Neurogenesis in the aging brain

Veronica Galvan, Kunlin JinBuck Institute for Age Research, 8001 Redwood Blvd. Novato, CA, USAAbstract: Neurogenesis, or the birth of new neural cells, was thought to occur only in the developing nervous system and a fixed neuronal population in the adult brain was believed to be necessary to mainta...

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Autores principales:	Veronica Galvan, Kunlin Jin
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/ca6cb7373dd04af1b6deed71e1582f43
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spelling	oai:doaj.org-article:ca6cb7373dd04af1b6deed71e1582f432021-12-02T00:27:35ZNeurogenesis in the aging brain1178-1998https://doaj.org/article/ca6cb7373dd04af1b6deed71e1582f432008-01-01T00:00:00Zhttps://www.dovepress.com/neurogenesis-in-the-aging-brain-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Veronica Galvan, Kunlin JinBuck Institute for Age Research, 8001 Redwood Blvd. Novato, CA, USAAbstract: Neurogenesis, or the birth of new neural cells, was thought to occur only in the developing nervous system and a fixed neuronal population in the adult brain was believed to be necessary to maintain the functional stability of adult brain circuitry. However, recent studies have demonstrated that neurogenesis does indeed continue into and throughout adult life in discrete regions of the central nervous systems (CNS) of all mammals, including humans. Although neurogenesis may contribute to the ability of the adult brain to function normally and be induced in response to cerebral diseases for self-repair, this nevertheless declines with advancing age. Understanding the basic biology of neural stem cells and the molecular and cellular regulation mechanisms of neurogenesis in young and aged brain will allow us to modulate cell replacement processes in the adult brain for the maintenance of healthy brain tissues and for repair of disease states in the elderly.Keywords: neurogenesis, aging, brain, neural stem cells, subgranular zone, subventricular zoneVeronica GalvanKunlin JinDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 2, Pp 605-610 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Veronica Galvan Kunlin Jin Neurogenesis in the aging brain
description	Veronica Galvan, Kunlin JinBuck Institute for Age Research, 8001 Redwood Blvd. Novato, CA, USAAbstract: Neurogenesis, or the birth of new neural cells, was thought to occur only in the developing nervous system and a fixed neuronal population in the adult brain was believed to be necessary to maintain the functional stability of adult brain circuitry. However, recent studies have demonstrated that neurogenesis does indeed continue into and throughout adult life in discrete regions of the central nervous systems (CNS) of all mammals, including humans. Although neurogenesis may contribute to the ability of the adult brain to function normally and be induced in response to cerebral diseases for self-repair, this nevertheless declines with advancing age. Understanding the basic biology of neural stem cells and the molecular and cellular regulation mechanisms of neurogenesis in young and aged brain will allow us to modulate cell replacement processes in the adult brain for the maintenance of healthy brain tissues and for repair of disease states in the elderly.Keywords: neurogenesis, aging, brain, neural stem cells, subgranular zone, subventricular zone
format	article
author	Veronica Galvan Kunlin Jin
author_facet	Veronica Galvan Kunlin Jin
author_sort	Veronica Galvan
title	Neurogenesis in the aging brain
title_short	Neurogenesis in the aging brain
title_full	Neurogenesis in the aging brain
title_fullStr	Neurogenesis in the aging brain
title_full_unstemmed	Neurogenesis in the aging brain
title_sort	neurogenesis in the aging brain
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/ca6cb7373dd04af1b6deed71e1582f43
work_keys_str_mv	AT veronicagalvan neurogenesisintheagingbrain AT kunlinjin neurogenesisintheagingbrain
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Neurogenesis in the aging brain

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