Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives

Anesthetics are extensively used during cancer surgeries. The progression of cancer can be influenced by perioperative events such as exposure to general or local anesthesia. However, whether they inhibit cancer or act as a causative factor for metastasis and exert deleterious effects on cancer grow...

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Autores principales:	Peyman Tabnak, Soroush Masrouri, Kiarash Roustai Geraylow, Mahtab Zarei, Zanyar Haji Esmailpoor
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	miRNA lncRNA circRNA General anesthetic Volatile anesthetic Local anesthetic Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ca67d3ad5d2a4c028cf0f1248da5c1a2
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spelling	oai:doaj.org-article:ca67d3ad5d2a4c028cf0f1248da5c1a22021-11-14T04:29:28ZTargeting miRNAs with anesthetics in cancer: Current understanding and future perspectives0753-332210.1016/j.biopha.2021.112309https://doaj.org/article/ca67d3ad5d2a4c028cf0f1248da5c1a22021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010933https://doaj.org/toc/0753-3322Anesthetics are extensively used during cancer surgeries. The progression of cancer can be influenced by perioperative events such as exposure to general or local anesthesia. However, whether they inhibit cancer or act as a causative factor for metastasis and exert deleterious effects on cancer growth differs based on the type of cancer and the therapy administration. Recent experimental data suggested that many of the most commonly used anesthetics in surgical oncology, whether general or local agents, can alter gene expression and cause epigenetic changes via modulating miRNAs. miRNAs are single-stranded non-coding RNAs that regulate gene expression at various levels, and their dysregulation contributes to the pathogenesis of cancers. However, anesthetics via regulating miRNAs can concurrently target several effectors of cellular signaling pathways involved in cell differentiation, proliferation, and viability. This review summarized the current research about the effects of different anesthetics in regulating cancer, with a particular emphasis on the role of miRNAs. A significant number of studies conducted in this area of research illuminate the effects of anesthetics on the regulation of miRNA expression; therefore, we hope that a thorough understanding of the underlying mechanisms involved in the regulation of miRNA in the context of anesthesia-induced cancer regulation could help to define optimal anesthetic regimens and provide better perspectives for further studies.Peyman TabnakSoroush MasrouriKiarash Roustai GeraylowMahtab ZareiZanyar Haji EsmailpoorElsevierarticlemiRNAlncRNAcircRNAGeneral anestheticVolatile anestheticLocal anestheticTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112309- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	miRNA lncRNA circRNA General anesthetic Volatile anesthetic Local anesthetic Therapeutics. Pharmacology RM1-950
spellingShingle	miRNA lncRNA circRNA General anesthetic Volatile anesthetic Local anesthetic Therapeutics. Pharmacology RM1-950 Peyman Tabnak Soroush Masrouri Kiarash Roustai Geraylow Mahtab Zarei Zanyar Haji Esmailpoor Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives
description	Anesthetics are extensively used during cancer surgeries. The progression of cancer can be influenced by perioperative events such as exposure to general or local anesthesia. However, whether they inhibit cancer or act as a causative factor for metastasis and exert deleterious effects on cancer growth differs based on the type of cancer and the therapy administration. Recent experimental data suggested that many of the most commonly used anesthetics in surgical oncology, whether general or local agents, can alter gene expression and cause epigenetic changes via modulating miRNAs. miRNAs are single-stranded non-coding RNAs that regulate gene expression at various levels, and their dysregulation contributes to the pathogenesis of cancers. However, anesthetics via regulating miRNAs can concurrently target several effectors of cellular signaling pathways involved in cell differentiation, proliferation, and viability. This review summarized the current research about the effects of different anesthetics in regulating cancer, with a particular emphasis on the role of miRNAs. A significant number of studies conducted in this area of research illuminate the effects of anesthetics on the regulation of miRNA expression; therefore, we hope that a thorough understanding of the underlying mechanisms involved in the regulation of miRNA in the context of anesthesia-induced cancer regulation could help to define optimal anesthetic regimens and provide better perspectives for further studies.
format	article
author	Peyman Tabnak Soroush Masrouri Kiarash Roustai Geraylow Mahtab Zarei Zanyar Haji Esmailpoor
author_facet	Peyman Tabnak Soroush Masrouri Kiarash Roustai Geraylow Mahtab Zarei Zanyar Haji Esmailpoor
author_sort	Peyman Tabnak
title	Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives
title_short	Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives
title_full	Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives
title_fullStr	Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives
title_full_unstemmed	Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives
title_sort	targeting mirnas with anesthetics in cancer: current understanding and future perspectives
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ca67d3ad5d2a4c028cf0f1248da5c1a2
work_keys_str_mv	AT peymantabnak targetingmirnaswithanestheticsincancercurrentunderstandingandfutureperspectives AT soroushmasrouri targetingmirnaswithanestheticsincancercurrentunderstandingandfutureperspectives AT kiarashroustaigeraylow targetingmirnaswithanestheticsincancercurrentunderstandingandfutureperspectives AT mahtabzarei targetingmirnaswithanestheticsincancercurrentunderstandingandfutureperspectives AT zanyarhajiesmailpoor targetingmirnaswithanestheticsincancercurrentunderstandingandfutureperspectives
_version_	1718430042228260864

Targeting miRNAs with anesthetics in cancer: Current understanding and future perspectives

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