In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium implants

Yicheng Cheng,1–3,* Bo Gao,1,3,* Xianghui Liu,2,* Xianghui Zhao,4 Weige Sun,2 Huifang Ren,1,3 Jiang Wu1,3 1Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an, 2Department of Stomatology, Ba...

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Autores principales:	Cheng Y, Gao B, Liu X, Zhao X, Sun W, Ren H, Wu J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Antibacterial coating Halogenated furanone Microarc-oxidized Nanoparticles In vivo Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ca963113fb8f4771ae4d74dfda005f90
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spelling	oai:doaj.org-article:ca963113fb8f4771ae4d74dfda005f902021-12-02T05:10:46ZIn vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium implants1178-2013https://doaj.org/article/ca963113fb8f4771ae4d74dfda005f902016-03-01T00:00:00Zhttps://www.dovepress.com/in-vivo-evaluation-of-an-antibacterial-coating-containing-halogenated--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yicheng Cheng,1–3,* Bo Gao,1,3,* Xianghui Liu,2,* Xianghui Zhao,4 Weige Sun,2 Huifang Ren,1,3 Jiang Wu1,3 1Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an, 2Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing, 3Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an, 4Institute of Neuroscience, School of Basical Medical Science, Fourth Military Medical University, Xi’an, People’s Republic of China *These authors contributed equally to this work Abstract: To prevent peri-implant infection, a new antibacterial coating containing a halogenated furanone compound, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone-loaded poly(l-lactic acid) nanoparticles, has been fabricated. The current study was designed to evaluate the preventive effect of the antibacterial coating under a simulated environment of peri-implant infection in vivo. Microarc-oxidized titanium implants treated with minocycline hydrochloride ointment were used as positive control group, and microarc-oxidized titanium implants without any treatment were used as blank control group. Three kinds of implants were implanted in dogs’ mandibles, and the peri-implant infection was simulated by silk ligation and feeding high sugar diet. After 2-month implantation, the results showed that no significant differences were detected between the experimental and positive control groups (P>0.05), but the data of clinical measurements of the blank control group were significantly higher than those of the other two groups (P<0.05), and the bone–implant contact rate and ultimate interfacial strength were significantly lower than those of the other two groups (P<0.05). Scanning electron microscope observation and histological examination showed that more new bone was formed on the surface of the experimental and positive control groups. It can be concluded that the antibacterial coating fabricated on implants has remarkable preventive effect on peri-implant infection at the early stage. Keywords: antibacterial coating, halogenated furanone, microarc-oxidized, nanoparticles, in vivoCheng YGao BLiu XZhao XSun WRen HWu JDove Medical PressarticleAntibacterial coatingHalogenated furanoneMicroarc-oxidizedNanoparticlesIn vivoMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1337-1347 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antibacterial coating Halogenated furanone Microarc-oxidized Nanoparticles In vivo Medicine (General) R5-920
spellingShingle	Antibacterial coating Halogenated furanone Microarc-oxidized Nanoparticles In vivo Medicine (General) R5-920 Cheng Y Gao B Liu X Zhao X Sun W Ren H Wu J In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium implants
description	Yicheng Cheng,1–3,* Bo Gao,1,3,* Xianghui Liu,2,* Xianghui Zhao,4 Weige Sun,2 Huifang Ren,1,3 Jiang Wu1,3 1Department of Prosthodontics, State Key Laboratory of Military Stomatology, School of Stomatology, Fourth Military Medical University, Xi’an, 2Department of Stomatology, Bayi Hospital, Nanjing University of Chinese Medicine, Nanjing, 3Department of Prosthodontics, Shaanxi Key Laboratory of Stomatology, Xi’an, 4Institute of Neuroscience, School of Basical Medical Science, Fourth Military Medical University, Xi’an, People’s Republic of China *These authors contributed equally to this work Abstract: To prevent peri-implant infection, a new antibacterial coating containing a halogenated furanone compound, (Z-)-4-bromo-5-(bromomethylene)-2(5H)-furanone-loaded poly(l-lactic acid) nanoparticles, has been fabricated. The current study was designed to evaluate the preventive effect of the antibacterial coating under a simulated environment of peri-implant infection in vivo. Microarc-oxidized titanium implants treated with minocycline hydrochloride ointment were used as positive control group, and microarc-oxidized titanium implants without any treatment were used as blank control group. Three kinds of implants were implanted in dogs’ mandibles, and the peri-implant infection was simulated by silk ligation and feeding high sugar diet. After 2-month implantation, the results showed that no significant differences were detected between the experimental and positive control groups (P>0.05), but the data of clinical measurements of the blank control group were significantly higher than those of the other two groups (P<0.05), and the bone–implant contact rate and ultimate interfacial strength were significantly lower than those of the other two groups (P<0.05). Scanning electron microscope observation and histological examination showed that more new bone was formed on the surface of the experimental and positive control groups. It can be concluded that the antibacterial coating fabricated on implants has remarkable preventive effect on peri-implant infection at the early stage. Keywords: antibacterial coating, halogenated furanone, microarc-oxidized, nanoparticles, in vivo
format	article
author	Cheng Y Gao B Liu X Zhao X Sun W Ren H Wu J
author_facet	Cheng Y Gao B Liu X Zhao X Sun W Ren H Wu J
author_sort	Cheng Y
title	In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium implants
title_short	In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium implants
title_full	In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium implants
title_fullStr	In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium implants
title_full_unstemmed	In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium implants
title_sort	in vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(l-lactic acid) nanoparticles on microarc-oxidized titanium implants
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/ca963113fb8f4771ae4d74dfda005f90
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In vivo evaluation of an antibacterial coating containing halogenated furanone compound-loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium implants

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