Predicting Post-operative Blood Inflammatory Biomarkers Using Pre-operative Heart Rate Variability in Patients With Cervical Cancer
Blood inflammatory biomarkers, including the neutrophil-to-lymphocyte ratio (NLR), the lymphocyte-to-monocyte ratio (LMR), and the platelet-to-lymphocyte ratio (PLR), play a significant role in determining the prognosis of patients with cervical cancer (CC). Currently, no methods are available to pr...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:ca9661d2365748d383c8645e28d1b2082021-11-04T06:09:20ZPredicting Post-operative Blood Inflammatory Biomarkers Using Pre-operative Heart Rate Variability in Patients With Cervical Cancer1664-042X10.3389/fphys.2021.696208https://doaj.org/article/ca9661d2365748d383c8645e28d1b2082021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.696208/fullhttps://doaj.org/toc/1664-042XBlood inflammatory biomarkers, including the neutrophil-to-lymphocyte ratio (NLR), the lymphocyte-to-monocyte ratio (LMR), and the platelet-to-lymphocyte ratio (PLR), play a significant role in determining the prognosis of patients with cervical cancer (CC). Currently, no methods are available to predict these indexes pre-operatively. Cardiac autonomic function is determined based on the heart rate variability (HRV), which is also associated with a progressive inflammatory response and cancer. Thus, the main aim of this study was to evaluate the feasibility of using pre-operative HRV parameters in CC patients to predict post-operative blood inflammation biomarkers as a means of determining prognosis. Between 2020 and 2021, 56 patients who were diagnosed with CC and then underwent hysterectomy surgery at the Department of Gynecologic Oncology, First Affiliated Hospital, Bengbu Medical College were enrolled in this study. Five-minute electrocardiogram data were collected 1 day before the operation for analysis of HRV parameters, including frequency domain parameters (LF, HF, and LF/HF) and Poincaré plot parameters (SD1, SD2, and SD2/SD1). Venous blood was collected 2 days post-operatively and inflammatory biomarkers were evaluated, with the NLR, LMR, and PLR determined. Pre-operative SD2 was significantly associated with post-operative PLR, with each 1-unit increase in SD2 decreasing the PLR value by 2.4 ± 0.9 (P < 0.05). Besides, LF/HF was significantly correlated with NLR, with each 1-unit increase in LF/HF increasing the NLR value by 1.1 ± 0.5 (P < 0.05). This association was independent of patient age and body mass index. These results suggest that the pre-operative autonomic nervous system plays a role in the regulation of post-operative cancer inflammation and that pre-operative HRV parameters can potentially predict post-operative inflammation and facilitate clinical treatment decisions.Jian LiuShiqi LiuShiqi LiuLongfei GaoGuangqiao LiGuangqiao LiJie XuYilin SunJingfeng WangJingfeng WangBo ShiBo ShiFrontiers Media S.A.articlecervical cancerheart rate variabilityautonomic nervousinflammatory biomarkersPoincaré plotfrequency domainPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021) |
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DOAJ |
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EN |
| topic |
cervical cancer heart rate variability autonomic nervous inflammatory biomarkers Poincaré plot frequency domain Physiology QP1-981 |
| spellingShingle |
cervical cancer heart rate variability autonomic nervous inflammatory biomarkers Poincaré plot frequency domain Physiology QP1-981 Jian Liu Shiqi Liu Shiqi Liu Longfei Gao Guangqiao Li Guangqiao Li Jie Xu Yilin Sun Jingfeng Wang Jingfeng Wang Bo Shi Bo Shi Predicting Post-operative Blood Inflammatory Biomarkers Using Pre-operative Heart Rate Variability in Patients With Cervical Cancer |
| description |
Blood inflammatory biomarkers, including the neutrophil-to-lymphocyte ratio (NLR), the lymphocyte-to-monocyte ratio (LMR), and the platelet-to-lymphocyte ratio (PLR), play a significant role in determining the prognosis of patients with cervical cancer (CC). Currently, no methods are available to predict these indexes pre-operatively. Cardiac autonomic function is determined based on the heart rate variability (HRV), which is also associated with a progressive inflammatory response and cancer. Thus, the main aim of this study was to evaluate the feasibility of using pre-operative HRV parameters in CC patients to predict post-operative blood inflammation biomarkers as a means of determining prognosis. Between 2020 and 2021, 56 patients who were diagnosed with CC and then underwent hysterectomy surgery at the Department of Gynecologic Oncology, First Affiliated Hospital, Bengbu Medical College were enrolled in this study. Five-minute electrocardiogram data were collected 1 day before the operation for analysis of HRV parameters, including frequency domain parameters (LF, HF, and LF/HF) and Poincaré plot parameters (SD1, SD2, and SD2/SD1). Venous blood was collected 2 days post-operatively and inflammatory biomarkers were evaluated, with the NLR, LMR, and PLR determined. Pre-operative SD2 was significantly associated with post-operative PLR, with each 1-unit increase in SD2 decreasing the PLR value by 2.4 ± 0.9 (P < 0.05). Besides, LF/HF was significantly correlated with NLR, with each 1-unit increase in LF/HF increasing the NLR value by 1.1 ± 0.5 (P < 0.05). This association was independent of patient age and body mass index. These results suggest that the pre-operative autonomic nervous system plays a role in the regulation of post-operative cancer inflammation and that pre-operative HRV parameters can potentially predict post-operative inflammation and facilitate clinical treatment decisions. |
| format |
article |
| author |
Jian Liu Shiqi Liu Shiqi Liu Longfei Gao Guangqiao Li Guangqiao Li Jie Xu Yilin Sun Jingfeng Wang Jingfeng Wang Bo Shi Bo Shi |
| author_facet |
Jian Liu Shiqi Liu Shiqi Liu Longfei Gao Guangqiao Li Guangqiao Li Jie Xu Yilin Sun Jingfeng Wang Jingfeng Wang Bo Shi Bo Shi |
| author_sort |
Jian Liu |
| title |
Predicting Post-operative Blood Inflammatory Biomarkers Using Pre-operative Heart Rate Variability in Patients With Cervical Cancer |
| title_short |
Predicting Post-operative Blood Inflammatory Biomarkers Using Pre-operative Heart Rate Variability in Patients With Cervical Cancer |
| title_full |
Predicting Post-operative Blood Inflammatory Biomarkers Using Pre-operative Heart Rate Variability in Patients With Cervical Cancer |
| title_fullStr |
Predicting Post-operative Blood Inflammatory Biomarkers Using Pre-operative Heart Rate Variability in Patients With Cervical Cancer |
| title_full_unstemmed |
Predicting Post-operative Blood Inflammatory Biomarkers Using Pre-operative Heart Rate Variability in Patients With Cervical Cancer |
| title_sort |
predicting post-operative blood inflammatory biomarkers using pre-operative heart rate variability in patients with cervical cancer |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/ca9661d2365748d383c8645e28d1b208 |
| work_keys_str_mv |
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