Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function

Reyes et al. identified and characterized dominant mutations in the MutL homolog MLH2 (in S. cerevisiae) and PMS1 (in humans) causing an increased mutator phenotype. Based on their findings, they propose that Mlh2/hPMS1-Mlh1 mutant complexes can act as roadblocks on DNA preventing mismatch repair fu...

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Autores principales:	Gloria X. Reyes, Boyu Zhao, Tobias T. Schmidt, Kerstin Gries, Matthias Kloor, Hans Hombauer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ca8b2b28c21f4262a1051bb3ba633b91
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spelling	oai:doaj.org-article:ca8b2b28c21f4262a1051bb3ba633b912021-12-02T12:33:13ZIdentification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function10.1038/s42003-020-01481-42399-3642https://doaj.org/article/ca8b2b28c21f4262a1051bb3ba633b912020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01481-4https://doaj.org/toc/2399-3642Reyes et al. identified and characterized dominant mutations in the MutL homolog MLH2 (in S. cerevisiae) and PMS1 (in humans) causing an increased mutator phenotype. Based on their findings, they propose that Mlh2/hPMS1-Mlh1 mutant complexes can act as roadblocks on DNA preventing mismatch repair function.Gloria X. ReyesBoyu ZhaoTobias T. SchmidtKerstin GriesMatthias KloorHans HombauerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Gloria X. Reyes Boyu Zhao Tobias T. Schmidt Kerstin Gries Matthias Kloor Hans Hombauer Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function
description	Reyes et al. identified and characterized dominant mutations in the MutL homolog MLH2 (in S. cerevisiae) and PMS1 (in humans) causing an increased mutator phenotype. Based on their findings, they propose that Mlh2/hPMS1-Mlh1 mutant complexes can act as roadblocks on DNA preventing mismatch repair function.
format	article
author	Gloria X. Reyes Boyu Zhao Tobias T. Schmidt Kerstin Gries Matthias Kloor Hans Hombauer
author_facet	Gloria X. Reyes Boyu Zhao Tobias T. Schmidt Kerstin Gries Matthias Kloor Hans Hombauer
author_sort	Gloria X. Reyes
title	Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function
title_short	Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function
title_full	Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function
title_fullStr	Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function
title_full_unstemmed	Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function
title_sort	identification of mlh2/hpms1 dominant mutations that prevent dna mismatch repair function
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ca8b2b28c21f4262a1051bb3ba633b91
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Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function

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