Evolution of Drug-resistant Acinetobacter baumannii After DCD Renal Transplantation
Abstract Infection after renal transplantation remains a major cause of morbidity and death, especially infection from the extensively drug-resistant bacteria, A. baumannii. A total of fourteen A. baumannii isolates were isolated from the donors’ preserved fluid from DCD (donation after cardiac deat...
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Nature Portfolio
2017
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oai:doaj.org-article:ca6f25afad514072824927dff218f3282021-12-02T16:07:01ZEvolution of Drug-resistant Acinetobacter baumannii After DCD Renal Transplantation10.1038/s41598-017-01683-72045-2322https://doaj.org/article/ca6f25afad514072824927dff218f3282017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01683-7https://doaj.org/toc/2045-2322Abstract Infection after renal transplantation remains a major cause of morbidity and death, especially infection from the extensively drug-resistant bacteria, A. baumannii. A total of fourteen A. baumannii isolates were isolated from the donors’ preserved fluid from DCD (donation after cardiac death) renal transplantation and four isolates in the recipients’ draining liquid at the Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, from March 2013 to November 2014. An outbreak of A. baumannii emerging after DCD renal transplantation was tracked to understand the transmission of the pathogen. PFGE displayed similar DNA patterns between isolates from the same hospital. Antimicrobial susceptibility tests against thirteen antimicrobial agents were determined using the K-B diffusion method and eTest. Whole-genome sequencing was applied to investigate the genetic relationship of the isolates. With the clinical data and research results, we concluded that the A. baumannii isolates 3R1 and 3R2 was probably transmitted from the donor who acquired the bacteria during his stay in the ICU, while isolate 4R1 was transmitted from 3R1 and 3R2 via medical manipulation. This study demonstrated the value of integration of clinical profiles with molecular methods in outbreak investigation and their importance in controlling infection and preventing serious complications after DCD transplantation.Hong JiangLuxi CaoLihui QuTingting QuGuangjun LiuRending WangBingjue LiYuchen WangChaoqun YingMiao ChenYingying LuShi FengYonghong XiaoJunwen WangJianyong WuJianghua ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) |
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Medicine R Science Q |
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Medicine R Science Q Hong Jiang Luxi Cao Lihui Qu Tingting Qu Guangjun Liu Rending Wang Bingjue Li Yuchen Wang Chaoqun Ying Miao Chen Yingying Lu Shi Feng Yonghong Xiao Junwen Wang Jianyong Wu Jianghua Chen Evolution of Drug-resistant Acinetobacter baumannii After DCD Renal Transplantation |
| description |
Abstract Infection after renal transplantation remains a major cause of morbidity and death, especially infection from the extensively drug-resistant bacteria, A. baumannii. A total of fourteen A. baumannii isolates were isolated from the donors’ preserved fluid from DCD (donation after cardiac death) renal transplantation and four isolates in the recipients’ draining liquid at the Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, from March 2013 to November 2014. An outbreak of A. baumannii emerging after DCD renal transplantation was tracked to understand the transmission of the pathogen. PFGE displayed similar DNA patterns between isolates from the same hospital. Antimicrobial susceptibility tests against thirteen antimicrobial agents were determined using the K-B diffusion method and eTest. Whole-genome sequencing was applied to investigate the genetic relationship of the isolates. With the clinical data and research results, we concluded that the A. baumannii isolates 3R1 and 3R2 was probably transmitted from the donor who acquired the bacteria during his stay in the ICU, while isolate 4R1 was transmitted from 3R1 and 3R2 via medical manipulation. This study demonstrated the value of integration of clinical profiles with molecular methods in outbreak investigation and their importance in controlling infection and preventing serious complications after DCD transplantation. |
| format |
article |
| author |
Hong Jiang Luxi Cao Lihui Qu Tingting Qu Guangjun Liu Rending Wang Bingjue Li Yuchen Wang Chaoqun Ying Miao Chen Yingying Lu Shi Feng Yonghong Xiao Junwen Wang Jianyong Wu Jianghua Chen |
| author_facet |
Hong Jiang Luxi Cao Lihui Qu Tingting Qu Guangjun Liu Rending Wang Bingjue Li Yuchen Wang Chaoqun Ying Miao Chen Yingying Lu Shi Feng Yonghong Xiao Junwen Wang Jianyong Wu Jianghua Chen |
| author_sort |
Hong Jiang |
| title |
Evolution of Drug-resistant Acinetobacter baumannii After DCD Renal Transplantation |
| title_short |
Evolution of Drug-resistant Acinetobacter baumannii After DCD Renal Transplantation |
| title_full |
Evolution of Drug-resistant Acinetobacter baumannii After DCD Renal Transplantation |
| title_fullStr |
Evolution of Drug-resistant Acinetobacter baumannii After DCD Renal Transplantation |
| title_full_unstemmed |
Evolution of Drug-resistant Acinetobacter baumannii After DCD Renal Transplantation |
| title_sort |
evolution of drug-resistant acinetobacter baumannii after dcd renal transplantation |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/ca6f25afad514072824927dff218f328 |
| work_keys_str_mv |
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1718384805138137088 |