Altered Functional Connectivity in a Triple-Network Model in Autism With Co-occurring Attention Deficit Hyperactivity Disorder

Purpose: This study aimed to explore alterations in functional connectivity (FC) within and between default mode network (DMN), central executive network, and salience network in autism spectrum disorder (ASD) with co-occurring attention deficit hyperactivity disorder (ADHD).Method: A total of 135 i...

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Autores principales:	Kai Wang, Ke Li, Xiaoyu Niu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	autism attention deficit hyperactivity disorder co-occurring triple-network model default mode network Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/ca619c13c39541ac9ce448aeace4981c
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spelling	oai:doaj.org-article:ca619c13c39541ac9ce448aeace4981c2021-12-02T07:09:50ZAltered Functional Connectivity in a Triple-Network Model in Autism With Co-occurring Attention Deficit Hyperactivity Disorder1664-064010.3389/fpsyt.2021.736755https://doaj.org/article/ca619c13c39541ac9ce448aeace4981c2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.736755/fullhttps://doaj.org/toc/1664-0640Purpose: This study aimed to explore alterations in functional connectivity (FC) within and between default mode network (DMN), central executive network, and salience network in autism spectrum disorder (ASD) with co-occurring attention deficit hyperactivity disorder (ADHD).Method: A total of 135 individuals' date of the Autism Brain Imaging Data Exchange II was used to compare the ASD+ADHD group with the ASD group in relation to the abnormal within-network and between-network connectivity of the ASD group relative to the TD group; consequently, the correlation analysis between abnormal FC and behavior was performed.Results: The ASD+ADHD group exhibited decreased within-network connectivity in the precuneus of the ventral DMN compared with the ASD group. Among the three groups, the ASD+ADHD group showed lower connectivity, whereas the ASD group had higher connectivity than the TD group, although the effect of the separate post hoc test was not significant. Meanwhile, the ASD+ADHD group showed increased between-network connectivity between the ventral DMN and dorsal DMN and between the ventral DMN and left executive control network, compared with the ASD and TD groups.Conclusion: Dysfunction of DMN in the “triple-network model” is the core evidence for ASD with co-occurring ADHD.Kai WangKe LiXiaoyu NiuFrontiers Media S.A.articleautismattention deficit hyperactivity disorderco-occurringtriple-network modeldefault mode networkPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism attention deficit hyperactivity disorder co-occurring triple-network model default mode network Psychiatry RC435-571
spellingShingle	autism attention deficit hyperactivity disorder co-occurring triple-network model default mode network Psychiatry RC435-571 Kai Wang Ke Li Xiaoyu Niu Altered Functional Connectivity in a Triple-Network Model in Autism With Co-occurring Attention Deficit Hyperactivity Disorder
description	Purpose: This study aimed to explore alterations in functional connectivity (FC) within and between default mode network (DMN), central executive network, and salience network in autism spectrum disorder (ASD) with co-occurring attention deficit hyperactivity disorder (ADHD).Method: A total of 135 individuals' date of the Autism Brain Imaging Data Exchange II was used to compare the ASD+ADHD group with the ASD group in relation to the abnormal within-network and between-network connectivity of the ASD group relative to the TD group; consequently, the correlation analysis between abnormal FC and behavior was performed.Results: The ASD+ADHD group exhibited decreased within-network connectivity in the precuneus of the ventral DMN compared with the ASD group. Among the three groups, the ASD+ADHD group showed lower connectivity, whereas the ASD group had higher connectivity than the TD group, although the effect of the separate post hoc test was not significant. Meanwhile, the ASD+ADHD group showed increased between-network connectivity between the ventral DMN and dorsal DMN and between the ventral DMN and left executive control network, compared with the ASD and TD groups.Conclusion: Dysfunction of DMN in the “triple-network model” is the core evidence for ASD with co-occurring ADHD.
format	article
author	Kai Wang Ke Li Xiaoyu Niu
author_facet	Kai Wang Ke Li Xiaoyu Niu
author_sort	Kai Wang
title	Altered Functional Connectivity in a Triple-Network Model in Autism With Co-occurring Attention Deficit Hyperactivity Disorder
title_short	Altered Functional Connectivity in a Triple-Network Model in Autism With Co-occurring Attention Deficit Hyperactivity Disorder
title_full	Altered Functional Connectivity in a Triple-Network Model in Autism With Co-occurring Attention Deficit Hyperactivity Disorder
title_fullStr	Altered Functional Connectivity in a Triple-Network Model in Autism With Co-occurring Attention Deficit Hyperactivity Disorder
title_full_unstemmed	Altered Functional Connectivity in a Triple-Network Model in Autism With Co-occurring Attention Deficit Hyperactivity Disorder
title_sort	altered functional connectivity in a triple-network model in autism with co-occurring attention deficit hyperactivity disorder
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ca619c13c39541ac9ce448aeace4981c
work_keys_str_mv	AT kaiwang alteredfunctionalconnectivityinatriplenetworkmodelinautismwithcooccurringattentiondeficithyperactivitydisorder AT keli alteredfunctionalconnectivityinatriplenetworkmodelinautismwithcooccurringattentiondeficithyperactivitydisorder AT xiaoyuniu alteredfunctionalconnectivityinatriplenetworkmodelinautismwithcooccurringattentiondeficithyperactivitydisorder
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Altered Functional Connectivity in a Triple-Network Model in Autism With Co-occurring Attention Deficit Hyperactivity Disorder

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