Heavy-ion production of 77Br and 76Br

Abstract Many radioisotopes with potential medical applications are difficult to produce routinely, especially those on the proton-rich side of the valley of stability. Current production methods typically use light-ion (protons or deuteron) reactions on materials of similar mass to the target radio...

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Autores principales:	Sean R. McGuinness, John T. Wilkinson, Graham F. Peaslee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca79e3d871fe44839d30da7c2880780b
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spelling	oai:doaj.org-article:ca79e3d871fe44839d30da7c2880780b2021-12-02T17:06:10ZHeavy-ion production of 77Br and 76Br10.1038/s41598-021-94922-x2045-2322https://doaj.org/article/ca79e3d871fe44839d30da7c2880780b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94922-xhttps://doaj.org/toc/2045-2322Abstract Many radioisotopes with potential medical applications are difficult to produce routinely, especially those on the proton-rich side of the valley of stability. Current production methods typically use light-ion (protons or deuteron) reactions on materials of similar mass to the target radioisotope, which limits the elemental target material available and may require the use of targets with poor thermal properties (as is the case for the production of radiobromine). These reactions may also create significant amounts of proton-rich decay products which require chemical separation from the desired product in a highly radioactive environment. A promising alternative method using heavy-ion fusion-evaporation reactions for the production of the medically relevant bromine radioisotopes 76Br (t1/2 = 16.2 h) and 77Br (t1/2 = 57.0 h) is presented. Heavy-ion beams of 28Si and 16O were used to bombard natural chromium and copper targets just above the Coulomb barrier at the University of Notre Dame's Nuclear Science Laboratory to produce these bromine and precursor radioisotopes by fusion-evaporation reactions. Production yields for these reactions were measured and compared to PACE4 calculations. In addition to using more robust targets for irradiation, a simple physical–chemical separation method is proposed that will lead to very high radiopurity yields. A summary of accelerator facility requirements needed for routine production of these radioisotopes is also presented.Sean R. McGuinnessJohn T. WilkinsonGraham F. PeasleeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sean R. McGuinness John T. Wilkinson Graham F. Peaslee Heavy-ion production of 77Br and 76Br
description	Abstract Many radioisotopes with potential medical applications are difficult to produce routinely, especially those on the proton-rich side of the valley of stability. Current production methods typically use light-ion (protons or deuteron) reactions on materials of similar mass to the target radioisotope, which limits the elemental target material available and may require the use of targets with poor thermal properties (as is the case for the production of radiobromine). These reactions may also create significant amounts of proton-rich decay products which require chemical separation from the desired product in a highly radioactive environment. A promising alternative method using heavy-ion fusion-evaporation reactions for the production of the medically relevant bromine radioisotopes 76Br (t1/2 = 16.2 h) and 77Br (t1/2 = 57.0 h) is presented. Heavy-ion beams of 28Si and 16O were used to bombard natural chromium and copper targets just above the Coulomb barrier at the University of Notre Dame's Nuclear Science Laboratory to produce these bromine and precursor radioisotopes by fusion-evaporation reactions. Production yields for these reactions were measured and compared to PACE4 calculations. In addition to using more robust targets for irradiation, a simple physical–chemical separation method is proposed that will lead to very high radiopurity yields. A summary of accelerator facility requirements needed for routine production of these radioisotopes is also presented.
format	article
author	Sean R. McGuinness John T. Wilkinson Graham F. Peaslee
author_facet	Sean R. McGuinness John T. Wilkinson Graham F. Peaslee
author_sort	Sean R. McGuinness
title	Heavy-ion production of 77Br and 76Br
title_short	Heavy-ion production of 77Br and 76Br
title_full	Heavy-ion production of 77Br and 76Br
title_fullStr	Heavy-ion production of 77Br and 76Br
title_full_unstemmed	Heavy-ion production of 77Br and 76Br
title_sort	heavy-ion production of 77br and 76br
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ca79e3d871fe44839d30da7c2880780b
work_keys_str_mv	AT seanrmcguinness heavyionproductionof77brand76br AT johntwilkinson heavyionproductionof77brand76br AT grahamfpeaslee heavyionproductionof77brand76br
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Heavy-ion production of 77Br and 76Br

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