Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus

Abstract Extensive phytochemical investigation on the whole herbs of Delphinium anthriscifolium var. majus led to the identification of fourteen diterpenoid alkaloids, including three new C20–diterpenoid alkaloids (anthriscifolsines A–C, 1–3), six new C19–diterpenoid alkaloids (anthriscifolrines A–F...

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Main Authors:	Lian-Hai Shan, Ji-Fa Zhang, Feng Gao, Shuai Huang, Xian-Li Zhou
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Medicine R Science Q
Online Access:	https://doaj.org/article/ca8d4a381afd4a3e9fad5f118094e8f1
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id	oai:doaj.org-article:ca8d4a381afd4a3e9fad5f118094e8f1
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spelling	oai:doaj.org-article:ca8d4a381afd4a3e9fad5f118094e8f12021-12-02T15:05:19ZDiterpenoid Alkaloids from Delphinium anthriscifolium var. majus10.1038/s41598-017-05372-32045-2322https://doaj.org/article/ca8d4a381afd4a3e9fad5f118094e8f12017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05372-3https://doaj.org/toc/2045-2322Abstract Extensive phytochemical investigation on the whole herbs of Delphinium anthriscifolium var. majus led to the identification of fourteen diterpenoid alkaloids, including three new C20–diterpenoid alkaloids (anthriscifolsines A–C, 1–3), six new C19–diterpenoid alkaloids (anthriscifolrines A–F, 4–9), and five know compounds (10–14). Among them, anthriscifolsine A represents a novel C20–diterpenoid alkaloid characterized by a seco C–ring. The structures of the isolated compounds were elucidated by extensive spectroscopic methods, including HR-ESI–MS, X–ray, and 1D and 2D NMR experiments. Bioactivity of compounds 3–6 was evaluated for their cytotoxicity against the MCF–7, HepG2 and H460 cancer cell lines.Lian-Hai ShanJi-Fa ZhangFeng GaoShuai HuangXian-Li ZhouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lian-Hai Shan Ji-Fa Zhang Feng Gao Shuai Huang Xian-Li Zhou Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus
description	Abstract Extensive phytochemical investigation on the whole herbs of Delphinium anthriscifolium var. majus led to the identification of fourteen diterpenoid alkaloids, including three new C20–diterpenoid alkaloids (anthriscifolsines A–C, 1–3), six new C19–diterpenoid alkaloids (anthriscifolrines A–F, 4–9), and five know compounds (10–14). Among them, anthriscifolsine A represents a novel C20–diterpenoid alkaloid characterized by a seco C–ring. The structures of the isolated compounds were elucidated by extensive spectroscopic methods, including HR-ESI–MS, X–ray, and 1D and 2D NMR experiments. Bioactivity of compounds 3–6 was evaluated for their cytotoxicity against the MCF–7, HepG2 and H460 cancer cell lines.
format	article
author	Lian-Hai Shan Ji-Fa Zhang Feng Gao Shuai Huang Xian-Li Zhou
author_facet	Lian-Hai Shan Ji-Fa Zhang Feng Gao Shuai Huang Xian-Li Zhou
author_sort	Lian-Hai Shan
title	Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus
title_short	Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus
title_full	Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus
title_fullStr	Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus
title_full_unstemmed	Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus
title_sort	diterpenoid alkaloids from delphinium anthriscifolium var. majus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ca8d4a381afd4a3e9fad5f118094e8f1
work_keys_str_mv	AT lianhaishan diterpenoidalkaloidsfromdelphiniumanthriscifoliumvarmajus AT jifazhang diterpenoidalkaloidsfromdelphiniumanthriscifoliumvarmajus AT fenggao diterpenoidalkaloidsfromdelphiniumanthriscifoliumvarmajus AT shuaihuang diterpenoidalkaloidsfromdelphiniumanthriscifoliumvarmajus AT xianlizhou diterpenoidalkaloidsfromdelphiniumanthriscifoliumvarmajus
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Diterpenoid Alkaloids from Delphinium anthriscifolium var. majus

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