The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse

Abstract The risk of relapsing into depression after stopping antidepressants is high, but no established predictors exist. Resting-state functional magnetic resonance imaging (rsfMRI) measures may help predict relapse and identify the mechanisms by which relapses occur. rsfMRI data were acquired fr...

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Autores principales:	Isabel M. Berwian, Julia G. Wenzel, Leonie Kuehn, Inga Schnuerer, Lars Kasper, Ilya M. Veer, Erich Seifritz, Klaas E. Stephan, Henrik Walter, Quentin J. M. Huys
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca941e685b1f456ba5afe95111594b48
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spelling	oai:doaj.org-article:ca941e685b1f456ba5afe95111594b482021-12-02T13:33:59ZThe relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse10.1038/s41598-020-79170-92045-2322https://doaj.org/article/ca941e685b1f456ba5afe95111594b482020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79170-9https://doaj.org/toc/2045-2322Abstract The risk of relapsing into depression after stopping antidepressants is high, but no established predictors exist. Resting-state functional magnetic resonance imaging (rsfMRI) measures may help predict relapse and identify the mechanisms by which relapses occur. rsfMRI data were acquired from healthy controls and from patients with remitted major depressive disorder on antidepressants. Patients were assessed a second time either before or after discontinuation of the antidepressant, and followed up for six months to assess relapse. A seed-based functional connectivity analysis was conducted focusing on the left subgenual anterior cingulate cortex and left posterior cingulate cortex. Seeds in the amygdala and dorsolateral prefrontal cortex were explored. 44 healthy controls (age: 33.8 (10.5), 73% female) and 84 patients (age: 34.23 (10.8), 80% female) were included in the analysis. 29 patients went on to relapse and 38 remained well. The seed-based analysis showed that discontinuation resulted in an increased functional connectivity between the right dorsolateral prefrontal cortex and the parietal cortex in non-relapsers. In an exploratory analysis, this functional connectivity predicted relapse risk with a balanced accuracy of 0.86. Further seed-based analyses, however, failed to reveal differences in functional connectivity between patients and controls, between relapsers and non-relapsers before discontinuation and changes due to discontinuation independent of relapse. In conclusion, changes in the connectivity between the dorsolateral prefrontal cortex and the posterior default mode network were associated with and predictive of relapse after open-label antidepressant discontinuation. This finding requires replication in a larger dataset.Isabel M. BerwianJulia G. WenzelLeonie KuehnInga SchnuererLars KasperIlya M. VeerErich SeifritzKlaas E. StephanHenrik WalterQuentin J. M. HuysNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Isabel M. Berwian Julia G. Wenzel Leonie Kuehn Inga Schnuerer Lars Kasper Ilya M. Veer Erich Seifritz Klaas E. Stephan Henrik Walter Quentin J. M. Huys The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse
description	Abstract The risk of relapsing into depression after stopping antidepressants is high, but no established predictors exist. Resting-state functional magnetic resonance imaging (rsfMRI) measures may help predict relapse and identify the mechanisms by which relapses occur. rsfMRI data were acquired from healthy controls and from patients with remitted major depressive disorder on antidepressants. Patients were assessed a second time either before or after discontinuation of the antidepressant, and followed up for six months to assess relapse. A seed-based functional connectivity analysis was conducted focusing on the left subgenual anterior cingulate cortex and left posterior cingulate cortex. Seeds in the amygdala and dorsolateral prefrontal cortex were explored. 44 healthy controls (age: 33.8 (10.5), 73% female) and 84 patients (age: 34.23 (10.8), 80% female) were included in the analysis. 29 patients went on to relapse and 38 remained well. The seed-based analysis showed that discontinuation resulted in an increased functional connectivity between the right dorsolateral prefrontal cortex and the parietal cortex in non-relapsers. In an exploratory analysis, this functional connectivity predicted relapse risk with a balanced accuracy of 0.86. Further seed-based analyses, however, failed to reveal differences in functional connectivity between patients and controls, between relapsers and non-relapsers before discontinuation and changes due to discontinuation independent of relapse. In conclusion, changes in the connectivity between the dorsolateral prefrontal cortex and the posterior default mode network were associated with and predictive of relapse after open-label antidepressant discontinuation. This finding requires replication in a larger dataset.
format	article
author	Isabel M. Berwian Julia G. Wenzel Leonie Kuehn Inga Schnuerer Lars Kasper Ilya M. Veer Erich Seifritz Klaas E. Stephan Henrik Walter Quentin J. M. Huys
author_facet	Isabel M. Berwian Julia G. Wenzel Leonie Kuehn Inga Schnuerer Lars Kasper Ilya M. Veer Erich Seifritz Klaas E. Stephan Henrik Walter Quentin J. M. Huys
author_sort	Isabel M. Berwian
title	The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse
title_short	The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse
title_full	The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse
title_fullStr	The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse
title_full_unstemmed	The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse
title_sort	relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ca941e685b1f456ba5afe95111594b48
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The relationship between resting-state functional connectivity, antidepressant discontinuation and depression relapse

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