Propofol versus Midazolam in Sedation for Upper Gastrointestinal Endoscopy

Background: Upper gastrointestinal endoscopy [either diagnostic or therapeutic] is widely practiced under conscious sedation. However, the standard sedative agent or drug combination is not yet well established.Aim of the work: Comparison between propofol-fentanyl and midazolam-fentanyl for sedation...

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Autores principales:	Foad Mohamed, Yosry Kandil
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2019
Materias:	endoscopy sedation fentanyl propofol midazolam gastrointestinal Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ca6dedb40a9c4b10911ef9c7ae119c42
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spelling	oai:doaj.org-article:ca6dedb40a9c4b10911ef9c7ae119c422021-12-02T13:53:21ZPropofol versus Midazolam in Sedation for Upper Gastrointestinal Endoscopy2636-41742682-378010.21608/ijma.2019.18082.1037https://doaj.org/article/ca6dedb40a9c4b10911ef9c7ae119c422019-10-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_54056_da7a5afaa5abb1ed7fc89c1cd4ccff3a.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Upper gastrointestinal endoscopy [either diagnostic or therapeutic] is widely practiced under conscious sedation. However, the standard sedative agent or drug combination is not yet well established.Aim of the work: Comparison between propofol-fentanyl and midazolam-fentanyl for sedation in upper gastrointestinal endoscopy.Patients and methods: Sixty patients from those scheduled to undergo upper gastrointestinal endoscopy at the Gastrointestinal Endoscopy Unit were included. Patients were divided into two equal groups: propofol-fentanyl and midazolam fentanyl. The Anesthetist scheduled to perform the procedures was oriented by the drug, while patients did not know the sedating drug. Prior to the procedure, a clinical history and physical examination was carried out, and throughout the procedure the patient was monitored for blood pressure, heart rate, respiratory rate, and oxygen saturation. Both groups were compared regarding time to recovery, patient satisfaction, physician satisfaction and adverse events.Results: Recovery time was significantly shorter, patient and physician satisfaction scores were significantly higher among propofol group. On the other side, systolic blood pressure was significantly lower in propofol group at midpoint and recovery times, while oxygen saturation was significantly reduced in midazolam group at intermediate point of the procedure. Finally, hypoxia was significantly higher among midazolam group [reported in 20.0%], versus [none] in propofol group. No other adverse events were encountered.Conclusion: Propofol is better sedative than midazolam for upper gastrointestinal endoscopy. Thus, it should be used as a first-line drug in sedation in our endoscopy units.Foad MohamedYosry KandilAl-Azhar University, Faculty of Medicine (Damietta)articleendoscopysedationfentanylpropofolmidazolamgastrointestinalMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 1, Iss 2, Pp 138-143 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	endoscopy sedation fentanyl propofol midazolam gastrointestinal Medicine (General) R5-920
spellingShingle	endoscopy sedation fentanyl propofol midazolam gastrointestinal Medicine (General) R5-920 Foad Mohamed Yosry Kandil Propofol versus Midazolam in Sedation for Upper Gastrointestinal Endoscopy
description	Background: Upper gastrointestinal endoscopy [either diagnostic or therapeutic] is widely practiced under conscious sedation. However, the standard sedative agent or drug combination is not yet well established.Aim of the work: Comparison between propofol-fentanyl and midazolam-fentanyl for sedation in upper gastrointestinal endoscopy.Patients and methods: Sixty patients from those scheduled to undergo upper gastrointestinal endoscopy at the Gastrointestinal Endoscopy Unit were included. Patients were divided into two equal groups: propofol-fentanyl and midazolam fentanyl. The Anesthetist scheduled to perform the procedures was oriented by the drug, while patients did not know the sedating drug. Prior to the procedure, a clinical history and physical examination was carried out, and throughout the procedure the patient was monitored for blood pressure, heart rate, respiratory rate, and oxygen saturation. Both groups were compared regarding time to recovery, patient satisfaction, physician satisfaction and adverse events.Results: Recovery time was significantly shorter, patient and physician satisfaction scores were significantly higher among propofol group. On the other side, systolic blood pressure was significantly lower in propofol group at midpoint and recovery times, while oxygen saturation was significantly reduced in midazolam group at intermediate point of the procedure. Finally, hypoxia was significantly higher among midazolam group [reported in 20.0%], versus [none] in propofol group. No other adverse events were encountered.Conclusion: Propofol is better sedative than midazolam for upper gastrointestinal endoscopy. Thus, it should be used as a first-line drug in sedation in our endoscopy units.
format	article
author	Foad Mohamed Yosry Kandil
author_facet	Foad Mohamed Yosry Kandil
author_sort	Foad Mohamed
title	Propofol versus Midazolam in Sedation for Upper Gastrointestinal Endoscopy
title_short	Propofol versus Midazolam in Sedation for Upper Gastrointestinal Endoscopy
title_full	Propofol versus Midazolam in Sedation for Upper Gastrointestinal Endoscopy
title_fullStr	Propofol versus Midazolam in Sedation for Upper Gastrointestinal Endoscopy
title_full_unstemmed	Propofol versus Midazolam in Sedation for Upper Gastrointestinal Endoscopy
title_sort	propofol versus midazolam in sedation for upper gastrointestinal endoscopy
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2019
url	https://doaj.org/article/ca6dedb40a9c4b10911ef9c7ae119c42
work_keys_str_mv	AT foadmohamed propofolversusmidazolaminsedationforuppergastrointestinalendoscopy AT yosrykandil propofolversusmidazolaminsedationforuppergastrointestinalendoscopy
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Propofol versus Midazolam in Sedation for Upper Gastrointestinal Endoscopy

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