The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis
Hyperactivation of TGFβ signaling is a common feature of fibrotic diseases. Here the authors show that genetic or pharmacologic inactivation of the tyrosine phosphatase SHP2 prevents TGFβ-induced JAK2/STAT3 signaling, inhibits fibroblast activation and exerts potent anti-fibrotic effects.
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Nature Portfolio
2018
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oai:doaj.org-article:ca9d656a05724b31bfb9bc55df9634bf2021-12-02T14:38:51ZThe tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis10.1038/s41467-018-05768-32041-1723https://doaj.org/article/ca9d656a05724b31bfb9bc55df9634bf2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05768-3https://doaj.org/toc/2041-1723Hyperactivation of TGFβ signaling is a common feature of fibrotic diseases. Here the authors show that genetic or pharmacologic inactivation of the tyrosine phosphatase SHP2 prevents TGFβ-induced JAK2/STAT3 signaling, inhibits fibroblast activation and exerts potent anti-fibrotic effects.Ariella ZehenderJingang HuangAndrea-Hermina GyörfiAlexandru-Emil MateiThuong Trinh-MinhXiaohan XuYi-Nan LiChih-Wei ChenJianping LinClara DeesChristian BeyerKolja GelseZhong-Yin ZhangChristina BergmannAndreas RammingWalter BirchmeierOliver DistlerGeorg SchettJörg H. W. DistlerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ariella Zehender Jingang Huang Andrea-Hermina Györfi Alexandru-Emil Matei Thuong Trinh-Minh Xiaohan Xu Yi-Nan Li Chih-Wei Chen Jianping Lin Clara Dees Christian Beyer Kolja Gelse Zhong-Yin Zhang Christina Bergmann Andreas Ramming Walter Birchmeier Oliver Distler Georg Schett Jörg H. W. Distler The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis |
| description |
Hyperactivation of TGFβ signaling is a common feature of fibrotic diseases. Here the authors show that genetic or pharmacologic inactivation of the tyrosine phosphatase SHP2 prevents TGFβ-induced JAK2/STAT3 signaling, inhibits fibroblast activation and exerts potent anti-fibrotic effects. |
| format |
article |
| author |
Ariella Zehender Jingang Huang Andrea-Hermina Györfi Alexandru-Emil Matei Thuong Trinh-Minh Xiaohan Xu Yi-Nan Li Chih-Wei Chen Jianping Lin Clara Dees Christian Beyer Kolja Gelse Zhong-Yin Zhang Christina Bergmann Andreas Ramming Walter Birchmeier Oliver Distler Georg Schett Jörg H. W. Distler |
| author_facet |
Ariella Zehender Jingang Huang Andrea-Hermina Györfi Alexandru-Emil Matei Thuong Trinh-Minh Xiaohan Xu Yi-Nan Li Chih-Wei Chen Jianping Lin Clara Dees Christian Beyer Kolja Gelse Zhong-Yin Zhang Christina Bergmann Andreas Ramming Walter Birchmeier Oliver Distler Georg Schett Jörg H. W. Distler |
| author_sort |
Ariella Zehender |
| title |
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis |
| title_short |
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis |
| title_full |
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis |
| title_fullStr |
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis |
| title_full_unstemmed |
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis |
| title_sort |
tyrosine phosphatase shp2 controls tgfβ-induced stat3 signaling to regulate fibroblast activation and fibrosis |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/ca9d656a05724b31bfb9bc55df9634bf |
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