Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

Lipid droplets are organelles that regulate lipid metabolism but if organellar contacts play a role during lipolysis is unclear. Here, the authors show that peroxisomes and peroxisomal protein PEX5 play pivotal roles in the spatial and temporal regulation of fasting-induced lipolysis by translocatin...

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Autores principales: Jinuk Kong, Yul Ji, Yong Geun Jeon, Ji Seul Han, Kyung Hee Han, Jung Hyun Lee, Gung Lee, Hagoon Jang, Sung Sik Choe, Myriam Baes, Jae Bum Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/ca6fe38e928249d98547a91aacc29c51
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spelling oai:doaj.org-article:ca6fe38e928249d98547a91aacc29c512021-12-02T16:49:28ZSpatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX510.1038/s41467-019-14176-02041-1723https://doaj.org/article/ca6fe38e928249d98547a91aacc29c512020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14176-0https://doaj.org/toc/2041-1723Lipid droplets are organelles that regulate lipid metabolism but if organellar contacts play a role during lipolysis is unclear. Here, the authors show that peroxisomes and peroxisomal protein PEX5 play pivotal roles in the spatial and temporal regulation of fasting-induced lipolysis by translocating ATGL onto lipid dropletsJinuk KongYul JiYong Geun JeonJi Seul HanKyung Hee HanJung Hyun LeeGung LeeHagoon JangSung Sik ChoeMyriam BaesJae Bum KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jinuk Kong
Yul Ji
Yong Geun Jeon
Ji Seul Han
Kyung Hee Han
Jung Hyun Lee
Gung Lee
Hagoon Jang
Sung Sik Choe
Myriam Baes
Jae Bum Kim
Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5
description Lipid droplets are organelles that regulate lipid metabolism but if organellar contacts play a role during lipolysis is unclear. Here, the authors show that peroxisomes and peroxisomal protein PEX5 play pivotal roles in the spatial and temporal regulation of fasting-induced lipolysis by translocating ATGL onto lipid droplets
format article
author Jinuk Kong
Yul Ji
Yong Geun Jeon
Ji Seul Han
Kyung Hee Han
Jung Hyun Lee
Gung Lee
Hagoon Jang
Sung Sik Choe
Myriam Baes
Jae Bum Kim
author_facet Jinuk Kong
Yul Ji
Yong Geun Jeon
Ji Seul Han
Kyung Hee Han
Jung Hyun Lee
Gung Lee
Hagoon Jang
Sung Sik Choe
Myriam Baes
Jae Bum Kim
author_sort Jinuk Kong
title Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5
title_short Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5
title_full Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5
title_fullStr Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5
title_full_unstemmed Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5
title_sort spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via pex5
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/ca6fe38e928249d98547a91aacc29c51
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AT yulji spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT yonggeunjeon spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT jiseulhan spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT kyungheehan spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
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AT gunglee spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT hagoonjang spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT sungsikchoe spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT myriambaes spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
AT jaebumkim spatiotemporalcontactbetweenperoxisomesandlipiddropletsregulatesfastinginducedlipolysisviapex5
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