Neurocognitive domains and neuropathological changes in experimental infection with Trypanosoma brucei brucei in Wistar rats

Trypanosoma brucei brucei causes animal trypanosomiasis in several vertebrates and human African trypanosomiasis. Previous studies have only explored the incidence, clinical symptoms, haematology and biochemical changes associated with the disease. The behavioral manipulation hypothesis posits that...

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Autores principales:	Olamide Elizabeth Adebiyi, Temidayo Olutayo Omobowale, Mathew Oluwole Abatan
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Trypanosoma brucei Behavior Protozoa Rat Purkinje cells Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/ca90b5d85b8e4206a478f7c5386c0dad
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spelling	oai:doaj.org-article:ca90b5d85b8e4206a478f7c5386c0dad2021-12-02T05:02:19ZNeurocognitive domains and neuropathological changes in experimental infection with Trypanosoma brucei brucei in Wistar rats2405-844010.1016/j.heliyon.2021.e08260https://doaj.org/article/ca90b5d85b8e4206a478f7c5386c0dad2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S240584402102363Xhttps://doaj.org/toc/2405-8440Trypanosoma brucei brucei causes animal trypanosomiasis in several vertebrates and human African trypanosomiasis. Previous studies have only explored the incidence, clinical symptoms, haematology and biochemical changes associated with the disease. The behavioral manipulation hypothesis posits that parasites alter the behavior of host to increase the reproductive abilities of such parasites. Hence, the present study was carried out to investigate changes in behavior and cognition following experimental infection of T. brucei brucei in rat model.This study involved two groups of animals (uninfected control and T. brucei infected) with 8 rats per group. After confirmation of parasitaemia in the infected rats both groups were assessed to investigate if infection led to behavioral alterations and neuropathological changes using the open field, social interaction and forelimb suspension tests. Immunohistochemistry was performed on brain tissues using glial fibrillary acidic protein and anticalbindin-D28k, antibodies.We demonstrated that T. brucei infection triggered a significant decrease in exploratory activity, anxiety-like behavior, altered recognition of social novelty and reduced hanging latency in the hanging wire test. Immunohistochemistry revealed significant astrocytosis, loss of dendritic spines and reduction of Purkinje cell layer of the cerebellum.These results demonstrate that T. brucei infection induce signs of anxiety, impaired motor co-ordination with degeneration and loss of Purkinje cells.Olamide Elizabeth AdebiyiTemidayo Olutayo OmobowaleMathew Oluwole AbatanElsevierarticleTrypanosoma bruceiBehaviorProtozoaRatPurkinje cellsScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08260- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Trypanosoma brucei Behavior Protozoa Rat Purkinje cells Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Trypanosoma brucei Behavior Protozoa Rat Purkinje cells Science (General) Q1-390 Social sciences (General) H1-99 Olamide Elizabeth Adebiyi Temidayo Olutayo Omobowale Mathew Oluwole Abatan Neurocognitive domains and neuropathological changes in experimental infection with Trypanosoma brucei brucei in Wistar rats
description	Trypanosoma brucei brucei causes animal trypanosomiasis in several vertebrates and human African trypanosomiasis. Previous studies have only explored the incidence, clinical symptoms, haematology and biochemical changes associated with the disease. The behavioral manipulation hypothesis posits that parasites alter the behavior of host to increase the reproductive abilities of such parasites. Hence, the present study was carried out to investigate changes in behavior and cognition following experimental infection of T. brucei brucei in rat model.This study involved two groups of animals (uninfected control and T. brucei infected) with 8 rats per group. After confirmation of parasitaemia in the infected rats both groups were assessed to investigate if infection led to behavioral alterations and neuropathological changes using the open field, social interaction and forelimb suspension tests. Immunohistochemistry was performed on brain tissues using glial fibrillary acidic protein and anticalbindin-D28k, antibodies.We demonstrated that T. brucei infection triggered a significant decrease in exploratory activity, anxiety-like behavior, altered recognition of social novelty and reduced hanging latency in the hanging wire test. Immunohistochemistry revealed significant astrocytosis, loss of dendritic spines and reduction of Purkinje cell layer of the cerebellum.These results demonstrate that T. brucei infection induce signs of anxiety, impaired motor co-ordination with degeneration and loss of Purkinje cells.
format	article
author	Olamide Elizabeth Adebiyi Temidayo Olutayo Omobowale Mathew Oluwole Abatan
author_facet	Olamide Elizabeth Adebiyi Temidayo Olutayo Omobowale Mathew Oluwole Abatan
author_sort	Olamide Elizabeth Adebiyi
title	Neurocognitive domains and neuropathological changes in experimental infection with Trypanosoma brucei brucei in Wistar rats
title_short	Neurocognitive domains and neuropathological changes in experimental infection with Trypanosoma brucei brucei in Wistar rats
title_full	Neurocognitive domains and neuropathological changes in experimental infection with Trypanosoma brucei brucei in Wistar rats
title_fullStr	Neurocognitive domains and neuropathological changes in experimental infection with Trypanosoma brucei brucei in Wistar rats
title_full_unstemmed	Neurocognitive domains and neuropathological changes in experimental infection with Trypanosoma brucei brucei in Wistar rats
title_sort	neurocognitive domains and neuropathological changes in experimental infection with trypanosoma brucei brucei in wistar rats
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ca90b5d85b8e4206a478f7c5386c0dad
work_keys_str_mv	AT olamideelizabethadebiyi neurocognitivedomainsandneuropathologicalchangesinexperimentalinfectionwithtrypanosomabruceibruceiinwistarrats AT temidayoolutayoomobowale neurocognitivedomainsandneuropathologicalchangesinexperimentalinfectionwithtrypanosomabruceibruceiinwistarrats AT mathewoluwoleabatan neurocognitivedomainsandneuropathologicalchangesinexperimentalinfectionwithtrypanosomabruceibruceiinwistarrats
_version_	1718400795564572672

Neurocognitive domains and neuropathological changes in experimental infection with Trypanosoma brucei brucei in Wistar rats

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