Ellipsoid Zone and External Limiting Membrane-Related Parameters on Spectral Domain-Optical Coherence Tomography and Their Relationships With Visual Prognosis After Successful Macular Hole Surgery

Purpose: To compare structural diameters of the ellipsoid zone (EZ) and external limiting membrane (ELM) bands on spectral domain-optical coherence tomography (SD-OCT) images between vision-improved (group A) and vision-unimproved (group B) patients, and investigate the connection between these para...

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Autores principales:	Jiarui Yang, Huaqin Xia, Yushi Liu, Xinglin Wang, Hao Yuan, Qingyi Hou, Yimeng Ge, Yi Ding, Yuexin Wang, Changguan Wang, Xuemin Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	idiopathic macular hole optical coherence tomography (OCT) ellipsoid zone (EZ) external limiting membrane visual prognosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ca7103ed9ba847e687b08c245822864a
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spelling	oai:doaj.org-article:ca7103ed9ba847e687b08c245822864a2021-11-10T07:01:05ZEllipsoid Zone and External Limiting Membrane-Related Parameters on Spectral Domain-Optical Coherence Tomography and Their Relationships With Visual Prognosis After Successful Macular Hole Surgery2296-858X10.3389/fmed.2021.779602https://doaj.org/article/ca7103ed9ba847e687b08c245822864a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.779602/fullhttps://doaj.org/toc/2296-858XPurpose: To compare structural diameters of the ellipsoid zone (EZ) and external limiting membrane (ELM) bands on spectral domain-optical coherence tomography (SD-OCT) images between vision-improved (group A) and vision-unimproved (group B) patients, and investigate the connection between these parameters and visual prognosis.Materials and Methods: Forty-five eyes of 43 patients with idiopathic full-thickness macular hole closed after vitrectomy were retrospectively reviewed. Best-corrected visual acuity (BCVA) and SD-OCT were conducted preoperatively and at 1 week, 1 month and 6 months postoperatively. Structural and functional parameters were then measured using ImageJ software.Results: Among structural and functional parameters, the relative reflectivity of EZ and the ratio of continuous ELM and EZ in group A were significantly higher than in group B from the 1-month postoperative visit. At the 6-month follow-up, the diameter of EZ disruption in group A was significantly smaller than in group B, and the relative reflectivity of ELM/EZ was significantly higher than group B. At 6-months, BCVA was statistically significantly correlated with baseline BCVA, basal diameter (BD), macular hole index (MHI), and diameter of ELM/EZ disruption. Change in BCVA from baseline was found to be significantly correlated with axial length and diameter hole index (DHI).Conclusions: Postoperative BCVA outcome was significantly correlated with integrity, thickness and reflectivity of the EZ band. Patients with smaller diameter of EZ disruption and higher reflectivity of EZ band tended to have better visual outcomes. Given that the EZ band reflects the recovery of mitochondria in photoreceptors, it is a promising parameter for their functional evaluation.Jiarui YangHuaqin XiaYushi LiuXinglin WangHao YuanQingyi HouYimeng GeYi DingYuexin WangChangguan WangChangguan WangXuemin LiXuemin LiFrontiers Media S.A.articleidiopathic macular holeoptical coherence tomography (OCT)ellipsoid zone (EZ)external limiting membranevisual prognosisMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	idiopathic macular hole optical coherence tomography (OCT) ellipsoid zone (EZ) external limiting membrane visual prognosis Medicine (General) R5-920
spellingShingle	idiopathic macular hole optical coherence tomography (OCT) ellipsoid zone (EZ) external limiting membrane visual prognosis Medicine (General) R5-920 Jiarui Yang Huaqin Xia Yushi Liu Xinglin Wang Hao Yuan Qingyi Hou Yimeng Ge Yi Ding Yuexin Wang Changguan Wang Changguan Wang Xuemin Li Xuemin Li Ellipsoid Zone and External Limiting Membrane-Related Parameters on Spectral Domain-Optical Coherence Tomography and Their Relationships With Visual Prognosis After Successful Macular Hole Surgery
description	Purpose: To compare structural diameters of the ellipsoid zone (EZ) and external limiting membrane (ELM) bands on spectral domain-optical coherence tomography (SD-OCT) images between vision-improved (group A) and vision-unimproved (group B) patients, and investigate the connection between these parameters and visual prognosis.Materials and Methods: Forty-five eyes of 43 patients with idiopathic full-thickness macular hole closed after vitrectomy were retrospectively reviewed. Best-corrected visual acuity (BCVA) and SD-OCT were conducted preoperatively and at 1 week, 1 month and 6 months postoperatively. Structural and functional parameters were then measured using ImageJ software.Results: Among structural and functional parameters, the relative reflectivity of EZ and the ratio of continuous ELM and EZ in group A were significantly higher than in group B from the 1-month postoperative visit. At the 6-month follow-up, the diameter of EZ disruption in group A was significantly smaller than in group B, and the relative reflectivity of ELM/EZ was significantly higher than group B. At 6-months, BCVA was statistically significantly correlated with baseline BCVA, basal diameter (BD), macular hole index (MHI), and diameter of ELM/EZ disruption. Change in BCVA from baseline was found to be significantly correlated with axial length and diameter hole index (DHI).Conclusions: Postoperative BCVA outcome was significantly correlated with integrity, thickness and reflectivity of the EZ band. Patients with smaller diameter of EZ disruption and higher reflectivity of EZ band tended to have better visual outcomes. Given that the EZ band reflects the recovery of mitochondria in photoreceptors, it is a promising parameter for their functional evaluation.
format	article
author	Jiarui Yang Huaqin Xia Yushi Liu Xinglin Wang Hao Yuan Qingyi Hou Yimeng Ge Yi Ding Yuexin Wang Changguan Wang Changguan Wang Xuemin Li Xuemin Li
author_facet	Jiarui Yang Huaqin Xia Yushi Liu Xinglin Wang Hao Yuan Qingyi Hou Yimeng Ge Yi Ding Yuexin Wang Changguan Wang Changguan Wang Xuemin Li Xuemin Li
author_sort	Jiarui Yang
title	Ellipsoid Zone and External Limiting Membrane-Related Parameters on Spectral Domain-Optical Coherence Tomography and Their Relationships With Visual Prognosis After Successful Macular Hole Surgery
title_short	Ellipsoid Zone and External Limiting Membrane-Related Parameters on Spectral Domain-Optical Coherence Tomography and Their Relationships With Visual Prognosis After Successful Macular Hole Surgery
title_full	Ellipsoid Zone and External Limiting Membrane-Related Parameters on Spectral Domain-Optical Coherence Tomography and Their Relationships With Visual Prognosis After Successful Macular Hole Surgery
title_fullStr	Ellipsoid Zone and External Limiting Membrane-Related Parameters on Spectral Domain-Optical Coherence Tomography and Their Relationships With Visual Prognosis After Successful Macular Hole Surgery
title_full_unstemmed	Ellipsoid Zone and External Limiting Membrane-Related Parameters on Spectral Domain-Optical Coherence Tomography and Their Relationships With Visual Prognosis After Successful Macular Hole Surgery
title_sort	ellipsoid zone and external limiting membrane-related parameters on spectral domain-optical coherence tomography and their relationships with visual prognosis after successful macular hole surgery
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ca7103ed9ba847e687b08c245822864a
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Ellipsoid Zone and External Limiting Membrane-Related Parameters on Spectral Domain-Optical Coherence Tomography and Their Relationships With Visual Prognosis After Successful Macular Hole Surgery

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