Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease

Abstract Background: Zataria multiflora Boiss is a well-known medicinal plant and its’ essential oil (EO) is traditionally used for treatment of respiratory and digestive disorders and/or bacterial, viral, fungal, and parasitic infections. Objective: This study was undertaken to evaluate the effect...

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Autores principales:	Arash Jafari, Mohammad Moazeni, Seyed Vahid Hosseini, Hajar Khazraei, Samane Nematolahi, Seyed Mohammad Kazem Tadayon
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2020
Materias:	zataria multiflora essential oil hematological parameters biochemical parameters clinical study Medicine R
Acceso en línea:	https://doaj.org/article/ca8e62a9c7e342c3a8ef3f38c623b4cb
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spelling	oai:doaj.org-article:ca8e62a9c7e342c3a8ef3f38c623b4cb2021-11-14T08:12:06ZAlteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease2783-243010.30476/acrr.2020.46473https://doaj.org/article/ca8e62a9c7e342c3a8ef3f38c623b4cb2020-03-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_46473_6fedafc1d0ba4decb42d9375ed7f2a37.pdfhttps://doaj.org/toc/2783-2430Abstract Background: Zataria multiflora Boiss is a well-known medicinal plant and its’ essential oil (EO) is traditionally used for treatment of respiratory and digestive disorders and/or bacterial, viral, fungal, and parasitic infections. Objective: This study was undertaken to evaluate the effect of long-term consumption of Z. multiflora EO on hematological and biochemical parameters in patients infected with liver hydatid disease. Materials and Methods: Fifteen patients were administered orally with Z. multiflora EO (60 mg daily) for six months. Hematological and biochemical analysis were performed on the blood samples of patients before the start of treatment and after completion of the treatment course. In hematological analysis, WBC, RBC, Hb, hematocrit, MCV, MCH, MCHC and platelets were measured. In biochemical analysis, FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, K, Cl, AST, ALT, and ALK were assessed. Results: No apparent changes were observed in the values of hematological parameters of the patients after treatment. No significant changes also occurred in the values of FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, and K. The mean values of AST, ALT and ALK enzymes decreased significantly after treatment (P ˂ 0.05). No adverse clinical event was noticed in the patients during the course of study. Conclusions: Long-term consumption of Z. multiflora EO induced no adverse effect on the hematological and biochemical parameters of patients infected with liver hydatid disease. Since Z. multiflora EO reduced the level of liver transaminases (AST, ALT and ALK), this herbal product may be considered as a hepatoprotective agent in human beings.Arash JafariMohammad MoazeniSeyed Vahid HosseiniHajar KhazraeiSamane NematolahiSeyed Mohammad Kazem TadayonShiraz University of Medical Sciencesarticlezataria multifloraessential oilhematological parametersbiochemical parametersclinical studyMedicineRENIranian Journal of Colorectal Research, Vol 8, Iss 1, Pp 17-22 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	zataria multiflora essential oil hematological parameters biochemical parameters clinical study Medicine R
spellingShingle	zataria multiflora essential oil hematological parameters biochemical parameters clinical study Medicine R Arash Jafari Mohammad Moazeni Seyed Vahid Hosseini Hajar Khazraei Samane Nematolahi Seyed Mohammad Kazem Tadayon Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease
description	Abstract Background: Zataria multiflora Boiss is a well-known medicinal plant and its’ essential oil (EO) is traditionally used for treatment of respiratory and digestive disorders and/or bacterial, viral, fungal, and parasitic infections. Objective: This study was undertaken to evaluate the effect of long-term consumption of Z. multiflora EO on hematological and biochemical parameters in patients infected with liver hydatid disease. Materials and Methods: Fifteen patients were administered orally with Z. multiflora EO (60 mg daily) for six months. Hematological and biochemical analysis were performed on the blood samples of patients before the start of treatment and after completion of the treatment course. In hematological analysis, WBC, RBC, Hb, hematocrit, MCV, MCH, MCHC and platelets were measured. In biochemical analysis, FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, K, Cl, AST, ALT, and ALK were assessed. Results: No apparent changes were observed in the values of hematological parameters of the patients after treatment. No significant changes also occurred in the values of FBS, BUN, creatinine, cholesterol, triglycerides, HDL, LDL, Na, and K. The mean values of AST, ALT and ALK enzymes decreased significantly after treatment (P ˂ 0.05). No adverse clinical event was noticed in the patients during the course of study. Conclusions: Long-term consumption of Z. multiflora EO induced no adverse effect on the hematological and biochemical parameters of patients infected with liver hydatid disease. Since Z. multiflora EO reduced the level of liver transaminases (AST, ALT and ALK), this herbal product may be considered as a hepatoprotective agent in human beings.
format	article
author	Arash Jafari Mohammad Moazeni Seyed Vahid Hosseini Hajar Khazraei Samane Nematolahi Seyed Mohammad Kazem Tadayon
author_facet	Arash Jafari Mohammad Moazeni Seyed Vahid Hosseini Hajar Khazraei Samane Nematolahi Seyed Mohammad Kazem Tadayon
author_sort	Arash Jafari
title	Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease
title_short	Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease
title_full	Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease
title_fullStr	Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease
title_full_unstemmed	Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease
title_sort	alteration in hematological and biochemical parameters following the long-term consumption of zataria multiflora essential oil in patients infected with liver hydatid disease
publisher	Shiraz University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/ca8e62a9c7e342c3a8ef3f38c623b4cb
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Alteration in hematological and biochemical parameters following the long-term consumption of Zataria multiflora essential oil in patients infected with liver hydatid disease

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