The amyloid precursor protein (APP) does not have a ferroxidase site in its E2 domain.

The amyloid precursor protein (APP) does not have a ferroxidase site in its E2 domain.

The ubiquitous 24-meric iron-storage protein ferritin and multicopper oxidases such as ceruloplasmin or hephaestin catalyze oxidation of Fe(II) to Fe(III), using molecular oxygen as oxidant. The ferroxidase activity of these proteins is essential for cellular iron homeostasis. It has been reported t...

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Autores principales: Kourosh Honarmand Ebrahimi, Christian Dienemann, Sandra Hoefgen, Manuel E Than, Peter-Leon Hagedoorn, Wilfred R Hagen
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/ca9b0d642a954b27964934071661ea99
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