808 nm Near-Infrared Light-Excited UCNPs@mSiO2-Ce6-GPC3 Nanocomposites For Photodynamic Therapy In Liver Cancer
Jiahe Hu,1,* Jialan Shi,2,3 Yingqian Gao,1 Wei Yang,1 Ping Liu,1 Qinghao Liu,1 Fei He,4 Chunxu Wang,2 Tao Li,2 Rui Xie,1 Jiuxin Zhu,5 Piaoping Yang4,* 1Department of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People’s Republic of China; 2Departme...
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Dove Medical Press
2019
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oai:doaj.org-article:ca5dcd9cef1147eeb429e1fdf356500c2021-12-02T09:04:20Z808 nm Near-Infrared Light-Excited UCNPs@mSiO2-Ce6-GPC3 Nanocomposites For Photodynamic Therapy In Liver Cancer1178-2013https://doaj.org/article/ca5dcd9cef1147eeb429e1fdf356500c2019-12-01T00:00:00Zhttps://www.dovepress.com/808-nm-near-infrared-light-excited-ucnpsmsio2-ce6-gpc3-nanocomposites--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jiahe Hu,1,* Jialan Shi,2,3 Yingqian Gao,1 Wei Yang,1 Ping Liu,1 Qinghao Liu,1 Fei He,4 Chunxu Wang,2 Tao Li,2 Rui Xie,1 Jiuxin Zhu,5 Piaoping Yang4,* 1Department of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People’s Republic of China; 2Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, People’s Republic of China; 3Department of Surgery, VA Boston Healthcare System, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 12132, USA; 4Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, People’s Republic of China; 5Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratories of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiuxin ZhuDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratories of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, People’s Republic of ChinaTel +86 15104557900Email zhujiuxin@hrbmu.edu.cnRui XieDepartment of Digestive Internal Medicine Harbin Medical University Cancer Hospital, 150 Haping Road, Nangang District, Heilongjiang, Harbin 150081, People’s Republic of ChinaTel +86 13845098117Email rxie@hrbmu.edu.cnBackground: It is important to explore effective treatment for liver cancer. Photodynamic therapy (PDT) is a novel technique to treat liver cancer, but its clinical application is obstructed by limited depth of visible light penetration into tissue. The near-infrared (NIR) photosensitizer is a potential solution to the limitations of PDT for deep tumor tissue treatment.Purpose: We aimed to investigate 808 nm NIR light-excited UCNPs@mSiO2-Ce6-GPC3 nanocomposites for PDT in liver cancer.Methods: In our study, 808 nm NIR light-excited upconversion nanoparticles (UCNPs) were simultaneously loaded with the photosensitizer chlorin e6 (Ce6) and the antibody glypican-3 (GPC3), which is overexpressed in hepatocellular carcinoma cells. The multitasking UCNPs@mSiO2-Ce6-GPC3 nanoparticles under 808 nm laser irradiation with enhanced depth of penetration would enable the effective targeting of PDT.Results: We found that the UCNPs@mSiO2-Ce6-GPC3 nanoparticles had good biocompatibility, low toxicity, excellent cell imaging in HepG2 cancer cells and high anti-tumor effect in vitro and in vivo.Conclusion: We believe that the utilization of 808 nm NIR excited UCNPs@mSiO2-Ce6-GPC3 nanoparticles for PDT is a safe and potential therapeutic option for liver cancer.Keywords: liver cancer, photodynamic therapy, upconversion nanoparticles, 808 nm NIR, GPC3, targeted therapyHu JShi JGao YYang WLiu PLiu QHe FWang CLi TXie RZhu JYang PDove Medical Pressarticleliver cancerphotodynamic therapyupconversion nanoparticles808 nm nirgpc3targeted therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 10009-10021 (2019) |
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EN |
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liver cancer photodynamic therapy upconversion nanoparticles 808 nm nir gpc3 targeted therapy Medicine (General) R5-920 |
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liver cancer photodynamic therapy upconversion nanoparticles 808 nm nir gpc3 targeted therapy Medicine (General) R5-920 Hu J Shi J Gao Y Yang W Liu P Liu Q He F Wang C Li T Xie R Zhu J Yang P 808 nm Near-Infrared Light-Excited UCNPs@mSiO2-Ce6-GPC3 Nanocomposites For Photodynamic Therapy In Liver Cancer |
| description |
Jiahe Hu,1,* Jialan Shi,2,3 Yingqian Gao,1 Wei Yang,1 Ping Liu,1 Qinghao Liu,1 Fei He,4 Chunxu Wang,2 Tao Li,2 Rui Xie,1 Jiuxin Zhu,5 Piaoping Yang4,* 1Department of Digestive Internal Medicine, Harbin Medical University Cancer Hospital, Harbin 150081, People’s Republic of China; 2Department of Hematology, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, People’s Republic of China; 3Department of Surgery, VA Boston Healthcare System, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 12132, USA; 4Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, People’s Republic of China; 5Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratories of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiuxin ZhuDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratories of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, People’s Republic of ChinaTel +86 15104557900Email zhujiuxin@hrbmu.edu.cnRui XieDepartment of Digestive Internal Medicine Harbin Medical University Cancer Hospital, 150 Haping Road, Nangang District, Heilongjiang, Harbin 150081, People’s Republic of ChinaTel +86 13845098117Email rxie@hrbmu.edu.cnBackground: It is important to explore effective treatment for liver cancer. Photodynamic therapy (PDT) is a novel technique to treat liver cancer, but its clinical application is obstructed by limited depth of visible light penetration into tissue. The near-infrared (NIR) photosensitizer is a potential solution to the limitations of PDT for deep tumor tissue treatment.Purpose: We aimed to investigate 808 nm NIR light-excited UCNPs@mSiO2-Ce6-GPC3 nanocomposites for PDT in liver cancer.Methods: In our study, 808 nm NIR light-excited upconversion nanoparticles (UCNPs) were simultaneously loaded with the photosensitizer chlorin e6 (Ce6) and the antibody glypican-3 (GPC3), which is overexpressed in hepatocellular carcinoma cells. The multitasking UCNPs@mSiO2-Ce6-GPC3 nanoparticles under 808 nm laser irradiation with enhanced depth of penetration would enable the effective targeting of PDT.Results: We found that the UCNPs@mSiO2-Ce6-GPC3 nanoparticles had good biocompatibility, low toxicity, excellent cell imaging in HepG2 cancer cells and high anti-tumor effect in vitro and in vivo.Conclusion: We believe that the utilization of 808 nm NIR excited UCNPs@mSiO2-Ce6-GPC3 nanoparticles for PDT is a safe and potential therapeutic option for liver cancer.Keywords: liver cancer, photodynamic therapy, upconversion nanoparticles, 808 nm NIR, GPC3, targeted therapy |
| format |
article |
| author |
Hu J Shi J Gao Y Yang W Liu P Liu Q He F Wang C Li T Xie R Zhu J Yang P |
| author_facet |
Hu J Shi J Gao Y Yang W Liu P Liu Q He F Wang C Li T Xie R Zhu J Yang P |
| author_sort |
Hu J |
| title |
808 nm Near-Infrared Light-Excited UCNPs@mSiO2-Ce6-GPC3 Nanocomposites For Photodynamic Therapy In Liver Cancer |
| title_short |
808 nm Near-Infrared Light-Excited UCNPs@mSiO2-Ce6-GPC3 Nanocomposites For Photodynamic Therapy In Liver Cancer |
| title_full |
808 nm Near-Infrared Light-Excited UCNPs@mSiO2-Ce6-GPC3 Nanocomposites For Photodynamic Therapy In Liver Cancer |
| title_fullStr |
808 nm Near-Infrared Light-Excited UCNPs@mSiO2-Ce6-GPC3 Nanocomposites For Photodynamic Therapy In Liver Cancer |
| title_full_unstemmed |
808 nm Near-Infrared Light-Excited UCNPs@mSiO2-Ce6-GPC3 Nanocomposites For Photodynamic Therapy In Liver Cancer |
| title_sort |
808 nm near-infrared light-excited ucnps@msio2-ce6-gpc3 nanocomposites for photodynamic therapy in liver cancer |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/ca5dcd9cef1147eeb429e1fdf356500c |
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