Progress in micro RNA focused research in endocrinology

Micro RNAs (miRNAs) are small regulatory molecules of increasing biologists’ interest. miRNAs, unlikely mRNA, do not encode proteins. It is a class of small double stranded RNA molecules that via their seed sequence interact with mRNA and inhibit its expression. It has been estimated that 30% of hum...

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Autores principales:	Voglova K., Bezakova J., Herichova Iveta
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	risc argonaute hormone adrenal pancreas pituitary angiotensin Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/ca5fe322b1ee42c0b1e171caab88d84e
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id	oai:doaj.org-article:ca5fe322b1ee42c0b1e171caab88d84e
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spelling	oai:doaj.org-article:ca5fe322b1ee42c0b1e171caab88d84e2021-12-02T17:49:19ZProgress in micro RNA focused research in endocrinology1336-032910.1515/enr-2016-0012https://doaj.org/article/ca5fe322b1ee42c0b1e171caab88d84e2016-04-01T00:00:00Zhttps://doi.org/10.1515/enr-2016-0012https://doaj.org/toc/1336-0329Micro RNAs (miRNAs) are small regulatory molecules of increasing biologists’ interest. miRNAs, unlikely mRNA, do not encode proteins. It is a class of small double stranded RNA molecules that via their seed sequence interact with mRNA and inhibit its expression. It has been estimated that 30% of human gene expression is regulated by miRNAs. One miRNA usually targets several mRNAs and one mRNA can be regulated by several miRNAs. miRNA biogenesis is realized by key enzymes, Drosha and Dicer. miRNA/mRNA interaction depends on binding to RNA-induced silencing complex. Today, complete commercially available methodical proposals for miRNA investigation are available. There are techniques allowing the identification of new miRNAs and new miRNA targets, validation of predicted targets, measurement of miRNAs and their precursor levels, and validation of physiological role of miRNAs under in vitro and in vivo conditions. miRNAs have been shown to influence gene expression in several endocrine glands, including pancreas, ovary, testes, hypothalamus, and pituitary.Voglova K.Bezakova J.Herichova IvetaSciendoarticleriscargonautehormoneadrenalpancreaspituitaryangiotensinDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 50, Iss 2, Pp 83-105 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	risc argonaute hormone adrenal pancreas pituitary angiotensin Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	risc argonaute hormone adrenal pancreas pituitary angiotensin Diseases of the endocrine glands. Clinical endocrinology RC648-665 Voglova K. Bezakova J. Herichova Iveta Progress in micro RNA focused research in endocrinology
description	Micro RNAs (miRNAs) are small regulatory molecules of increasing biologists’ interest. miRNAs, unlikely mRNA, do not encode proteins. It is a class of small double stranded RNA molecules that via their seed sequence interact with mRNA and inhibit its expression. It has been estimated that 30% of human gene expression is regulated by miRNAs. One miRNA usually targets several mRNAs and one mRNA can be regulated by several miRNAs. miRNA biogenesis is realized by key enzymes, Drosha and Dicer. miRNA/mRNA interaction depends on binding to RNA-induced silencing complex. Today, complete commercially available methodical proposals for miRNA investigation are available. There are techniques allowing the identification of new miRNAs and new miRNA targets, validation of predicted targets, measurement of miRNAs and their precursor levels, and validation of physiological role of miRNAs under in vitro and in vivo conditions. miRNAs have been shown to influence gene expression in several endocrine glands, including pancreas, ovary, testes, hypothalamus, and pituitary.
format	article
author	Voglova K. Bezakova J. Herichova Iveta
author_facet	Voglova K. Bezakova J. Herichova Iveta
author_sort	Voglova K.
title	Progress in micro RNA focused research in endocrinology
title_short	Progress in micro RNA focused research in endocrinology
title_full	Progress in micro RNA focused research in endocrinology
title_fullStr	Progress in micro RNA focused research in endocrinology
title_full_unstemmed	Progress in micro RNA focused research in endocrinology
title_sort	progress in micro rna focused research in endocrinology
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/ca5fe322b1ee42c0b1e171caab88d84e
work_keys_str_mv	AT voglovak progressinmicrornafocusedresearchinendocrinology AT bezakovaj progressinmicrornafocusedresearchinendocrinology AT herichovaiveta progressinmicrornafocusedresearchinendocrinology
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Progress in micro RNA focused research in endocrinology

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