Biosynthesis of Smaller-Sized Platinum Nanoparticles Using the Leaf Extract of <i>Combretum erythrophyllum</i> and Its Antibacterial Activities

Nanobiotechnology is a promising field in the development of safe antibiotics to combat the increasing trend of antibiotic resistance. Nature is a vast reservoir for green materials used in the synthesis of non-toxic and environmentally friendly nano-antibiotics. We present for the first time a faci...

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Autores principales:	Olufunto T. Fanoro, Sundararajan Parani, Rodney Maluleke, Thabang C. Lebepe, Rajendran J. Varghese, Nande Mgedle, Vuyo Mavumengwana, Oluwatobi S. Oluwafemi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Combretum erythrophyllum</i> platinum nanoparticles green synthesis antibacterial <i>Klebsiella oxytoca</i> <i>Klebsiella aerogenes</i> Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ca6a9c2116e642588e1c9988b0d82535
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spelling	oai:doaj.org-article:ca6a9c2116e642588e1c9988b0d825352021-11-25T16:21:49ZBiosynthesis of Smaller-Sized Platinum Nanoparticles Using the Leaf Extract of <i>Combretum erythrophyllum</i> and Its Antibacterial Activities10.3390/antibiotics101112752079-6382https://doaj.org/article/ca6a9c2116e642588e1c9988b0d825352021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1275https://doaj.org/toc/2079-6382Nanobiotechnology is a promising field in the development of safe antibiotics to combat the increasing trend of antibiotic resistance. Nature is a vast reservoir for green materials used in the synthesis of non-toxic and environmentally friendly nano-antibiotics. We present for the first time a facile, green, cost-effective, plant-mediated synthesis of platinum nanoparticles (PtNPs) using the extract of <i>Combretum erythrophyllum</i> (CE) plant leaves. The extract of CE served as both a bio-reductant and a stabilizing agent. The as-synthesized PtNPs were characterized using ultraviolet-visible (UV–Vis) absorption spectroscopy, high-resolution transmission electron microscopy (HR-TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and dynamic light scattering (DLS) techniques. The HR-TEM image confirmed that the PtNPs are ultrasmall, spherical, and well dispersed with an average particle diameter of 1.04 ± 0.26 nm. The PtNPs showed strong antibacterial activities against pathogenic Gram-positive <i>Staphylococcus epidermidis</i> (ATCC 14990) at a minimum inhibitory concentration (MIC) of 3.125 µg/mL and Gram-negative <i>Klebsiella oxytoca</i> (ATCC 8724) and <i>Klebsiella aerogenes</i> (ATCC 27853) at an MIC value of 1.56 µg/mL. The CE-stabilized PtNPs was mostly effective in <i>Klebsiella</i> species that are causative organisms in nosocomial infections.Olufunto T. FanoroSundararajan ParaniRodney MalulekeThabang C. LebepeRajendran J. VargheseNande MgedleVuyo MavumengwanaOluwatobi S. OluwafemiMDPI AGarticle<i>Combretum erythrophyllum</i>platinum nanoparticlesgreen synthesisantibacterial<i>Klebsiella oxytoca</i><i>Klebsiella aerogenes</i>Therapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1275, p 1275 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Combretum erythrophyllum</i> platinum nanoparticles green synthesis antibacterial <i>Klebsiella oxytoca</i> <i>Klebsiella aerogenes</i> Therapeutics. Pharmacology RM1-950
spellingShingle	<i>Combretum erythrophyllum</i> platinum nanoparticles green synthesis antibacterial <i>Klebsiella oxytoca</i> <i>Klebsiella aerogenes</i> Therapeutics. Pharmacology RM1-950 Olufunto T. Fanoro Sundararajan Parani Rodney Maluleke Thabang C. Lebepe Rajendran J. Varghese Nande Mgedle Vuyo Mavumengwana Oluwatobi S. Oluwafemi Biosynthesis of Smaller-Sized Platinum Nanoparticles Using the Leaf Extract of <i>Combretum erythrophyllum</i> and Its Antibacterial Activities
description	Nanobiotechnology is a promising field in the development of safe antibiotics to combat the increasing trend of antibiotic resistance. Nature is a vast reservoir for green materials used in the synthesis of non-toxic and environmentally friendly nano-antibiotics. We present for the first time a facile, green, cost-effective, plant-mediated synthesis of platinum nanoparticles (PtNPs) using the extract of <i>Combretum erythrophyllum</i> (CE) plant leaves. The extract of CE served as both a bio-reductant and a stabilizing agent. The as-synthesized PtNPs were characterized using ultraviolet-visible (UV–Vis) absorption spectroscopy, high-resolution transmission electron microscopy (HR-TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and dynamic light scattering (DLS) techniques. The HR-TEM image confirmed that the PtNPs are ultrasmall, spherical, and well dispersed with an average particle diameter of 1.04 ± 0.26 nm. The PtNPs showed strong antibacterial activities against pathogenic Gram-positive <i>Staphylococcus epidermidis</i> (ATCC 14990) at a minimum inhibitory concentration (MIC) of 3.125 µg/mL and Gram-negative <i>Klebsiella oxytoca</i> (ATCC 8724) and <i>Klebsiella aerogenes</i> (ATCC 27853) at an MIC value of 1.56 µg/mL. The CE-stabilized PtNPs was mostly effective in <i>Klebsiella</i> species that are causative organisms in nosocomial infections.
format	article
author	Olufunto T. Fanoro Sundararajan Parani Rodney Maluleke Thabang C. Lebepe Rajendran J. Varghese Nande Mgedle Vuyo Mavumengwana Oluwatobi S. Oluwafemi
author_facet	Olufunto T. Fanoro Sundararajan Parani Rodney Maluleke Thabang C. Lebepe Rajendran J. Varghese Nande Mgedle Vuyo Mavumengwana Oluwatobi S. Oluwafemi
author_sort	Olufunto T. Fanoro
title	Biosynthesis of Smaller-Sized Platinum Nanoparticles Using the Leaf Extract of <i>Combretum erythrophyllum</i> and Its Antibacterial Activities
title_short	Biosynthesis of Smaller-Sized Platinum Nanoparticles Using the Leaf Extract of <i>Combretum erythrophyllum</i> and Its Antibacterial Activities
title_full	Biosynthesis of Smaller-Sized Platinum Nanoparticles Using the Leaf Extract of <i>Combretum erythrophyllum</i> and Its Antibacterial Activities
title_fullStr	Biosynthesis of Smaller-Sized Platinum Nanoparticles Using the Leaf Extract of <i>Combretum erythrophyllum</i> and Its Antibacterial Activities
title_full_unstemmed	Biosynthesis of Smaller-Sized Platinum Nanoparticles Using the Leaf Extract of <i>Combretum erythrophyllum</i> and Its Antibacterial Activities
title_sort	biosynthesis of smaller-sized platinum nanoparticles using the leaf extract of <i>combretum erythrophyllum</i> and its antibacterial activities
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ca6a9c2116e642588e1c9988b0d82535
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Biosynthesis of Smaller-Sized Platinum Nanoparticles Using the Leaf Extract of <i>Combretum erythrophyllum</i> and Its Antibacterial Activities

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