Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test.

Spontaneous recognition tests, which utilize rodents' innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization p...

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Autores principales:	Shota Shimoda, Takaaki Ozawa, Yukio Ichitani, Kazuo Yamada
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca744df6e34544c38e2c4e925ab190cf
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id	oai:doaj.org-article:ca744df6e34544c38e2c4e925ab190cf
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spelling	oai:doaj.org-article:ca744df6e34544c38e2c4e925ab190cf2021-12-02T20:08:50ZLong-term associative memory in rats: Effects of familiarization period in object-place-context recognition test.1932-620310.1371/journal.pone.0254570https://doaj.org/article/ca744df6e34544c38e2c4e925ab190cf2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254570https://doaj.org/toc/1932-6203Spontaneous recognition tests, which utilize rodents' innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization period (sample phase) improved subsequent novelty discrimination in the spontaneous object, place, and object-place-context (OPC) recognition tests in rats. In the OPC recognition test, rats showed a significant novelty preference only when the familiarization period was 30 min but not when it was 5 min or 15 min. In addition, repeated 30-min familiarization periods extended the significant novelty preference to 72 hours. However, the rats exhibited a successful discrimination between the stayed and replaced objects under 15 min and 30 min familiarization period conditions in the place recognition test and between the novel and familiar objects under all conditions of 5, 15 and 30 min in the object recognition test. Our results suggest that the extension of the familiarization period improves performance in the spontaneous recognition paradigms, and a longer familiarization period is necessary for long-term associative recognition memory than for non-associative memory.Shota ShimodaTakaaki OzawaYukio IchitaniKazuo YamadaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254570 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shota Shimoda Takaaki Ozawa Yukio Ichitani Kazuo Yamada Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test.
description	Spontaneous recognition tests, which utilize rodents' innate tendency to explore novelty, can evaluate not only simple non-associative recognition memory but also more complex associative memory in animals. In the present study, we investigated whether the length of the object familiarization period (sample phase) improved subsequent novelty discrimination in the spontaneous object, place, and object-place-context (OPC) recognition tests in rats. In the OPC recognition test, rats showed a significant novelty preference only when the familiarization period was 30 min but not when it was 5 min or 15 min. In addition, repeated 30-min familiarization periods extended the significant novelty preference to 72 hours. However, the rats exhibited a successful discrimination between the stayed and replaced objects under 15 min and 30 min familiarization period conditions in the place recognition test and between the novel and familiar objects under all conditions of 5, 15 and 30 min in the object recognition test. Our results suggest that the extension of the familiarization period improves performance in the spontaneous recognition paradigms, and a longer familiarization period is necessary for long-term associative recognition memory than for non-associative memory.
format	article
author	Shota Shimoda Takaaki Ozawa Yukio Ichitani Kazuo Yamada
author_facet	Shota Shimoda Takaaki Ozawa Yukio Ichitani Kazuo Yamada
author_sort	Shota Shimoda
title	Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test.
title_short	Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test.
title_full	Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test.
title_fullStr	Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test.
title_full_unstemmed	Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test.
title_sort	long-term associative memory in rats: effects of familiarization period in object-place-context recognition test.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ca744df6e34544c38e2c4e925ab190cf
work_keys_str_mv	AT shotashimoda longtermassociativememoryinratseffectsoffamiliarizationperiodinobjectplacecontextrecognitiontest AT takaakiozawa longtermassociativememoryinratseffectsoffamiliarizationperiodinobjectplacecontextrecognitiontest AT yukioichitani longtermassociativememoryinratseffectsoffamiliarizationperiodinobjectplacecontextrecognitiontest AT kazuoyamada longtermassociativememoryinratseffectsoffamiliarizationperiodinobjectplacecontextrecognitiontest
_version_	1718375149746520064

Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test.

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