Tumor budding correlates with tumor invasiveness and predicts worse survival in pT1 non-muscle-invasive bladder cancer

Abstract Tumor budding is defined as a single cell or a cluster of up to 5 tumor cells at the invasion front. Due to the difficulty of identifying patients at high risk for pT1 non-muscle-invasive bladder cancer (NMIBC) and the difficulties in T1 substaging, tumor budding was evaluated as a potentia...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Markus Eckstein, Charlotte Kimmel, Johannes Bruendl, Florian Weber, Stefan Denzinger, Michael Gierth, Maximilian Burger, Arndt Hartmann, Wolfgang Otto, Johannes Breyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca635bbac05144efb1ac446a8f6dca4f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ca635bbac05144efb1ac446a8f6dca4f
record_format	dspace
spelling	oai:doaj.org-article:ca635bbac05144efb1ac446a8f6dca4f2021-12-02T19:12:31ZTumor budding correlates with tumor invasiveness and predicts worse survival in pT1 non-muscle-invasive bladder cancer10.1038/s41598-021-97500-32045-2322https://doaj.org/article/ca635bbac05144efb1ac446a8f6dca4f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97500-3https://doaj.org/toc/2045-2322Abstract Tumor budding is defined as a single cell or a cluster of up to 5 tumor cells at the invasion front. Due to the difficulty of identifying patients at high risk for pT1 non-muscle-invasive bladder cancer (NMIBC) and the difficulties in T1 substaging, tumor budding was evaluated as a potential alternative and prognostic parameter in these patients. Tumor budding as well as growth pattern, invasion pattern and lamina propria infiltration were retrospectively evaluated in transurethral resection of the bladder (TURB) specimens from 92 patients with stage pT1 NMIBC. The presence of tumor budding correlated with multifocal tumors (p = 0.003), discontinuous invasion pattern (p = 0.039), discohesive growth pattern (p < 0.001) and extensive lamina propria invasion (p < 0.001). In Kaplan–Meier analysis, tumor budding was associated with significantly worse RFS (p = 0.005), PFS (p = 0.017) and CSS (p = 0.002). In patients who received BCG instillation therapy (n = 65), the absence of tumor budding was associated with improved RFS (p = 0.012), PFS (p = 0.011) and CSS (p = 0.022), with none of the patients suffering from progression or dying from the disease. Tumor budding is associated with a more aggressive and invasive stage of pT1 NMIBC and a worse outcome. This easy-to-assess parameter could help stratify patients into BCG therapy or early cystectomy treatment groups.Markus EcksteinCharlotte KimmelJohannes BruendlFlorian WeberStefan DenzingerMichael GierthMaximilian BurgerArndt HartmannWolfgang OttoJohannes BreyerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Markus Eckstein Charlotte Kimmel Johannes Bruendl Florian Weber Stefan Denzinger Michael Gierth Maximilian Burger Arndt Hartmann Wolfgang Otto Johannes Breyer Tumor budding correlates with tumor invasiveness and predicts worse survival in pT1 non-muscle-invasive bladder cancer
description	Abstract Tumor budding is defined as a single cell or a cluster of up to 5 tumor cells at the invasion front. Due to the difficulty of identifying patients at high risk for pT1 non-muscle-invasive bladder cancer (NMIBC) and the difficulties in T1 substaging, tumor budding was evaluated as a potential alternative and prognostic parameter in these patients. Tumor budding as well as growth pattern, invasion pattern and lamina propria infiltration were retrospectively evaluated in transurethral resection of the bladder (TURB) specimens from 92 patients with stage pT1 NMIBC. The presence of tumor budding correlated with multifocal tumors (p = 0.003), discontinuous invasion pattern (p = 0.039), discohesive growth pattern (p < 0.001) and extensive lamina propria invasion (p < 0.001). In Kaplan–Meier analysis, tumor budding was associated with significantly worse RFS (p = 0.005), PFS (p = 0.017) and CSS (p = 0.002). In patients who received BCG instillation therapy (n = 65), the absence of tumor budding was associated with improved RFS (p = 0.012), PFS (p = 0.011) and CSS (p = 0.022), with none of the patients suffering from progression or dying from the disease. Tumor budding is associated with a more aggressive and invasive stage of pT1 NMIBC and a worse outcome. This easy-to-assess parameter could help stratify patients into BCG therapy or early cystectomy treatment groups.
format	article
author	Markus Eckstein Charlotte Kimmel Johannes Bruendl Florian Weber Stefan Denzinger Michael Gierth Maximilian Burger Arndt Hartmann Wolfgang Otto Johannes Breyer
author_facet	Markus Eckstein Charlotte Kimmel Johannes Bruendl Florian Weber Stefan Denzinger Michael Gierth Maximilian Burger Arndt Hartmann Wolfgang Otto Johannes Breyer
author_sort	Markus Eckstein
title	Tumor budding correlates with tumor invasiveness and predicts worse survival in pT1 non-muscle-invasive bladder cancer
title_short	Tumor budding correlates with tumor invasiveness and predicts worse survival in pT1 non-muscle-invasive bladder cancer
title_full	Tumor budding correlates with tumor invasiveness and predicts worse survival in pT1 non-muscle-invasive bladder cancer
title_fullStr	Tumor budding correlates with tumor invasiveness and predicts worse survival in pT1 non-muscle-invasive bladder cancer
title_full_unstemmed	Tumor budding correlates with tumor invasiveness and predicts worse survival in pT1 non-muscle-invasive bladder cancer
title_sort	tumor budding correlates with tumor invasiveness and predicts worse survival in pt1 non-muscle-invasive bladder cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ca635bbac05144efb1ac446a8f6dca4f
work_keys_str_mv	AT markuseckstein tumorbuddingcorrelateswithtumorinvasivenessandpredictsworsesurvivalinpt1nonmuscleinvasivebladdercancer AT charlottekimmel tumorbuddingcorrelateswithtumorinvasivenessandpredictsworsesurvivalinpt1nonmuscleinvasivebladdercancer AT johannesbruendl tumorbuddingcorrelateswithtumorinvasivenessandpredictsworsesurvivalinpt1nonmuscleinvasivebladdercancer AT florianweber tumorbuddingcorrelateswithtumorinvasivenessandpredictsworsesurvivalinpt1nonmuscleinvasivebladdercancer AT stefandenzinger tumorbuddingcorrelateswithtumorinvasivenessandpredictsworsesurvivalinpt1nonmuscleinvasivebladdercancer AT michaelgierth tumorbuddingcorrelateswithtumorinvasivenessandpredictsworsesurvivalinpt1nonmuscleinvasivebladdercancer AT maximilianburger tumorbuddingcorrelateswithtumorinvasivenessandpredictsworsesurvivalinpt1nonmuscleinvasivebladdercancer AT arndthartmann tumorbuddingcorrelateswithtumorinvasivenessandpredictsworsesurvivalinpt1nonmuscleinvasivebladdercancer AT wolfgangotto tumorbuddingcorrelateswithtumorinvasivenessandpredictsworsesurvivalinpt1nonmuscleinvasivebladdercancer AT johannesbreyer tumorbuddingcorrelateswithtumorinvasivenessandpredictsworsesurvivalinpt1nonmuscleinvasivebladdercancer
_version_	1718377063398768640

Tumor budding correlates with tumor invasiveness and predicts worse survival in pT1 non-muscle-invasive bladder cancer

Ejemplares similares