Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases

Inflammatory bowel diseases (IBD) comprise a distinct set of clinical symptoms resulting from chronic inflammation within the gastrointestinal (GI) tract. Despite the significant progress in understanding the etiology and development of treatment strategies, IBD remain incurable for thousands of pat...

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Autores principales:	Lidiya V. Boldyreva, Maryana V. Morozova, Snezhanna S. Saydakova, Elena N. Kozhevnikova
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	IBD Crohn’s disease ulcerative colitis phosphatidylcholine lysophosphatidylcholine phosphatidylethanolamine Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ca7f68fc3d274d98b14d5ea15fe7cb46
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spelling	oai:doaj.org-article:ca7f68fc3d274d98b14d5ea15fe7cb462021-11-11T17:08:42ZFat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases10.3390/ijms2221116821422-00671661-6596https://doaj.org/article/ca7f68fc3d274d98b14d5ea15fe7cb462021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11682https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Inflammatory bowel diseases (IBD) comprise a distinct set of clinical symptoms resulting from chronic inflammation within the gastrointestinal (GI) tract. Despite the significant progress in understanding the etiology and development of treatment strategies, IBD remain incurable for thousands of patients. Metabolic deregulation is indicative of IBD, including substantial shifts in lipid metabolism. Recent data showed that changes in some phospholipids are very common in IBD patients. For instance, phosphatidylcholine (PC)/phosphatidylethanolamine (PE) and lysophosphatidylcholine (LPC)/PC ratios are associated with the severity of the inflammatory process. Composition of phospholipids also changes upon IBD towards an increase in arachidonic acid and a decrease in linoleic and a-linolenic acid levels. Moreover, an increase in certain phospholipid metabolites, such as lysophosphatidylcholine, sphingosine-1-phosphate and ceramide, can result in enhanced intestinal inflammation, malignancy, apoptosis or necroptosis. Because some phospholipids are associated with pathogenesis of IBD, they may provide a basis for new strategies to treat IBD. Current attempts are aimed at controlling phospholipid and fatty acid levels through the diet or via pharmacological manipulation of lipid metabolism.Lidiya V. BoldyrevaMaryana V. MorozovaSnezhanna S. SaydakovaElena N. KozhevnikovaMDPI AGarticleIBDCrohn’s diseaseulcerative colitisphosphatidylcholinelysophosphatidylcholinephosphatidylethanolamineBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11682, p 11682 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	IBD Crohn’s disease ulcerative colitis phosphatidylcholine lysophosphatidylcholine phosphatidylethanolamine Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	IBD Crohn’s disease ulcerative colitis phosphatidylcholine lysophosphatidylcholine phosphatidylethanolamine Biology (General) QH301-705.5 Chemistry QD1-999 Lidiya V. Boldyreva Maryana V. Morozova Snezhanna S. Saydakova Elena N. Kozhevnikova Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases
description	Inflammatory bowel diseases (IBD) comprise a distinct set of clinical symptoms resulting from chronic inflammation within the gastrointestinal (GI) tract. Despite the significant progress in understanding the etiology and development of treatment strategies, IBD remain incurable for thousands of patients. Metabolic deregulation is indicative of IBD, including substantial shifts in lipid metabolism. Recent data showed that changes in some phospholipids are very common in IBD patients. For instance, phosphatidylcholine (PC)/phosphatidylethanolamine (PE) and lysophosphatidylcholine (LPC)/PC ratios are associated with the severity of the inflammatory process. Composition of phospholipids also changes upon IBD towards an increase in arachidonic acid and a decrease in linoleic and a-linolenic acid levels. Moreover, an increase in certain phospholipid metabolites, such as lysophosphatidylcholine, sphingosine-1-phosphate and ceramide, can result in enhanced intestinal inflammation, malignancy, apoptosis or necroptosis. Because some phospholipids are associated with pathogenesis of IBD, they may provide a basis for new strategies to treat IBD. Current attempts are aimed at controlling phospholipid and fatty acid levels through the diet or via pharmacological manipulation of lipid metabolism.
format	article
author	Lidiya V. Boldyreva Maryana V. Morozova Snezhanna S. Saydakova Elena N. Kozhevnikova
author_facet	Lidiya V. Boldyreva Maryana V. Morozova Snezhanna S. Saydakova Elena N. Kozhevnikova
author_sort	Lidiya V. Boldyreva
title	Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases
title_short	Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases
title_full	Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases
title_fullStr	Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases
title_full_unstemmed	Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases
title_sort	fat of the gut: epithelial phospholipids in inflammatory bowel diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ca7f68fc3d274d98b14d5ea15fe7cb46
work_keys_str_mv	AT lidiyavboldyreva fatofthegutepithelialphospholipidsininflammatoryboweldiseases AT maryanavmorozova fatofthegutepithelialphospholipidsininflammatoryboweldiseases AT snezhannassaydakova fatofthegutepithelialphospholipidsininflammatoryboweldiseases AT elenankozhevnikova fatofthegutepithelialphospholipidsininflammatoryboweldiseases
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Fat of the Gut: Epithelial Phospholipids in Inflammatory Bowel Diseases

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