Decreased rate of evolution in Y chromosome STR loci of increased size of the repeat unit.

<h4>Background</h4>Polymorphic Y chromosome short tandem repeats (STRs) have been widely used in population genetic and evolutionary studies. Compared to di-, tri-, and tetranucleotide repeats, STRs with longer repeat units occur more rarely and are far less commonly used.<h4>Princ...

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Autores principales:	Mari Järve, Lev A Zhivotovsky, Siiri Rootsi, Hela Help, Evgeny I Rogaev, Elza K Khusnutdinova, Toomas Kivisild, Juan J Sanchez
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca858e444cdb4a198f95618d1c3c3b47
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spelling	oai:doaj.org-article:ca858e444cdb4a198f95618d1c3c3b472021-11-25T06:20:00ZDecreased rate of evolution in Y chromosome STR loci of increased size of the repeat unit.1932-620310.1371/journal.pone.0007276https://doaj.org/article/ca858e444cdb4a198f95618d1c3c3b472009-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19789645/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Polymorphic Y chromosome short tandem repeats (STRs) have been widely used in population genetic and evolutionary studies. Compared to di-, tri-, and tetranucleotide repeats, STRs with longer repeat units occur more rarely and are far less commonly used.<h4>Principal findings</h4>In order to study the evolutionary dynamics of STRs according to repeat unit size, we analysed variation at 24 Y chromosome repeat loci: 1 tri-, 14 tetra-, 7 penta-, and 2 hexanucleotide loci. According to our results, penta- and hexanucleotide repeats have approximately two times lower repeat variance and diversity than tri- and tetranucleotide repeats, indicating that their mutation rate is about half of that of tri- and tetranucleotide repeats. Thus, STR markers with longer repeat units are more robust in distinguishing Y chromosome haplogroups and, in some cases, phylogenetic splits within established haplogroups.<h4>Conclusions</h4>Our findings suggest that Y chromosome STRs of increased repeat unit size have a lower rate of evolution, which has significant relevance in population genetic and evolutionary studies.Mari JärveLev A ZhivotovskySiiri RootsiHela HelpEvgeny I RogaevElza K KhusnutdinovaToomas KivisildJuan J SanchezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 9, p e7276 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mari Järve Lev A Zhivotovsky Siiri Rootsi Hela Help Evgeny I Rogaev Elza K Khusnutdinova Toomas Kivisild Juan J Sanchez Decreased rate of evolution in Y chromosome STR loci of increased size of the repeat unit.
description	<h4>Background</h4>Polymorphic Y chromosome short tandem repeats (STRs) have been widely used in population genetic and evolutionary studies. Compared to di-, tri-, and tetranucleotide repeats, STRs with longer repeat units occur more rarely and are far less commonly used.<h4>Principal findings</h4>In order to study the evolutionary dynamics of STRs according to repeat unit size, we analysed variation at 24 Y chromosome repeat loci: 1 tri-, 14 tetra-, 7 penta-, and 2 hexanucleotide loci. According to our results, penta- and hexanucleotide repeats have approximately two times lower repeat variance and diversity than tri- and tetranucleotide repeats, indicating that their mutation rate is about half of that of tri- and tetranucleotide repeats. Thus, STR markers with longer repeat units are more robust in distinguishing Y chromosome haplogroups and, in some cases, phylogenetic splits within established haplogroups.<h4>Conclusions</h4>Our findings suggest that Y chromosome STRs of increased repeat unit size have a lower rate of evolution, which has significant relevance in population genetic and evolutionary studies.
format	article
author	Mari Järve Lev A Zhivotovsky Siiri Rootsi Hela Help Evgeny I Rogaev Elza K Khusnutdinova Toomas Kivisild Juan J Sanchez
author_facet	Mari Järve Lev A Zhivotovsky Siiri Rootsi Hela Help Evgeny I Rogaev Elza K Khusnutdinova Toomas Kivisild Juan J Sanchez
author_sort	Mari Järve
title	Decreased rate of evolution in Y chromosome STR loci of increased size of the repeat unit.
title_short	Decreased rate of evolution in Y chromosome STR loci of increased size of the repeat unit.
title_full	Decreased rate of evolution in Y chromosome STR loci of increased size of the repeat unit.
title_fullStr	Decreased rate of evolution in Y chromosome STR loci of increased size of the repeat unit.
title_full_unstemmed	Decreased rate of evolution in Y chromosome STR loci of increased size of the repeat unit.
title_sort	decreased rate of evolution in y chromosome str loci of increased size of the repeat unit.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/ca858e444cdb4a198f95618d1c3c3b47
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Decreased rate of evolution in Y chromosome STR loci of increased size of the repeat unit.

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