Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS

Liquid biopsies allow the non-invasive detection of somatic mutations from tumours. Here, the authors develop and test MSK-ACCESS, an NGS-based clinical assay for identifying low frequency mutations in 129 genes and describe how it benefits patients in the clinic.

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Autores principales:	A. Rose Brannon, Gowtham Jayakumaran, Monica Diosdado, Juber Patel, Anna Razumova, Yu Hu, Fanli Meng, Mohammad Haque, Justyna Sadowska, Brian J. Murphy, Tessara Baldi, Ian Johnson, Ryan Ptashkin, Maysun Hasan, Preethi Srinivasan, Anoop Balakrishnan Rema, Ivelise Rijo, Aaron Agarunov, Helen Won, Dilmi Perera, David N. Brown, Aliaksandra Samoila, Xiaohong Jing, Erika Gedvilaite, Julie L. Yang, Dennis P. Stephens, Jenna-Marie Dix, Nicole DeGroat, Khedoudja Nafa, Aijazuddin Syed, Alan Li, Emily S. Lebow, Anita S. Bowman, Donna C. Ferguson, Ying Liu, Douglas A. Mata, Rohit Sharma, Soo-Ryum Yang, Tejus Bale, Jamal K. Benhamida, Jason C. Chang, Snjezana Dogan, Meera R. Hameed, Jaclyn F. Hechtman, Christine Moung, Dara S. Ross, Efsevia Vakiani, Chad M. Vanderbilt, JinJuan Yao, Pedram Razavi, Lillian M. Smyth, Sarat Chandarlapaty, Gopa Iyer, Wassim Abida, James J. Harding, Benjamin Krantz, Eileen O’Reilly, Helena A. Yu, Bob T. Li, Charles M. Rudin, Luis Diaz, David B. Solit, Maria E. Arcila, Marc Ladanyi, Brian Loomis, Dana Tsui, Michael F. Berger, Ahmet Zehir, Ryma Benayed
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ca7c61a9651341a5819f1ee6a4c47bfa
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spelling	oai:doaj.org-article:ca7c61a9651341a5819f1ee6a4c47bfa2021-12-02T17:24:08ZEnhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS10.1038/s41467-021-24109-52041-1723https://doaj.org/article/ca7c61a9651341a5819f1ee6a4c47bfa2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24109-5https://doaj.org/toc/2041-1723Liquid biopsies allow the non-invasive detection of somatic mutations from tumours. Here, the authors develop and test MSK-ACCESS, an NGS-based clinical assay for identifying low frequency mutations in 129 genes and describe how it benefits patients in the clinic.A. Rose BrannonGowtham JayakumaranMonica DiosdadoJuber PatelAnna RazumovaYu HuFanli MengMohammad HaqueJustyna SadowskaBrian J. MurphyTessara BaldiIan JohnsonRyan PtashkinMaysun HasanPreethi SrinivasanAnoop Balakrishnan RemaIvelise RijoAaron AgarunovHelen WonDilmi PereraDavid N. BrownAliaksandra SamoilaXiaohong JingErika GedvilaiteJulie L. YangDennis P. StephensJenna-Marie DixNicole DeGroatKhedoudja NafaAijazuddin SyedAlan LiEmily S. LebowAnita S. BowmanDonna C. FergusonYing LiuDouglas A. MataRohit SharmaSoo-Ryum YangTejus BaleJamal K. BenhamidaJason C. ChangSnjezana DoganMeera R. HameedJaclyn F. HechtmanChristine MoungDara S. RossEfsevia VakianiChad M. VanderbiltJinJuan YaoPedram RazaviLillian M. SmythSarat ChandarlapatyGopa IyerWassim AbidaJames J. HardingBenjamin KrantzEileen O’ReillyHelena A. YuBob T. LiCharles M. RudinLuis DiazDavid B. SolitMaria E. ArcilaMarc LadanyiBrian LoomisDana TsuiMichael F. BergerAhmet ZehirRyma BenayedNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Rose Brannon Gowtham Jayakumaran Monica Diosdado Juber Patel Anna Razumova Yu Hu Fanli Meng Mohammad Haque Justyna Sadowska Brian J. Murphy Tessara Baldi Ian Johnson Ryan Ptashkin Maysun Hasan Preethi Srinivasan Anoop Balakrishnan Rema Ivelise Rijo Aaron Agarunov Helen Won Dilmi Perera David N. Brown Aliaksandra Samoila Xiaohong Jing Erika Gedvilaite Julie L. Yang Dennis P. Stephens Jenna-Marie Dix Nicole DeGroat Khedoudja Nafa Aijazuddin Syed Alan Li Emily S. Lebow Anita S. Bowman Donna C. Ferguson Ying Liu Douglas A. Mata Rohit Sharma Soo-Ryum Yang Tejus Bale Jamal K. Benhamida Jason C. Chang Snjezana Dogan Meera R. Hameed Jaclyn F. Hechtman Christine Moung Dara S. Ross Efsevia Vakiani Chad M. Vanderbilt JinJuan Yao Pedram Razavi Lillian M. Smyth Sarat Chandarlapaty Gopa Iyer Wassim Abida James J. Harding Benjamin Krantz Eileen O’Reilly Helena A. Yu Bob T. Li Charles M. Rudin Luis Diaz David B. Solit Maria E. Arcila Marc Ladanyi Brian Loomis Dana Tsui Michael F. Berger Ahmet Zehir Ryma Benayed Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS
description	Liquid biopsies allow the non-invasive detection of somatic mutations from tumours. Here, the authors develop and test MSK-ACCESS, an NGS-based clinical assay for identifying low frequency mutations in 129 genes and describe how it benefits patients in the clinic.
format	article
author	A. Rose Brannon Gowtham Jayakumaran Monica Diosdado Juber Patel Anna Razumova Yu Hu Fanli Meng Mohammad Haque Justyna Sadowska Brian J. Murphy Tessara Baldi Ian Johnson Ryan Ptashkin Maysun Hasan Preethi Srinivasan Anoop Balakrishnan Rema Ivelise Rijo Aaron Agarunov Helen Won Dilmi Perera David N. Brown Aliaksandra Samoila Xiaohong Jing Erika Gedvilaite Julie L. Yang Dennis P. Stephens Jenna-Marie Dix Nicole DeGroat Khedoudja Nafa Aijazuddin Syed Alan Li Emily S. Lebow Anita S. Bowman Donna C. Ferguson Ying Liu Douglas A. Mata Rohit Sharma Soo-Ryum Yang Tejus Bale Jamal K. Benhamida Jason C. Chang Snjezana Dogan Meera R. Hameed Jaclyn F. Hechtman Christine Moung Dara S. Ross Efsevia Vakiani Chad M. Vanderbilt JinJuan Yao Pedram Razavi Lillian M. Smyth Sarat Chandarlapaty Gopa Iyer Wassim Abida James J. Harding Benjamin Krantz Eileen O’Reilly Helena A. Yu Bob T. Li Charles M. Rudin Luis Diaz David B. Solit Maria E. Arcila Marc Ladanyi Brian Loomis Dana Tsui Michael F. Berger Ahmet Zehir Ryma Benayed
author_facet	A. Rose Brannon Gowtham Jayakumaran Monica Diosdado Juber Patel Anna Razumova Yu Hu Fanli Meng Mohammad Haque Justyna Sadowska Brian J. Murphy Tessara Baldi Ian Johnson Ryan Ptashkin Maysun Hasan Preethi Srinivasan Anoop Balakrishnan Rema Ivelise Rijo Aaron Agarunov Helen Won Dilmi Perera David N. Brown Aliaksandra Samoila Xiaohong Jing Erika Gedvilaite Julie L. Yang Dennis P. Stephens Jenna-Marie Dix Nicole DeGroat Khedoudja Nafa Aijazuddin Syed Alan Li Emily S. Lebow Anita S. Bowman Donna C. Ferguson Ying Liu Douglas A. Mata Rohit Sharma Soo-Ryum Yang Tejus Bale Jamal K. Benhamida Jason C. Chang Snjezana Dogan Meera R. Hameed Jaclyn F. Hechtman Christine Moung Dara S. Ross Efsevia Vakiani Chad M. Vanderbilt JinJuan Yao Pedram Razavi Lillian M. Smyth Sarat Chandarlapaty Gopa Iyer Wassim Abida James J. Harding Benjamin Krantz Eileen O’Reilly Helena A. Yu Bob T. Li Charles M. Rudin Luis Diaz David B. Solit Maria E. Arcila Marc Ladanyi Brian Loomis Dana Tsui Michael F. Berger Ahmet Zehir Ryma Benayed
author_sort	A. Rose Brannon
title	Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS
title_short	Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS
title_full	Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS
title_fullStr	Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS
title_full_unstemmed	Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS
title_sort	enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free dna via paired normal sequencing using msk-access
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ca7c61a9651341a5819f1ee6a4c47bfa
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Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS

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