Android fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly people.

<h4>Background</h4>Fat accumulation in android compartments may confer increased metabolic risk. The incremental utility of measuring regional fat deposition in association with metabolic syndrome (MS) has not been well described particularly in an elderly population.<h4>Methods an...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Seon Mee Kang, Ji Won Yoon, Hwa Young Ahn, So Yeon Kim, Kyoung Ho Lee, Hayley Shin, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Soo Lim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ca9bd09792b54dabb722617c92961262
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ca9bd09792b54dabb722617c92961262
record_format	dspace
spelling	oai:doaj.org-article:ca9bd09792b54dabb722617c929612622021-11-18T07:34:26ZAndroid fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly people.1932-620310.1371/journal.pone.0027694https://doaj.org/article/ca9bd09792b54dabb722617c929612622011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22096613/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Fat accumulation in android compartments may confer increased metabolic risk. The incremental utility of measuring regional fat deposition in association with metabolic syndrome (MS) has not been well described particularly in an elderly population.<h4>Methods and findings</h4>As part of the Korean Longitudinal Study on Health and Aging, which is a community-based cohort study of people aged more than 65 years, subjects (287 male, 75.9±8.6 years and 278 female, 76.0±8.8 years) with regional body composition data using Dual energy X-ray absorptiometry for android/gynoid area, computed tomography for visceral/subcutaneous adipose tissue (VAT/SAT), and cardiometabolic markers including adiponectin and high-sensitivity CRP were enrolled. We investigated the relationship between regional body composition and MS in multivariate regression models. Mean VAT and SAT area was 131.4±65.5 cm(2) and 126.9±55.2 cm(2) in men (P = 0.045) and 120.0±46.7 cm(2) and 211.8±65.9 cm(2) in women (P<0.01). Mean android and gynoid fat amount was 1.8±0.8 kg and 2.5±0.8 kg in men and 2.0±0.6 kg and 3.3±0.8 kg in women, respectively (both P<0.01). VAT area and android fat amount was strongly correlated with most metabolic risk factors compared to SAT or gynoid fat. Furthermore, android fat amount was significantly associated with clustering of MS components after adjustment for multiple parameters including age, gender, adiponectin, hsCRP, a surrogate marker of insulin resistance, whole body fat mass and VAT area.<h4>Conclusions</h4>Our findings are consistent with the hypothesized role of android fat as a pathogenic fat depot in the MS. Measurement of android fat may provide a more complete understanding of metabolic risk associated with variations in fat distribution.Seon Mee KangJi Won YoonHwa Young AhnSo Yeon KimKyoung Ho LeeHayley ShinSung Hee ChoiKyong Soo ParkHak Chul JangSoo LimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27694 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seon Mee Kang Ji Won Yoon Hwa Young Ahn So Yeon Kim Kyoung Ho Lee Hayley Shin Sung Hee Choi Kyong Soo Park Hak Chul Jang Soo Lim Android fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly people.
description	<h4>Background</h4>Fat accumulation in android compartments may confer increased metabolic risk. The incremental utility of measuring regional fat deposition in association with metabolic syndrome (MS) has not been well described particularly in an elderly population.<h4>Methods and findings</h4>As part of the Korean Longitudinal Study on Health and Aging, which is a community-based cohort study of people aged more than 65 years, subjects (287 male, 75.9±8.6 years and 278 female, 76.0±8.8 years) with regional body composition data using Dual energy X-ray absorptiometry for android/gynoid area, computed tomography for visceral/subcutaneous adipose tissue (VAT/SAT), and cardiometabolic markers including adiponectin and high-sensitivity CRP were enrolled. We investigated the relationship between regional body composition and MS in multivariate regression models. Mean VAT and SAT area was 131.4±65.5 cm(2) and 126.9±55.2 cm(2) in men (P = 0.045) and 120.0±46.7 cm(2) and 211.8±65.9 cm(2) in women (P<0.01). Mean android and gynoid fat amount was 1.8±0.8 kg and 2.5±0.8 kg in men and 2.0±0.6 kg and 3.3±0.8 kg in women, respectively (both P<0.01). VAT area and android fat amount was strongly correlated with most metabolic risk factors compared to SAT or gynoid fat. Furthermore, android fat amount was significantly associated with clustering of MS components after adjustment for multiple parameters including age, gender, adiponectin, hsCRP, a surrogate marker of insulin resistance, whole body fat mass and VAT area.<h4>Conclusions</h4>Our findings are consistent with the hypothesized role of android fat as a pathogenic fat depot in the MS. Measurement of android fat may provide a more complete understanding of metabolic risk associated with variations in fat distribution.
format	article
author	Seon Mee Kang Ji Won Yoon Hwa Young Ahn So Yeon Kim Kyoung Ho Lee Hayley Shin Sung Hee Choi Kyong Soo Park Hak Chul Jang Soo Lim
author_facet	Seon Mee Kang Ji Won Yoon Hwa Young Ahn So Yeon Kim Kyoung Ho Lee Hayley Shin Sung Hee Choi Kyong Soo Park Hak Chul Jang Soo Lim
author_sort	Seon Mee Kang
title	Android fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly people.
title_short	Android fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly people.
title_full	Android fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly people.
title_fullStr	Android fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly people.
title_full_unstemmed	Android fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly people.
title_sort	android fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly people.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/ca9bd09792b54dabb722617c92961262
work_keys_str_mv	AT seonmeekang androidfatdepotismorecloselyassociatedwithmetabolicsyndromethanabdominalvisceralfatinelderlypeople AT jiwonyoon androidfatdepotismorecloselyassociatedwithmetabolicsyndromethanabdominalvisceralfatinelderlypeople AT hwayoungahn androidfatdepotismorecloselyassociatedwithmetabolicsyndromethanabdominalvisceralfatinelderlypeople AT soyeonkim androidfatdepotismorecloselyassociatedwithmetabolicsyndromethanabdominalvisceralfatinelderlypeople AT kyoungholee androidfatdepotismorecloselyassociatedwithmetabolicsyndromethanabdominalvisceralfatinelderlypeople AT hayleyshin androidfatdepotismorecloselyassociatedwithmetabolicsyndromethanabdominalvisceralfatinelderlypeople AT sungheechoi androidfatdepotismorecloselyassociatedwithmetabolicsyndromethanabdominalvisceralfatinelderlypeople AT kyongsoopark androidfatdepotismorecloselyassociatedwithmetabolicsyndromethanabdominalvisceralfatinelderlypeople AT hakchuljang androidfatdepotismorecloselyassociatedwithmetabolicsyndromethanabdominalvisceralfatinelderlypeople AT soolim androidfatdepotismorecloselyassociatedwithmetabolicsyndromethanabdominalvisceralfatinelderlypeople
_version_	1718423313115512832

Android fat depot is more closely associated with metabolic syndrome than abdominal visceral fat in elderly people.

Ejemplares similares