Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

Diffuse Intrinsic Pontine Gliomas are diagnosed by sampling a small portion of the tumour. Here, using multiple samples from tumours, the authors analyse the spatial and temporal distribution of driver mutations revealing that H3K27M mutations arise first in tumorigenesis followed by a specific inva...

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Autores principales:	Hamid Nikbakht, Eshini Panditharatna, Leonie G. Mikael, Rui Li, Tenzin Gayden, Matthew Osmond, Cheng-Ying Ho, Madhuri Kambhampati, Eugene I. Hwang, Damien Faury, Alan Siu, Simon Papillon-Cavanagh, Denise Bechet, Keith L. Ligon, Benjamin Ellezam, Wendy J. Ingram, Caedyn Stinson, Andrew S. Moore, Katherine E. Warren, Jason Karamchandani, Roger J. Packer, Nada Jabado, Jacek Majewski, Javad Nazarian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ca732472c78c4cee9e8f045e01b29088
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spelling	oai:doaj.org-article:ca732472c78c4cee9e8f045e01b290882021-12-02T16:49:24ZSpatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma10.1038/ncomms111852041-1723https://doaj.org/article/ca732472c78c4cee9e8f045e01b290882016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11185https://doaj.org/toc/2041-1723Diffuse Intrinsic Pontine Gliomas are diagnosed by sampling a small portion of the tumour. Here, using multiple samples from tumours, the authors analyse the spatial and temporal distribution of driver mutations revealing that H3K27M mutations arise first in tumorigenesis followed by a specific invariable sequence of driver mutations, which are homogeneously distributed across the tumour mass.Hamid NikbakhtEshini PanditharatnaLeonie G. MikaelRui LiTenzin GaydenMatthew OsmondCheng-Ying HoMadhuri KambhampatiEugene I. HwangDamien FauryAlan SiuSimon Papillon-CavanaghDenise BechetKeith L. LigonBenjamin EllezamWendy J. IngramCaedyn StinsonAndrew S. MooreKatherine E. WarrenJason KaramchandaniRoger J. PackerNada JabadoJacek MajewskiJavad NazarianNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hamid Nikbakht Eshini Panditharatna Leonie G. Mikael Rui Li Tenzin Gayden Matthew Osmond Cheng-Ying Ho Madhuri Kambhampati Eugene I. Hwang Damien Faury Alan Siu Simon Papillon-Cavanagh Denise Bechet Keith L. Ligon Benjamin Ellezam Wendy J. Ingram Caedyn Stinson Andrew S. Moore Katherine E. Warren Jason Karamchandani Roger J. Packer Nada Jabado Jacek Majewski Javad Nazarian Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
description	Diffuse Intrinsic Pontine Gliomas are diagnosed by sampling a small portion of the tumour. Here, using multiple samples from tumours, the authors analyse the spatial and temporal distribution of driver mutations revealing that H3K27M mutations arise first in tumorigenesis followed by a specific invariable sequence of driver mutations, which are homogeneously distributed across the tumour mass.
format	article
author	Hamid Nikbakht Eshini Panditharatna Leonie G. Mikael Rui Li Tenzin Gayden Matthew Osmond Cheng-Ying Ho Madhuri Kambhampati Eugene I. Hwang Damien Faury Alan Siu Simon Papillon-Cavanagh Denise Bechet Keith L. Ligon Benjamin Ellezam Wendy J. Ingram Caedyn Stinson Andrew S. Moore Katherine E. Warren Jason Karamchandani Roger J. Packer Nada Jabado Jacek Majewski Javad Nazarian
author_facet	Hamid Nikbakht Eshini Panditharatna Leonie G. Mikael Rui Li Tenzin Gayden Matthew Osmond Cheng-Ying Ho Madhuri Kambhampati Eugene I. Hwang Damien Faury Alan Siu Simon Papillon-Cavanagh Denise Bechet Keith L. Ligon Benjamin Ellezam Wendy J. Ingram Caedyn Stinson Andrew S. Moore Katherine E. Warren Jason Karamchandani Roger J. Packer Nada Jabado Jacek Majewski Javad Nazarian
author_sort	Hamid Nikbakht
title	Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
title_short	Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
title_full	Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
title_fullStr	Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
title_full_unstemmed	Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
title_sort	spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ca732472c78c4cee9e8f045e01b29088
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Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

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