Serum levels of ICAM-I, VCAM, and Е-selectin in arterial hypertension with type 2 diabetes and obesity

Aim of this study was to determinate serum levels of ICAM-I, VCAM, and Е-selectin in patients whit arterial hypertension with or without type 2 diabetes mellitus and obesity. Material and Methods. We examined 41 hypertensive patients with type 2 diabetes, 18 obese hypertensive patients without di...

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Autor principal:	L.A. Mogylnytska
Formato:	article
Lenguaje:	EN UK
Publicado:	Danylo Halytsky Lviv National Medical University 2017
Materias:	icam-i, vcam, е-selectin, endothelial dysfunction, arterial hypertension, type 2 diabetes, obesity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ca7658ab36534511b71e5651c0345f06
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spelling	oai:doaj.org-article:ca7658ab36534511b71e5651c0345f062021-11-10T19:50:04ZSerum levels of ICAM-I, VCAM, and Е-selectin in arterial hypertension with type 2 diabetes and obesity1029-42442415-330310.25040/aml2017.04.015https://doaj.org/article/ca7658ab36534511b71e5651c0345f062017-12-01T00:00:00Zhttps://amljournal.com/index.php/journal/article/view/135https://doaj.org/toc/1029-4244https://doaj.org/toc/2415-3303Aim of this study was to determinate serum levels of ICAM-I, VCAM, and Е-selectin in patients whit arterial hypertension with or without type 2 diabetes mellitus and obesity. Material and Methods. We examined 41 hypertensive patients with type 2 diabetes, 18 obese hypertensive patients without diabetes, 10 normal weight hypertensive patients without diabetes, and 18 healthy control subjects. Serum levels of ICAM-I, VCAM, and Е-selectin were determined by immunoenzyme assay. The data were presented as means±SD. Statistical analysis was performed using the Mann-Whitney U-test, Pearson rank correlation coefficient, and multiple regression analysis. Results and Discussion. We found an increased serum level of ICAM-I in the hypertensive patients with type 2 diabetes, with and without obesity compared to the controls (253,11±51,09; 213,85±30,6; 177,66±27,59 and 147,48±6,06 ng/ml respectively, р<0,05). The serum level of VCAM was higher in hypertensive patients with type 2 diabetes, with and without obesity compared to the controls (736,53±100,87; 662,71±89,63; 518,3±70,32 and 437,33±37,69 ng/ml respectively, р<0,05). In thse patients the elevation of Е-selectin was compared to the controls (23,49±4,72; 19,02±3,53; 15,92±3,46 and 14,07±1,87 ng/ml respectively, р<0,05). We received a rise of ICAM-I, VCAM, and Е-selectin in hypertensive patients with diabetes compared to hypertensive patients with and without obesity (р<0,005). Also, the levels of ICAM-I, VCAM, and Е-selectin significantly correlated with HbA1c, serum insulin levels, HOMA, lipids, and body mass index (р<0,05). Conclusion. The revealed changes may reflect an endothelial dysfunction mostly pronounced in patients with arterial hypertension, type 2 diabetes mellitus, and obesity. Hyperglycemia, dyslipidemia, insulin resistance, and obesity appear to be significant contributing factors leading to the elevation of ICAM-I, VCAM, and Е-selectin levels.L.A. MogylnytskaDanylo Halytsky Lviv National Medical Universityarticleicam-i, vcam, е-selectin, endothelial dysfunction, arterial hypertension, type 2 diabetes, obesityMedicine (General)R5-920ENUKActa Medica Leopoliensia, Vol 23, Iss 4, Pp 15-21 (2017)
institution	DOAJ
collection	DOAJ
language	EN UK
topic	icam-i, vcam, е-selectin, endothelial dysfunction, arterial hypertension, type 2 diabetes, obesity Medicine (General) R5-920
spellingShingle	icam-i, vcam, е-selectin, endothelial dysfunction, arterial hypertension, type 2 diabetes, obesity Medicine (General) R5-920 L.A. Mogylnytska Serum levels of ICAM-I, VCAM, and Е-selectin in arterial hypertension with type 2 diabetes and obesity
description	Aim of this study was to determinate serum levels of ICAM-I, VCAM, and Е-selectin in patients whit arterial hypertension with or without type 2 diabetes mellitus and obesity. Material and Methods. We examined 41 hypertensive patients with type 2 diabetes, 18 obese hypertensive patients without diabetes, 10 normal weight hypertensive patients without diabetes, and 18 healthy control subjects. Serum levels of ICAM-I, VCAM, and Е-selectin were determined by immunoenzyme assay. The data were presented as means±SD. Statistical analysis was performed using the Mann-Whitney U-test, Pearson rank correlation coefficient, and multiple regression analysis. Results and Discussion. We found an increased serum level of ICAM-I in the hypertensive patients with type 2 diabetes, with and without obesity compared to the controls (253,11±51,09; 213,85±30,6; 177,66±27,59 and 147,48±6,06 ng/ml respectively, р<0,05). The serum level of VCAM was higher in hypertensive patients with type 2 diabetes, with and without obesity compared to the controls (736,53±100,87; 662,71±89,63; 518,3±70,32 and 437,33±37,69 ng/ml respectively, р<0,05). In thse patients the elevation of Е-selectin was compared to the controls (23,49±4,72; 19,02±3,53; 15,92±3,46 and 14,07±1,87 ng/ml respectively, р<0,05). We received a rise of ICAM-I, VCAM, and Е-selectin in hypertensive patients with diabetes compared to hypertensive patients with and without obesity (р<0,005). Also, the levels of ICAM-I, VCAM, and Е-selectin significantly correlated with HbA1c, serum insulin levels, HOMA, lipids, and body mass index (р<0,05). Conclusion. The revealed changes may reflect an endothelial dysfunction mostly pronounced in patients with arterial hypertension, type 2 diabetes mellitus, and obesity. Hyperglycemia, dyslipidemia, insulin resistance, and obesity appear to be significant contributing factors leading to the elevation of ICAM-I, VCAM, and Е-selectin levels.
format	article
author	L.A. Mogylnytska
author_facet	L.A. Mogylnytska
author_sort	L.A. Mogylnytska
title	Serum levels of ICAM-I, VCAM, and Е-selectin in arterial hypertension with type 2 diabetes and obesity
title_short	Serum levels of ICAM-I, VCAM, and Е-selectin in arterial hypertension with type 2 diabetes and obesity
title_full	Serum levels of ICAM-I, VCAM, and Е-selectin in arterial hypertension with type 2 diabetes and obesity
title_fullStr	Serum levels of ICAM-I, VCAM, and Е-selectin in arterial hypertension with type 2 diabetes and obesity
title_full_unstemmed	Serum levels of ICAM-I, VCAM, and Е-selectin in arterial hypertension with type 2 diabetes and obesity
title_sort	serum levels of icam-i, vcam, and е-selectin in arterial hypertension with type 2 diabetes and obesity
publisher	Danylo Halytsky Lviv National Medical University
publishDate	2017
url	https://doaj.org/article/ca7658ab36534511b71e5651c0345f06
work_keys_str_mv	AT lamogylnytska serumlevelsoficamivcamandeselectininarterialhypertensionwithtype2diabetesandobesity
_version_	1718439722529849344

Serum levels of ICAM-I, VCAM, and Е-selectin in arterial hypertension with type 2 diabetes and obesity

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