite/maghemite and ferrihydrite by SQUID magnetometry, together with the MRI transverse relaxation rate $$({{\rm{R}}}_{2}^{\ast })$$ (R2⁎) , to obtain a systematic view of molecular iron in the temporal cortex. Significantly higher values of $${{\rm{R}}}_{2}^{\ast }$$ R2⁎ , a larger concentration of ferrihydrite, and a larger magnetic moment of magnetite/maghemite particles are found in the brain of AD patients. Moreover, we found correlations between the concentration of the iron detected by EPR, the concentration of the ferrihydrite mineral and the average iron loading of ferritin. We discuss these findings in the framework of iron dis-homeostasis, which has been proposed to occur in the brain of AD patients.Marjolein BulkLouise van der WeerdWico BreimerNikita LebedevAndrew WebbJelle J. GoemanRoberta J. WardMartina HuberTjerk H. OosterkampLucia BossoniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018) |
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Medicine R Science Q Marjolein Bulk Louise van der Weerd Wico Breimer Nikita Lebedev Andrew Webb Jelle J. Goeman Roberta J. Ward Martina Huber Tjerk H. Oosterkamp Lucia Bossoni Quantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects |
| description |
Abstract We present a quantitative study of different molecular iron forms found in the temporal cortex of Alzheimer (AD) patients. Applying the methodology we developed in our previous work, we quantify the concentrations of non-heme Fe(III) by Electron Paramagnetic Resonance (EPR), magnetite/maghemite and ferrihydrite by SQUID magnetometry, together with the MRI transverse relaxation rate $$({{\rm{R}}}_{2}^{\ast })$$ (R2⁎) , to obtain a systematic view of molecular iron in the temporal cortex. Significantly higher values of $${{\rm{R}}}_{2}^{\ast }$$ R2⁎ , a larger concentration of ferrihydrite, and a larger magnetic moment of magnetite/maghemite particles are found in the brain of AD patients. Moreover, we found correlations between the concentration of the iron detected by EPR, the concentration of the ferrihydrite mineral and the average iron loading of ferritin. We discuss these findings in the framework of iron dis-homeostasis, which has been proposed to occur in the brain of AD patients. |
| format |
article |
| author |
Marjolein Bulk Louise van der Weerd Wico Breimer Nikita Lebedev Andrew Webb Jelle J. Goeman Roberta J. Ward Martina Huber Tjerk H. Oosterkamp Lucia Bossoni |
| author_facet |
Marjolein Bulk Louise van der Weerd Wico Breimer Nikita Lebedev Andrew Webb Jelle J. Goeman Roberta J. Ward Martina Huber Tjerk H. Oosterkamp Lucia Bossoni |
| author_sort |
Marjolein Bulk |
| title |
Quantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects |
| title_short |
Quantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects |
| title_full |
Quantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects |
| title_fullStr |
Quantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects |
| title_full_unstemmed |
Quantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects |
| title_sort |
quantitative comparison of different iron forms in the temporal cortex of alzheimer patients and control subjects |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/ca5d833c383f4fb99d830cbd3a160c33 |
| work_keys_str_mv |
AT marjoleinbulk quantitativecomparisonofdifferentironformsinthetemporalcortexofalzheimerpatientsandcontrolsubjects AT louisevanderweerd quantitativecomparisonofdifferentironformsinthetemporalcortexofalzheimerpatientsandcontrolsubjects AT wicobreimer quantitativecomparisonofdifferentironformsinthetemporalcortexofalzheimerpatientsandcontrolsubjects AT nikitalebedev quantitativecomparisonofdifferentironformsinthetemporalcortexofalzheimerpatientsandcontrolsubjects AT andrewwebb quantitativecomparisonofdifferentironformsinthetemporalcortexofalzheimerpatientsandcontrolsubjects AT jellejgoeman quantitativecomparisonofdifferentironformsinthetemporalcortexofalzheimerpatientsandcontrolsubjects AT robertajward quantitativecomparisonofdifferentironformsinthetemporalcortexofalzheimerpatientsandcontrolsubjects AT martinahuber quantitativecomparisonofdifferentironformsinthetemporalcortexofalzheimerpatientsandcontrolsubjects AT tjerkhoosterkamp quantitativecomparisonofdifferentironformsinthetemporalcortexofalzheimerpatientsandcontrolsubjects AT luciabossoni quantitativecomparisonofdifferentironformsinthetemporalcortexofalzheimerpatientsandcontrolsubjects |
| _version_ |
1718394005590376448 |