Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate

Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate

Abstract Chronic myelomonocytic leukemia (CMML) is an entity of myelodysplastic syndrome/myeloproliferative neoplasm. Although CMML can be cured with allogeneic stem cell transplantation, its prognosis is generally very poor due to the limited efficacy of chemotherapy and to the patient’s age, which...

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Bibliographic Details
Main Authors: Kazuki Taoka, Shunya Arai, Keisuke Kataoka, Masataka Hosoi, Masashi Miyauchi, Sho Yamazaki, Akira Honda, Wei Aixinjueluo, Takashi Kobayashi, Keiki Kumano, Akihide Yoshimi, Makoto Otsu, Akira Niwa, Tatsutoshi Nakahata, Hiromitsu Nakauchi, Mineo Kurokawa
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Chronic Myelomonocytic Leukemia (CMML)
Clodronate Liposomes
Drug Testing Systems
Teratoma
Hematopoietic Progenitor Cells (HPCs)
Medicine
R
Science
Q
Online Access:https://doaj.org/article/ca6c14c5e42546afa52dabe821a5a19d
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