Inherited and Acquired Rhythm Disturbances in Sick Sinus Syndrome, Brugada Syndrome, and Atrial Fibrillation: Lessons from Preclinical Modeling

Rhythm disturbances are life-threatening cardiovascular diseases, accounting for many deaths annually worldwide. Abnormal electrical activity might arise in a structurally normal heart in response to specific triggers or as a consequence of cardiac tissue alterations, in both cases with catastrophic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Laura Iop, Sabino Iliceto, Giovanni Civieri, Francesco Tona
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cardiac conduction system rhythm disturbances preclinical modeling in vivo in vitro in silico Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ca6376652b5b47cb9117036a80768683
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ca6376652b5b47cb9117036a80768683
record_format	dspace
spelling	oai:doaj.org-article:ca6376652b5b47cb9117036a807686832021-11-25T17:12:21ZInherited and Acquired Rhythm Disturbances in Sick Sinus Syndrome, Brugada Syndrome, and Atrial Fibrillation: Lessons from Preclinical Modeling10.3390/cells101131752073-4409https://doaj.org/article/ca6376652b5b47cb9117036a807686832021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3175https://doaj.org/toc/2073-4409Rhythm disturbances are life-threatening cardiovascular diseases, accounting for many deaths annually worldwide. Abnormal electrical activity might arise in a structurally normal heart in response to specific triggers or as a consequence of cardiac tissue alterations, in both cases with catastrophic consequences on heart global functioning. Preclinical modeling by recapitulating human pathophysiology of rhythm disturbances is fundamental to increase the comprehension of these diseases and propose effective strategies for their prevention, diagnosis, and clinical management. In silico, in vivo, and in vitro models found variable application to dissect many congenital and acquired rhythm disturbances. In the copious list of rhythm disturbances, diseases of the conduction system, as sick sinus syndrome, Brugada syndrome, and atrial fibrillation, have found extensive preclinical modeling. In addition, the electrical remodeling as a result of other cardiovascular diseases has also been investigated in models of hypertrophic cardiomyopathy, cardiac fibrosis, as well as arrhythmias induced by other non-cardiac pathologies, stress, and drug cardiotoxicity. This review aims to offer a critical overview on the effective ability of in silico bioinformatic tools, in vivo animal studies, in vitro models to provide insights on human heart rhythm pathophysiology in case of sick sinus syndrome, Brugada syndrome, and atrial fibrillation and advance their safe and successful translation into the cardiology arena.Laura IopSabino IlicetoGiovanni CivieriFrancesco TonaMDPI AGarticlecardiac conduction systemrhythm disturbancespreclinical modelingin vivoin vitroin silicoBiology (General)QH301-705.5ENCells, Vol 10, Iss 3175, p 3175 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiac conduction system rhythm disturbances preclinical modeling in vivo in vitro in silico Biology (General) QH301-705.5
spellingShingle	cardiac conduction system rhythm disturbances preclinical modeling in vivo in vitro in silico Biology (General) QH301-705.5 Laura Iop Sabino Iliceto Giovanni Civieri Francesco Tona Inherited and Acquired Rhythm Disturbances in Sick Sinus Syndrome, Brugada Syndrome, and Atrial Fibrillation: Lessons from Preclinical Modeling
description	Rhythm disturbances are life-threatening cardiovascular diseases, accounting for many deaths annually worldwide. Abnormal electrical activity might arise in a structurally normal heart in response to specific triggers or as a consequence of cardiac tissue alterations, in both cases with catastrophic consequences on heart global functioning. Preclinical modeling by recapitulating human pathophysiology of rhythm disturbances is fundamental to increase the comprehension of these diseases and propose effective strategies for their prevention, diagnosis, and clinical management. In silico, in vivo, and in vitro models found variable application to dissect many congenital and acquired rhythm disturbances. In the copious list of rhythm disturbances, diseases of the conduction system, as sick sinus syndrome, Brugada syndrome, and atrial fibrillation, have found extensive preclinical modeling. In addition, the electrical remodeling as a result of other cardiovascular diseases has also been investigated in models of hypertrophic cardiomyopathy, cardiac fibrosis, as well as arrhythmias induced by other non-cardiac pathologies, stress, and drug cardiotoxicity. This review aims to offer a critical overview on the effective ability of in silico bioinformatic tools, in vivo animal studies, in vitro models to provide insights on human heart rhythm pathophysiology in case of sick sinus syndrome, Brugada syndrome, and atrial fibrillation and advance their safe and successful translation into the cardiology arena.
format	article
author	Laura Iop Sabino Iliceto Giovanni Civieri Francesco Tona
author_facet	Laura Iop Sabino Iliceto Giovanni Civieri Francesco Tona
author_sort	Laura Iop
title	Inherited and Acquired Rhythm Disturbances in Sick Sinus Syndrome, Brugada Syndrome, and Atrial Fibrillation: Lessons from Preclinical Modeling
title_short	Inherited and Acquired Rhythm Disturbances in Sick Sinus Syndrome, Brugada Syndrome, and Atrial Fibrillation: Lessons from Preclinical Modeling
title_full	Inherited and Acquired Rhythm Disturbances in Sick Sinus Syndrome, Brugada Syndrome, and Atrial Fibrillation: Lessons from Preclinical Modeling
title_fullStr	Inherited and Acquired Rhythm Disturbances in Sick Sinus Syndrome, Brugada Syndrome, and Atrial Fibrillation: Lessons from Preclinical Modeling
title_full_unstemmed	Inherited and Acquired Rhythm Disturbances in Sick Sinus Syndrome, Brugada Syndrome, and Atrial Fibrillation: Lessons from Preclinical Modeling
title_sort	inherited and acquired rhythm disturbances in sick sinus syndrome, brugada syndrome, and atrial fibrillation: lessons from preclinical modeling
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ca6376652b5b47cb9117036a80768683
work_keys_str_mv	AT lauraiop inheritedandacquiredrhythmdisturbancesinsicksinussyndromebrugadasyndromeandatrialfibrillationlessonsfrompreclinicalmodeling AT sabinoiliceto inheritedandacquiredrhythmdisturbancesinsicksinussyndromebrugadasyndromeandatrialfibrillationlessonsfrompreclinicalmodeling AT giovannicivieri inheritedandacquiredrhythmdisturbancesinsicksinussyndromebrugadasyndromeandatrialfibrillationlessonsfrompreclinicalmodeling AT francescotona inheritedandacquiredrhythmdisturbancesinsicksinussyndromebrugadasyndromeandatrialfibrillationlessonsfrompreclinicalmodeling
_version_	1718412678631784448

Inherited and Acquired Rhythm Disturbances in Sick Sinus Syndrome, Brugada Syndrome, and Atrial Fibrillation: Lessons from Preclinical Modeling

Ejemplares similares