Admission serum potassium levels and prognosis of vasospastic angina

Abstract Hypokalemia is a common electrolyte disturbance and is related to poor prognosis in patients with cardiovascular disease. However, the role of hypokalemia in patients with vasospastic angina (VSA) has not yet been studied. The present study enrolled 1454 patients diagnosed with VSA accordin...

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Autores principales:	Won-Woo Seo, Sang-Ho Jo, Sung Eun Kim, Hyun-Jin Kim, Seung Hwan Han, Kwan Yong Lee, Sung Ho Her, Min-Ho Lee, Seong-Sik Cho, Hack-Lyoung Kim, Sang Hong Baek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca85c4c51a1246688a74a64fe6884717
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spelling	oai:doaj.org-article:ca85c4c51a1246688a74a64fe68847172021-12-02T13:30:11ZAdmission serum potassium levels and prognosis of vasospastic angina10.1038/s41598-021-84712-w2045-2322https://doaj.org/article/ca85c4c51a1246688a74a64fe68847172021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84712-whttps://doaj.org/toc/2045-2322Abstract Hypokalemia is a common electrolyte disturbance and is related to poor prognosis in patients with cardiovascular disease. However, the role of hypokalemia in patients with vasospastic angina (VSA) has not yet been studied. The present study enrolled 1454 patients diagnosed with VSA according to ergonovine provocation test results and available admission serum potassium data. The primary outcome was a composite of cardiac death, acute coronary syndrome, and new-onset life-threatening arrhythmia. Based on a hypokalemia definition as serum potassium concentration ≤ 3.5 mEq/L, the hypokalaemia group included 70 patients (4.8%). The median potassium levels were 3.4 mEq/L [interquartile range (IQR) 3.3–3.5] in the hypokalemia group and 4.1 mEq/L (IQR 3.9–4.3) in the no-hypokalemia group. The median follow-up duration was 764 days. Primary outcomes occurred in seven patients (10.0%) in the hypokalemia group and 51 patients (3.7%) in the no-hypokalemia group. The Kaplan–Meier analysis showed a higher cumulative incidence of primary outcomes in the hypokalemia group compared to that in the no-hypokalemia group (log-rank P = 0.014). Multivariate Cox regression analysis also showed that hypokalemia was an independent predictor of primary outcomes. In conclusion, hypokalemia at admission was associated with adverse clinical outcomes in VSA.Won-Woo SeoSang-Ho JoSung Eun KimHyun-Jin KimSeung Hwan HanKwan Yong LeeSung Ho HerMin-Ho LeeSeong-Sik ChoHack-Lyoung KimSang Hong BaekNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Won-Woo Seo Sang-Ho Jo Sung Eun Kim Hyun-Jin Kim Seung Hwan Han Kwan Yong Lee Sung Ho Her Min-Ho Lee Seong-Sik Cho Hack-Lyoung Kim Sang Hong Baek Admission serum potassium levels and prognosis of vasospastic angina
description	Abstract Hypokalemia is a common electrolyte disturbance and is related to poor prognosis in patients with cardiovascular disease. However, the role of hypokalemia in patients with vasospastic angina (VSA) has not yet been studied. The present study enrolled 1454 patients diagnosed with VSA according to ergonovine provocation test results and available admission serum potassium data. The primary outcome was a composite of cardiac death, acute coronary syndrome, and new-onset life-threatening arrhythmia. Based on a hypokalemia definition as serum potassium concentration ≤ 3.5 mEq/L, the hypokalaemia group included 70 patients (4.8%). The median potassium levels were 3.4 mEq/L [interquartile range (IQR) 3.3–3.5] in the hypokalemia group and 4.1 mEq/L (IQR 3.9–4.3) in the no-hypokalemia group. The median follow-up duration was 764 days. Primary outcomes occurred in seven patients (10.0%) in the hypokalemia group and 51 patients (3.7%) in the no-hypokalemia group. The Kaplan–Meier analysis showed a higher cumulative incidence of primary outcomes in the hypokalemia group compared to that in the no-hypokalemia group (log-rank P = 0.014). Multivariate Cox regression analysis also showed that hypokalemia was an independent predictor of primary outcomes. In conclusion, hypokalemia at admission was associated with adverse clinical outcomes in VSA.
format	article
author	Won-Woo Seo Sang-Ho Jo Sung Eun Kim Hyun-Jin Kim Seung Hwan Han Kwan Yong Lee Sung Ho Her Min-Ho Lee Seong-Sik Cho Hack-Lyoung Kim Sang Hong Baek
author_facet	Won-Woo Seo Sang-Ho Jo Sung Eun Kim Hyun-Jin Kim Seung Hwan Han Kwan Yong Lee Sung Ho Her Min-Ho Lee Seong-Sik Cho Hack-Lyoung Kim Sang Hong Baek
author_sort	Won-Woo Seo
title	Admission serum potassium levels and prognosis of vasospastic angina
title_short	Admission serum potassium levels and prognosis of vasospastic angina
title_full	Admission serum potassium levels and prognosis of vasospastic angina
title_fullStr	Admission serum potassium levels and prognosis of vasospastic angina
title_full_unstemmed	Admission serum potassium levels and prognosis of vasospastic angina
title_sort	admission serum potassium levels and prognosis of vasospastic angina
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ca85c4c51a1246688a74a64fe6884717
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Admission serum potassium levels and prognosis of vasospastic angina

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